Pyrophosphate and Metaphosphate as Next-generation Cathode Material for Energy Storage Devices

Students of Indian Institute of Science, Bangalore Ritambhara Gond, Krishnakanth Sada, Anshuman Chaupatnaik won the award for a Pyrophosphate and Metaphosphate as Next-generation Cathode Material for Energy Storage Devices. They carried their project work under the guidance of Prof. Prabeer Barpanda

These days it is very common to see portable electronics everywhere and soon petrol and diesel vehicles need to be replaced by electric vehicles to save our planet earth from global warming. The growing concern is to develop cost-effective, much safer, and long cycled life Li-ion batteries. Large storage devices such as for grid storage we need very efficient Na-ion batteries. The cathode, being a major component in any battery can alone raise the energy density of batteries up to 57% by doubling its capacity. Combining good electrochemical performance to safety and materials economy, chemists have discovered suites of cathode materials where the story started with oxides (e.g. LiCoO2 , LiMn2 O4 , LiMn3/2 Ni1/2 O4 , LiCo1/3, M 1/3, Ni1/3,O2 ), a plethora of polyanionic compounds have followed the suit. Among polyanionic compounds, LiFePO4 has seen the commercialization.

 

 

 

 

 

 

 

 

 

 

These polyanionic class of materials has been proven a ground for material discovery for Li-ion and Na-ion batteries with promising electrochemical performance along with chemical/ thermal stability, economy and operational safety. Lab-scale Na-ion batteries have been made from NaCo (PO3 )3 and NaFe(PO3 )3 but while studying intercalation chemistry, we found them to be a more efficient catalyst for metal-air batteries than the cathode. Another material which was studied and possible commercialization for large scale energy storage for Na-ion batteries can be imagined is pyrophosphate. Sodium metal pyrophosphate (Na2-x T M P2 O7 , T M = Fe, Co) forms an economic cathode alternative with a 3 V operation (vs Na/Na+) having capacity approaching 90 mAh/g with excellent rate kinetics and reversibility. For these polyanionic compounds, the strong inductive effect can increase the energy of the transition-metal redox couple and enhance the operating potential vis-a-vis sodium oxide cathodes.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Ritambhara Gond, Krishnakanth Sada and Anshuman Chaupatnaik, Indian Institute of Science, Bangalore at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Bhu-goal : Predicting Moods of India

Students of Chitkara University, Punjab, Kartik Vij, Rahul Kinra, Rouble Gupta and Debarshi Ghosh won the award for a Bhu-goal : Predicting Moods Of India. They carried their project work under the guidance of Dr. Nitin K. Saluja.

After working with the farmer community from the last few years, our team has seen farmers complaining God for the uncertainty of weather. When we suggest farmers to follow weather predictions available through applications, the exact words from them are “It doesn’t provide us with information about our village” means it is not precise for our village location. The uncertainty about information through weather satellite is quite high. It is difficult to afford such high technology satellites by developing country like India for the next few decades. Hence, the alternate sources should be used for precise information about the weather. The proposed product BhuGoal uses satellite TV signal distortion for precise prediction of rain at a defined location.

BhuGoal predicts the rain exactly 2 hours before it is expected with far more accuracy than the billion-dollar satellite. Satellite TV signals use Ku (nearby 10 GHz) band to communicate the channels. While it is established scientifically that the rain impact TV signals as the cloud formation happens before the rain. While the signal distortion is a function of weather condition, the distortion behaviour depends on the channel we are watching. Hence, a network of BhuGoal node will be established with the help of SRISTI to create multispectral and multiple location data. Hence, the nodes installed in different positions provide additional spatial information regarding the current position of clouds and hence it improves the prediction further.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Kartik Vij, Rahul Kinra, Rouble Gupta and Debarshi Ghosh, Chitkara University, Punjab at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Smart Signalling And Interlocking System

Students of M.Kumarasamy College of Engineering, Tamil Nadu, S. Karthikeyan, S. Umasankar and Karthikeyan S. won the award for a Smart Signalling And Interlocking System. They carried their project work under the guidance of Dr C. Ramesh.

During the foggy condition, the Loco Pilot driver is unable to see the signals, so an innovative approach was done to make a Smart System which uses a Low Power High Range Radio signals to transmit the signal between Station Master, MACL Signal and Loco pilot cabin. This system uses a special data packets for effective communication between the devices. These Data packets carry the information like Train Parameters, Loco pilot Parameters(VCD) etc. The vigilance control system helps in identifying the alertness of loco pilot. The Smart signalling uses the current technology of railways like axle counter and MACL signals for effective usage of Data Produced by them. This results in real-time monitoring of various parameters of rolling stock and MACL signals. The use of axle counters in railyard management software which uses data from various occupancy to switch and prevent the traffic routes. This system does not need Internet connectivity for transmission of data from train to station master cabin. Display panels are provided at both places of station master room and Loco cabin. This shows the real-time details of various parameters. Some of the components used in our system are relays, radio transceiver system. The main aim of our project is to increase the operation of railways in various climatic conditions. The team has designed a system on the objective of “One solution to solve various problems”. As a result of it the smart system also helps in solving the various problems like Unmanned Level Crossing and Manned Level Crossing, Alertness of the Loco Pilot while driving, Real-Time Monitoring of various parameters in operation of a train.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to S. Karthikeyan, S. Umasankar and Karthikeyan S., M.Kumarasamy College of Engineering, Tamil Nadu, at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Fibonacci Series based Rectangular Microstrip Patch Antenna

Students of National Institute of Technology, Goa(NIT), Deven G. Patanvariya and Kalyan Sundar Kola won the award for a Fibonacci Series based Rectangular Microstrip Patch Antenna. They carried their project work under the guidance of Dr Anirban Chatterjee.

The project presents a new fractal microstrip antenna, which is derived from the Fibonacci series and Koch snowflake first iteration. The proposed structure has four-fold centrosymmetric about the origin. The symmetry is obtained by implementing a Fibonacci square box followed by etching of Koch snowflake (first iteration) in all the four quadrants of the structure. The overall dimension of the proposed fractal geometry is interrelated with the area of the smallest square box (C1 ) inside the geometry. Therefore, the resonating frequency of a microstrip antenna, based on the proposed design, can be determined by choosing the length of the smallest square box (in mm) inside the fractal geometry.

Moreover, the proposed geometry provides a balance between the etched and un-etched portion in the radiating surface of the patch and thereby capable of providing satisfactory gain as compared to the most commonly available fractal microstrip patch antennas. The proposed fractal can also be an excellent choice to design antennas for Bluetooth, WiMAX, ISM, C, X, Ku, K -band applications, since it can provide very good gain and bandwidth while operating in the corresponding frequencies. The fabricated prototype can directly be used for DSRC application since it satisfies the gain and bandwidth requirement. Moreover, the design of the proposed antenna using three different substrate material of Roger 5880, Neltec (NX9320) and FR-4, satisfy the gain and bandwidth requirements for the DSRC band.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Deven G. Patanvariya and Kalyan Sundar Kola, National Institute of Technology, Goa(NIT) at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

An Automated Panipuri Vending Machine

Students of Tezpur University, Assam, Abhijit Nath, Saurav Jyoti Sarma and Chandeep S. Gogoi won the award for an Automated Panipuri Vending Machine. They carried their project work under the guidance of Er. Polash Pratim Dutta.

The focus of the PVM is to provide hygienic panipuri and to deliver it without consuming much time with a 24/7 service experience to the customers. This machine will work as a single unit, but it will contain various subunits for storing individual items such as hollow bread, different types of ingredients, various types of flavoured water and sauces too. These individual items can be replenished manually when required. The whole process starts with washing and boiling of the potatoes automatically. Then comes the mashing section where all the ingredients and the potatoes will be mashed for making the required paste that will be injected inside the hollow bread. A small heater is attached inside the system to keep the hollow breads fresh and crispy. Since various types of flavoured water will be stored, a refrigerating unit will be there to keep the flavoured water cool and fresh. All the processes will be controlled by a single control unit. This vending machine also has a processing unit which makes panipuri as per customer’s requirements. An interface unit (OLED screen) is there which allows a customer to choose the appropriate option and guided instruction for a transaction. Opening a new stall takes a lot of space but installing this machine will reduce the space requirement. The machine can be moved from one place to others where the electricity is available. It is very easy to install in places like malls, restaurants, luxury hotels, airports etc. This machine is believed to promote acceptability and ensure availability of this Indian Snack across the world.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Abhijit Nath, Saurav Jyoti Sarma and Chandeep S. Gogoi, Tezpur University, Assam, at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Manufacture of Micronutrient Fortified Rice Kernels through Extrusion Technology

Students of Indian Institute of Technology, Kharagpur, Dalbhagat Chandrakant Genu and Jayshree Majumdar won the award for a Manufacture of Micronutrient Fortified Rice Kernels through Extrusion Technology. They carried their project work under the guidance of Dr. H N Mishra.

Iron deficiency anaemia (IDA) has become a serious problem in India. National Family Health Survey (2015-16) revealed that almost half the population is affected (Children- 58.4%, Women – 53 %; Men-22.7 %) with anaemia. Fortification of staple food with essential micronutrients would be a key solution to alleviate the IDA. Being staple food, rice provides a unique opportunity for the micronutrient fortification which leads to address the prevalence of IDA among the affected population. Fortified rice kernels (FRK) have been developed by using rice broken (a byproduct of rice milling industry) and micronutrient premix (containing iron, folic acid and vitamin B12) in three different sizes (long, medium and small) using extrusion technology.

The FRK contains 280-425 mg of iron, 750-1250 µg of folic acid and 7.5 – 12.5 µg of vitamin B 12 per 100 g according to the Food Safety and Standards (Fortification of Foods) Regulation, 2016. Optimization of the extrusion process parameters such as die head temperature, barrel temperature, screw speed, feeder screw speed and feed moisture content were done to produce FRKs which resemble the natural rice in physical, nutritional, sensory & cooking characteristics. Drying process was standardized to avoid any fissure formation in the FRKs. The FRK, thus produced, is mixed with the natural rice in the ratio of 1:100 to obtain iron-fortified rice (IFR). Sensory study of rice dishes prepared using FRK (made by using Sona masuri Cv. rice) had shown a good resemblance with those of the natural rice dishes both in raw and cooked form. The iron losses during washing (1%), soaking (2%), cooking were negligible (8%). A pilot-scale facility of production capacity 100 kg FRK per day has been established at IIT Kharagpur, promoting the concept of “Make in India”.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Dalbhagat Chandrakant Genu and Jayshree Majumdar, Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Development of Process Technology for Manufacture of RTD Carbonated Grain Beverage

Students of Indian Institute of Technology, Kharagpur, Anjali Thakur and Pooja Pandey won the award for a Development of Process Technology for Manufacture of RTD Carbonated Grain Beverage. They carried their project work under the guidance of Dr. H N Mishra.

There is a huge demand for carbonated soft drinks amongst the consumers. Most of the available soft drinks typically contain artificial sweeteners, colors and harmful additives which lead to set of diseases like diabetes, obesity, teeth & bone damage, decrease in metabolism etc. Therefore, a cereal-based carbonated beverage mixed with adequate protein and energy can serve as a healthy alternative. Maize and Bengal gram were roasted at a temperature of 160-180C while finger millet at 80- 120C for 10-30 min. The optimized conditions for roasting of the maize, Bengal gram and ragi were 180C for 10 min, 180C for 27 min and 110C for 30 min; respectively were determined using face centred composite design (FCCD) and response surface methodology (RSM).

The formulation of the beverage premix was obtained using linear programming in the combination of 30g, 30g, 10g, 20g and 10g of roasted maize, Bengal gram, finger millet flours, sugar (powdered) and pea protein isolate, respectively. The formulated instant carbonated cereal beverage was high in protein and energy at low cost (Rs 10/100 g). The prepared carbonated grain-based drink was very much nutritious (16% protein and 390 Cal/ 100g energy). The final formulation obtained gave an adequate amount of iron (11.6 mg/100 g). The effect of carbonation was found best for 8% carbonation powder concentration with 1:4 beverage mix to water ratio. The sensory evaluation showed overall acceptability of 7.7. Unique features are as follows-

  • The formulated instant carbonated cereal beverage with high protein, energy and low cost in the form of dry powder is one of the unique features of the present beverage mix.
  • The prepared carbonated grain-based drink is very much nutritious (16% protein) and easily digestible. 
  • The final formulation obtained gave an adequate amount of iron (11.6 mg/100 g). 
  • The sensory evaluation showed overall acceptability of 7.7. 
  • The effect of carbonation was found best for 8% carbonation powder concentration with 1:4 beverage mix to water ratio. 
  • Dry beverage powder can be easily stored in sachets or sealed containers with maximum flexibility of transportation.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Anjali Thakur and Pooja Pandey, Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Audience response device for Deaf and mute classroom

Student of Indira Gandhi Delhi Technical University for Women(IGDTUW), Manasi Mishra won the award for a Audience response device for Deaf and mute classroom. They carried their project work under the guidance of Prof. S. RN Reddy.

Speaking and hearing plays an important role in effective teaching, individuals who lack these abilities faces an uphill battle. Quantum of work has focused on designing various approaches to teach deaf and mute students. However, it is equally important to assess whether students are following the course materials or there is a need to adjust the pace and methodology of teaching. Creating an active learning environment in D & M classroom is a tedious task as it becomes very difficult for a teacher to observe every student’s response at a time through sign language. The level of their enthusiasm and active engagements in the classroom can degrade due to being unheard or unnoticed. This scenario demotivates them to respond in classroom. This innovation can facilitate multiple classroom activities easily without the need for speaking or hearing such as performing quiz, aggregating & analyzing student’s responses, taking attendance, receiving student’s feedback & handling queries, assessment of every individual, Assistance for emergency or panic situation.

Real-time feedback will allow the lecturer to adapt the lecture during the presentation so as to achieve the maximum efficiency during the lecture & also to modify the future lectures based on the “lessons learned” from the past cases. Students whose performance is poor needs special attention; their performance can be shared automatically to their guardians via E-mail. In future it can also be integrated with the learning management system designed specially for deaf & mute students. This system is low cost, easy to use & configure, uses the light weight protocol for device to device communication, allows remote monitoring through the use of cloud computing technology, highly scalable, can be easily integrated with existing infrastructure.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Manasi Mishra, Indira Gandhi Delhi Technical University for Women(IGDTUW) at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Multifunctional Granulator (MFG) -A Multi functional device to prepare dried spherical granules

Student of Andhra University College of Pharmaceutical Sciences, Visakhapatnam, Rajendra Prasad Moturu won the award for a Multifunctional Granulator (MFG) -A Multifunctional device to prepare dried spherical granules. They carried their project work under the guidance of Prof. K.V. Ramana Murthy.

From the past drug discovery had made the new exploration in the field of R&D and Production. Even though most of the drugs are discovered, the way of presenting these drugs to the patients has not changed since the tablet dosage form is playing a key role in patient health care management, due to its patient compliance. The manufacturing process of the tablets dosage form is having more number of process steps like mixing, wet massing, granulation, drying, size separation, punching and it is a very tedious process depending upon preparation technique. The present new innovation “Multi-Functional- Granulator” can make a new trend in the production of granulation industries, as it is designed to be single equipment for all these steps. Multi-Functional- Granulator is well-designed equipment involving mixing, wet massing, granulation, drying and size separation of dried spherical granules.

By using this equipment we can see a 3-Dimensional mixing which is required for uniform mixing and wet massing. Granulation technique is also well designed as it is having a double granulation to form spherical granulation of selective size requirement. The next subsequent step in the process is to dry the spherical granules, this is achieved through more surface area in less space by passing hot air through spirally arranged trays. These granules are collected according to their sizes by using a size separation technique-“Sieve Analysis”. All these process steps described are performed within a single equipment therefore it reduces the cost, time, set up area/space, human intervention and it is one of the best equipment in the point of design and efficiency for granulation industries like Pharmaceuticals, API; Chemicals, Ayurvedic, New Chemical Entities (R&D), Fertilizers and Detergents.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Rajendra Prasad Moturu, Andhra University College Of Pharmaceutical Sciences, Visakhapatnam at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

A Simple, Non-invasive, Low Cost, Point of Care, Colorimetric Method, using Reactive Oxygen Species induced Lipid Peroxidative changes in Saliva, to Assess the Risk of Oral Pre-cancerous Lesions and Oral Squamous Cell Carcinoma in Chronic Smokers

Student of Greenwood High International School, Bengaluru, Nikhiya Shamsher won the award for research work of A Simple, Non-invasive, Low Cost, Point of Care, Colorimetric Method, using Reactive Oxygen Species induced Lipid Peroxidative changes in Saliva, to Assess the Risk of Oral Pre-cancerous Lesions and Oral Squamous Cell Carcinoma in Chronic Smokers. They carried their project work under the guidance of Aloysius D’Mello.

Smoking, the leading cause of oral cancer in India, kills over 5 people every hour. As high mortality is due to late diagnosis, early detection is vital. Free radical-induced lipid peroxidation (LP) is known to promote multistep oral carcinogenesis. Free radicals generated by smoking, damage polyunsaturated fatty acids releasing end-product Malondialdehyde (MDA). A simple, home-based test was devised to determine salivary Malondialdehyde to assess the early risk of oral pre-cancer and cancer. It was hypothesized that heavier smokers would exhibit a greater degree of salivary LP.

A highly sensitive QuitPuff reagent was formulated which when heated with saliva, produces a colour change, directly proportional to the amount of MDA. The MDA level was measured by matching the color change with a colorimetric Lipid Peroxidation Index (LPI) chart. QuitPuff was tested on 500 subjects and validated using UV Spectroscopy, the gold standard for the test. The mean LPI was consistently and significantly elevated (P & lt; 0.001) in smokers with oral pre-cancer and cancer (4.34), smokers who smoked more than 20 (4.12), between 10-20 (3.43) and less than 10 cigarettes per day (2.43) as compared to non-smokers (0.26). The mean LPI’s of the test and validation methods correlated. Spearman’s correlation indicated a significant positive association between colour changes and UV spectroscopy readings (r=0.93). QuitPuff detected the salivary MDA levels with 96% accuracy. Smokers exhibited a greater degree of salivary LP as compared to non-smokers, the heavier the smoker, greater was the degree of LP. QuitPuff has great potential as a point-of-care test for oral pre-cancer and cancer.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Nikhiya Shamsher, Greenwood High International School, Bengaluru at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Understanding Sequence-Disorder-Function Relationship of an Intrinsically Disordered Protein to Design Soil Salinity Sensor

Student of Indian Institute of Technology, Madras, Sneha Munshi won the award for research work of Understanding Sequence-Disorder-Function Relationship of an Intrinsically Disordered Protein to Design Soil Salinity Sensor. They carried their project work under the guidance of Dr Athi Narayanan N.

Soil is one of the important elements of our ecosystems which has been subjected to degradation due to both natural and man-made causes. Native rock weathering, low precipitation, high surface evaporation, wind, irrigation with saline water or disposal of solid waste severely affect the salinity of the soil. The statistical analysis revealed loss of 12 billion dollars of the agricultural crop every year and 3,230,000 km2 irrigated land has been affected globally. To handle these issues on time, soil salinity needs to be monitored routinely. Advancements have been made in recent years to explore intrinsically disordered proteins (IDPs) as biosensors. These are an essential part of proteome and do not possess any well-defined structure but still are functional.

These proteins are highly sensitive to temperature and solvent fluctuations. In current work, we have revealed the effect of increasing salt on the structure and stability of Cyt R DNA Binding Domain (DBD). We observed that Cyt R gradually attains secondary and tertiary structure with increasing salt concentration. Cyt R displays a graded increase in structure, stability and folding rate on increasing the osmolarity of the solution that mimics the non-specific screening by DNA phosphates. The gradual structural acquisition is observed for almost all basic salts like phosphate, sodium chloride, potassium chloride and sodium sulfate. This property of Cyt R can be exploited to be used as soil salinity sensor.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Sneha Munshi, Indian Institute of Technology, Madras at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Anemia meter

Student of Amrita Vishwa Vidyapeetham, Coimbatore, Jeethu Raveendran won the award for research work of Anemia meter. They carried their project work under the guidance of Dr T. G. Satheesh Babu.

Anaemia is a disorder that affects over one billion people worldwide. Typically, anaemia is detected by examining the haemoglobin/haematocrit values. Generally, these tests were conducted using a haematology analyzer, haematocrit centrifuge or spectrophotometer. These instruments are expensive, non-portable, and require operation by trained personnel; they are therefore unavailable in many low-resource settings. These tests are also expensive and are not affordable by the common man. This indicates a requirement of accessible and affordable technology for anaemia detection. A simple battery-powered microhaematocrit centrifuge system with commonly available materials like DC motor, polyethylene terephthalate (PET) sheet, mounting hub, and screws was fabricated.

The development of the system is as simple as it can be assembled by any nontechnical personnel and can be used as an electric toy. This portable system could be used as a replacement for commercial benchtop centrifuge which is bulky and expensive. The device can be used as a simple anaemia reader. The system also has been employed for the estimation of haematocrit and using the haematocrit values the haemoglobin levels were calculated. The main advantages of the device are its simplicity and low cost which make this a global solution for haematocrit estimation, anaemia detection and serum-based diagnostics in resource free settings.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Jeethu Raveendran, Amrita Vishwa Vidyapeetham, Coimbatore at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Economical Paper-Strip For Early Stage Mastitis Disease Detection In Cow

Students of Sri Venkateswara Veterinary University, Tirupati (SVVU), Harika Chappa, Avisek Barla, Navin V Narayanan, Sudip Chakraborthy and Ahila Yegappan won the award for research work of Economical Paper-Strip For Early Stage Mastitis Disease Detection In Cow. They carried their project work under the guidance of Prof Y. Hari Babu.

Mastitis is an inflammation of the mammary gland in animal’s udder that adversely affects the animal health, therefore, leading to an annual economic loss of around $35 billion worldwide and 7615.15 crores rupees in India. Currently, the disease is detected in clinical settings by expensive techniques and also in places, which are miles away from remote villages.
The microfluidic paper-based analytical device fabricated for mastitis disease diagnosis in cattle is highly economical i.e. as low as Rs. 1/-, portable, ecologically compatible and self-diagnostic. It will help farmers to screen and monitor the most economically devastating mastitis disease in the bovine species at an early stage. The detection time of disease using the proposed method is 15 minutes approximately with high accuracy and efficiency. The major indicators of mastitis disease are the somatic cells, whose deformities are envisioned based on the qualitative and quantitative detection done on a paper-strip method.

The unique combination of the reagent and dye achieve a cost-effective solution. A drop of milk is to be added to the reagent incorporated paper strip having desirable pore size with hydrophobic nature, and incubated for about 10 minutes. Through the natural capillary action, the milk reacts with the reagent and provided dye is to be added. It will show an instant change in colour. Colour intensity is the measure of the prevalence of mastitis disease, captured by mobile camera and quantified by software or is self-descriptive through the naked eye. This paper- strip can be used by farmers, dairy industries, veterinarians, the households and regulatory agencies as an indicator of the safety and suitability of raw milk for consumption by humans and also preventing zoonotic diseases. Farmers can negotiate a good price with the dairy industry based on milk quality information from paper-strip and enhance the quality of life. Affordable Paper-strip can be utilised by relatively untrained people and it ensures laymen terms to deliver the best information and is complete with easy-to-understand information and enhance dairy industry contribution to Indian GDP.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Harika Chappa, Avisek Barla, Navin V Narayanan, Sudip Chakraborthy and Ahila Yegappan, Sri Venkateswara Veterinary University, Tirupati (SVVU), at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Fighting resistance in cancer cells due to bacterial infections with modular drug platforms: An idea towards personalized medicine

Student of Indian Institute of Technology, Delhi, Rohini Singh won the award for research work of Fighting resistance in cancer cells due to bacterial infections with modular drug platforms: An idea towards personalized medicine. They carried their project work under the guidance of Prof. Shalini Gupta.

The motive of the study is to target intracellular bacterial infection in cancer and analyse the impact of bacterial presence on the efficacy of chemotherapeutic drug. We observed that bacteria have the capability to biotransform the anticancer drug which might affect its activity and it is the reason for resistance in cancer cells. We have developed multifunctional liposomes with dual capability to simultaneously target cancer and cancer cell internalized bacterial cells. The liposomes are encapsulated with doxorubicin and surface is functionalized with an antibacterial peptide sushi S3 which is used as drug delivery vehicle as a proof-of-concept in an in vitro model. A realistic in vitro cell model was created in which Huh-7 liver cancer cells were infected with Salmonella typhi. It has been observed that S. typhi has the potential to cause gall bladder and liver cancers.

The efficacy of the drug delivery platforms has been tested on S. Typhi- infected liver cancer (Huh-7) cell models. The presence of S. Typhi definitely decreased the efficacy of dox against Huh-7 cancer cells. The overall efficiency to kill cancer and bacteria got improved by approx. 70% than free anticancer drug/anticancer alone when both compounds were given in the liposomal form. The efficacy of the nano-formulations can be enhanced by conjugating specific ligands expressed on cancer cells such as folic acid. We envision that such combinatorial platforms would definitely give a new direction in targeting co-existing infections with synergistic effects and help in curbing the drug resistance problem.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Rohini Singh, Indian Institute of Technology, Delhi at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

A more accurate detection and intrinsic subtype classification of breast cancer using machine learning.

Student of Indian Institute of Technology, Kharagpur, Bikash Ranjan Samal won the award for research work of A more accurate detection and intrinsic subtype classification of breast cancer using machine learning.. They carried their project work under the guidance of Dr. Ranjit Prasad Bahadur.

Breast cancer is a heterogeneous and complex disease, with a high mortality rate. It is one of the predominant cancer types that affect millions of cases and cause thousands of deaths every year in India. The effective treatment and prognosis of breast cancer development relies largely on a correct classification and also help patients in avoiding improper chemotherapy and undergo its side effects. In our studies, we developed a classifier to distinguish the five intrinsic subtypes of breast cancer using microarray gene expression profile data. The model is based on supervised learning using a support vector machine algorithm for classification.

The genes required for acting as the important features for classification were identified with a greedy algorithm i.e. recursive feature elimination method via logistic regression. We identified a panel of 40 genes which serve as the important features for classifying the breast cancer intrinsic subtypes, using their gene expression profile data. The modelled classifier has an accuracy score of 93-96% and it is more than the previous method. It has good precision, recall and F score for prediction. This method uses a minimal number of genes as features, which indicates that lesser the number of features, lesser will be the number of gene probes that can be used in diagnostic chips to detect breast cancer and its subtype. In the identified panel of genes, it is found that some of them are involved directly in the cancer process which may act as prognostic signatures.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Bikash Ranjan Samal, Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Proteasome Activation: A potential drug target for treatment of Parkinson’s Disease.

Students of Indian Institutes of Technology, Madras, Mohd Ahsan and P Chinmai won the award for research work of Proteasome Activation: A potential drug target for the treatment of Parkinson’s Disease. They carried their project work under the guidance of Prof. Sanjib Senapati.

Parkinson’s disease (PD), an age-dependent neurodegenerative disorder occupies a significant portion of the total disease burden of non-communicable diseases in our country. The accumulation of inclusion bodies/aggregation-prone proteins along with the loss of proteostasis eventually leads to death of neurons. Proteasome complex is known to be one of the key regulator of proteostasis in all the cells where the damaged and misfolded proteins are degraded. Recent studies have reported decreased proteasome function as a primary cause for many neurological diseases including PD. There are FDA approved inhibitors of proteasomal activity, however, development of proteasome activators is rarely looked at. One of the prime reason behind this is the complexity of human proteasome, limited understanding of the mechanism of activation. Hence, in our study, we exploited the archaeal proteasome complex through virtual screening and state-of-art molecular simulation techniques to decipher the mechanism of proteasomal activation by the HbYX motif (present in endogenous activators).

Results from our study showed that the extreme C-terminal residues (Tyr & Arg) of this motif directly participate in opening the central pore of the archaeal 20S complex. Arginine being the charged residue contributes more to the binding energy and tyrosine residue interacts with the N-terminal loop of each α subunit through a H-bond with the backbone of Gly19 (α subunit) side chain of Arg20 (α subunit). Thus, the dipeptide- Tyr-Arg is exploited as the initial lead for database screening followed by rigorous docking analysis. This extensive library screening resulted in three activator small molecules, working in both archaeal and human 20S complex. From our study we have successfully characterized the first lead chemical moieties as the potential proteasome activators. Hence, our results showed that the structurally simple archaeal 20S complex can serve as the ideal target for structure based drug-designing in order to find activators for the human 20S complex.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Mohd Ahsan and P Chinmai, Indian Institutes of Technology, Madras at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Production of effective and low cost dapsone-phytochemical hybrid candidate for use in multidrug therapy against Mycobacterium leprae

Student of Institute of Medical Sciences and Sum Hospital (IMS and Sum Hospital) Bhubaneswar, Shasank Sekhar Swain won the award for research work of Production of effective and low cost dapsone-phytochemical hybrid candidate for use in multidrug therapy against Mycobacterium leprae. They carried their project work under the guidance of Prof. Rabindra Nath Padhy, Prof. P. Sudhir Kumar.

Leprosy, the staggering infectious disease caused by the obligate intracellular Mycobacterium leprae continues to be the belligerent public health hazard for causation of high disability and eventual long-term morbidity, even treatment with ongoing multidrug therapy (MDT). From the vast ethnomedicinal records and ethnopharmacological investigations, phytochemicals are potent against infectious diseases; but, none of those has gone up to the pure-drug stage due to the lack of the desired drug-likeness values and the required pharmacokinetic properties. To overcome the drug-resistant problem, the improvement of the primary antileprosy sulfa drug, dapsone through chemical conjugation with a suitable phytochemical for reuse of dapsone in empiric antibacterial therapy is the primary goal. With various bioinformatics and chemoinformatics analysis, dapsone-phytochemical conjugates were synthesized adopting azo-dye coupling reaction, and structural interpretation was carried out by UV, FTIR, NMR, HPLC, LCMS, and SEM.

From the in vivo ‘mice-foot-pad-propagation’ study, the ‘dapsone-thymol’ hybrid product at the WHO recommended dose for dapsone, 0.01 % mg/kg reduced one-log bacilli-population in ‘dapsone-resistant’, and no bacilli were found in ‘dapsone-sensitive’ M. leprae infected mice foot-pad in three months of oral treatment. Additionally, from the in vitro host-toxicity study with cultured-human lymphocytes, it was confirmed that the dapsone-thymol conjugate was safe for oral administration up to 5,000 mg/L, since a minor number of dead cells were found under a fluorescent microscope. In conclusion, the newly synthesized ‘dapsone-thymol hybrid’ product could be used in a revised MDT in place of dapsone against M. leprae after successful validation in the clinical phase. Indeed, conjugation of a phytochemical with the obsolete drug could serve the new trend in current antibacterial drug development with resources and time saving through the ingenious combination of bioinformatics and medicinal chemistry tools.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Shasank Sekhar Swain, Institute of Medical Sciences and Sum Hospital (IMS and Sum Hospital) Bhubaneswar at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Design and development of interlock mechanism based bio-compatible, user-friendly and cost-effective elbow disarticulation prosthesis

Students of Indian Institute of Technology, Guwahati, Mrutyunjay Maharana and Bhabani Shankar Nayak won the award for research work of Anti-Pesticide Dermal Gel. They carried their project work under the guidance of Dr Sisir Kumar Nayak.

 

 

 

 

 

 

 

 

 

The upper limb amputation is a serious problem for human as it causes hindrance to various daily activities. Especially for the elbow amputation, it causes severe damage to the movement of the hand for a different common purpose. The available prosthetic elbow and disarticulation prosthesis are very costly and cannot be afforded by the common and economical backward people in India. By realizing the extreme requirement of elbow amputee people’s usability and affordability, the design and development are carried out for interlock mechanism-based bio-compatible, user-friendly and cost-effective elbow disarticulation prosthesis. There is no complicated electronics and motorized actuation involved therefore it makes this design simple. This design incorporates the internal slot mechanism which will provide an adequate motion of the artificial hand connected to the elbow joint. The joint is developed mechanically which helps the prosthesis to bring back sound gait of elbow and hand similar to the normal elbow. The design is very compact and not exposed outside of the hand so that normal clothing for the patient is not hampered. The design of an elbow joint incorporates a simple machining and manufacturing process for easy fabricated. Most importantly, the cost of the prosthetic joint is around Rs.1500-2000/unit by machining of a single unit. However, the cost can be further reduced by mass production. Since the innovation is focused on the mechanical linkage based low-cost prosthesis, this innovation will certainly benefit the elbow amputee people to bring back their normal hand gait cycle. Commercialization of this innovation is going to serve the majority of the elbow amputees. As the development is specified for a very unique group of specially-abled people, the implementation of this will have a positive impact on society.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Mrutyunjay Maharana and Bhabani Shankar Nayak, Indian Institute of Technology, Guwahati at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Development of improved biocatalysts for D-allulose production utilizing the low-cost agro-industrial residues

Student of Center Of Innovative and Applied Bioprocessing(CIAB) Punjab, Satya Narayan Patel won the award for research work of Development of improved biocatalysts for D-allulose production utilizing the low-cost agro-industrial residues. They carried their project work under the guidance of Dr Sudhir P. Singh.

D-allulose (D-psicose) is a C3 epimer of D-fructose. It is a rare sugar having 70% of the relative sweetness of table sugar. It exerts only 0.3% calories of table sugar. Consumption of this sugar is beneficial to human health in several ways i.e. anti-obesity, anti-diabetic, anti-oxidative, hypoglycemic, anti-dyslipidemic, and neuro-protective effects. It improves the texture of food materials with pleasant flavour through the Maillard reaction. The team has developed a novel enzyme- systems for the biosynthesis of D-allulose from D-fructose. A fusion of yeast Smt3 at the N-terminus of Agrobacterium tumefaciens D-allulose 3-epimerase improved thermal tolerance of this enzyme by several folds. This modified chimeric protein was covalently attached to the magnetic nanoparticles. This nanoparticle-enzyme conjugation system was demonstrated to be more thermo-stable and recyclable. Recently, we have discovered a novel gene encoding D-allulose 3- epimerase enzyme from the metagenomic information of a thermal aquatic habitat of extreme temperature. The protein sequence of this novel enzyme exhibits significant dissimilarity with any known protein in the public databases. This novel biocatalyst shows excessive thermal stability at 50-60 °C temperature, which is considerably higher than any D-allulose 3-epimerase enzyme known till date. These bio-catalytic systems have been used to bioprocess several agro-industrial wastes (e.g. fruit pomace, cabbage waste, banana pseudostem, and cane molasses) for the transformation of in-situ D-fructose into D-allulose.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Satya Narayan Patel, Center Of Innovative and Applied Bioprocessing(CIAB) Punjab at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Towards Application of Helical Nanorobots for Biomedical Applications.

Students of Indian Institute of Science, Bangalore, Malay Pal, Debayan Dasgupta, Arijit Ghosh and Neha Somalwar won the award for a research work of Towards Application of Helical Nanorobots for Biomedical Applications. They carried her project work under the guidance of Prof. Ambarish Ghosh, Dr Deepak K Saini, Prof. Ramray Bhat.

Magnetically driven nanorobots have gained immense interest for biomedical applications because of its wide range of potential applications. The team is working on helical shaped magnetic nanorobots that can be internalised by the cells when incubated for around 24 hours. Subsequently, these internalised nanorobots can be actuated remotely inside the living cell by application of a rotating magnetic field. This novel technique of intracellular manipulation is completely benign to the living cells which has been confirmed from cell viability studies. Our work also confirms that these tiny nanorobots can promptly detect changes in local environment inside a living cell which is very promising for new studies in cell biology and new techniques for sensing of an intracellular matrix. Another important application of helical magnetic nanorobot is that it can sense viscosity of the surrounding environment with high Spatio-temporal resolution as it moves through the medium. This active measurement is much faster than conventional passive rheological technique. Along with its ability to be positioned in any arbitrary location within the fluid medium, it is now possible to find out local heterogeneities in the medium very easily. Any other parameter that causes a change in viscosity of the medium, for example, temperature, can also be measured using this active system. The current method can be applied to both Newtonian and Shear-thinning fluids which is an added advantage as most of the biological fluids are also shear thinning. Above two results suggest that helical magnetic nanorobot is an appropriate candidate for future biomedical applications. We are exploring further for other exciting features of the helical magnetic nanorobots. Hopefully, in a few years, we shall witness a paradigm shift in the biomedical industry with the help of these nanorobots.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Malay Pal, Debayan Dasgupta, Arijit Ghosh and Neha Somalwar, Indian Institute of Science, Bangalore at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Development of low grain arsenic rice by the fungal arsenic methyltransferase via bio-volatilization

Students of CSIR – National Botanical Research Institute, Lucknow, Shikha Verma and Dr Pankaj Kumar Verma won the award for a Development of low grain arsenic rice by the fungal arsenic methyltransferase via bio-volatilization. They carried their project work under the guidance of Dr Debasis Chakrabarty.

Numerous studies have been extensively documented for the benefits of Continuous Subcutaneous Insulin Infusion (CSII) over Multiple Daily Injections (MDI) for insulin therapy in Type 1 Diabetes Mellitus (T1DM) patients. Despite such overwhelming evidence in support, the adoption of CSII is sparse, particularly in resource-constrained settings like India. Apart from the institutional factors, fixed and recurring costs of such a device are often found to be a withholding factor for widespread application. The abstract describes the development of a novel, affordable insulin pump for T1DM patients matching the specifications of a state-of-the-art pump, while significantly bringing down the fabrication cost. Most pumps rely on a lead screw/nut coupled with a geared DC motor to achieve precise micro-motion. These motors typically make use of micro-gears as a means of speed reduction, which is inherently expensive to manufacture. Consequently, they contribute significantly to the final cost of a pump. In this work, we take an innovative approach to distribute the requisite speed reduction in multiple stages, with an acceptable compromise on the product size. The system is actuated by a nominal DC geared motor and a novel mechanism of converting continuous rotary input to intermittent output. The kinematic chain is feedback-controlled which ensures volumetric accuracy of the delivered fluid. The pump can be wirelessly controlled via a remote. The same wireless channel can be used to connect to a Continuous Glucose Monitoring (CGM) device for subsequent integration with an Artificial Pancreas system. Preliminary accuracy tests showed promising results when compared with commercially available devices.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Shikha Verma and Dr Pankaj Kumar Verma, CSIR – National Botanical Research Institute, Lucknow at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Developing Labscale Magneto-Mechanical Experimental Setup to Predict the Plaque Growth of Human Heart Coronary Arterial Layer System

Student of Madanapalle Institute of Technology and Science (MITS) Andhra Pradesh, Mallikarjunareddy Reddy Boreddy won the award for a Developing Labscale Magneto-Mechanical Experimental Setup to Predict the Plaque Growth of Human Heart Coronary Arterial Layer System. They carried their project work under the guidance of Dr Mallikarjunachari G.

In India, one out of six men and one in ten women die from heart disease and the death rate is significantly increasing day by day. According to present estimates, India will soon have the highest number of heart disease cases in the world. Conferring to the Indian Heart Association, 50% of all heart attacks in Indians occur under 50 years of age, and 25% of all heart attacks in Indians occur under 40 years of age. One of the primary reason for coronary heart disease is the growth of plaque in the heart arterial wall layers. The ratio of a number of heart patients to the available specialized cardiovascular doctors is significantly high. Moreover, the average cost of a less severe heart attack is about £ 600,000. All the above statistics indicate that the necessity of escalating the research in human heart artery system. In this regard, developing cost-effective experimental setup is an alternative way to fulfil the need. The identification and removal of plaque at the initial stages further bring down the cost significantly. Developing a labscale magneto-mechanical device to predict the plaque growth of human heart coronary arterial layer system. Plaque is the fatty (waste) substance that forms in between the heart arterial wall layers. The growth of this plaque at the interface of the layers blocks the blood flow and finally leads to a heart attack or stroke. Identification of the plaque growth at the interface is one of the major challenges for the biomedical research community. Our team is very confident that this study will be extremely useful to researchers from the area of biomedical science, material science, interface biology and also from nanoengineering.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Mallikarjunareddy Reddy Boreddy, Madanapalle Institute of Technology and Science (MITS) Andhra Pradesh at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Artificial Bio-markers of Knee Osteoarthritis

Student of Indian Institute of Technology, Delhi, Nikhil Gupta and Dr Alok Prasad won the award for an Artificial Biomarkers of Knee Osteoarthritis. They carried their project work under the guidance of Prof. Tapan Kumar Ghandhi
Knee osteoarthritis is a chronic, progressive disease characterized by the loss of cartilage in joints. It is one of the biggest problem affecting a large number of elderly people today. Commonly, orthopaedics use radiographic techniques like X-ray, CT-Scan, MRI etc. to look for the deterioration in cartilage or damage in the bones. But, it has been found out that almost 50% of patients with symptomatic Knee, OA shows no signs in radiographs because of the low sensitivity of these diagnostic tools. The lack of biomarkers of knee OA and 35+ different ways a patient describing the pain leads to a lot of subjectivity in the diagnosis, lack of specific treatment for patients, and poor quantification of post-treatment stage. We have created an IOT enabled device which in congestion with a sophisticated machine learning algorithm that detects Knee OA at an early stage from the walking pattern of a subject. The device collects 1000+ data points about the walking pattern and learns to create features which categorize the patient as per their medical condition. This high touch solution can greatly help caregivers & doctors to understand the complication in a comprehensive manner. Doctors can now suggest much better treatment with specific supplements, drugs, and surgical recommendations. This device in combination with an app will be highly useful specifically to early-stage subjects to help them track their disease condition and actually see themselves improving due to the results of management measures they are taking.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Nikhil Gupta and Dr Alok Prasad, Indian Institute of Technology, Delhi at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Novel and Eco-friendly lightweight Thermal Insulating Ceramics from Thermal Power Plant Waste

Student of Institute of Chemical Technology, Mumbai, Yogesh D. Urunkar and Chandrakant S. Bhogle won the award for a Novel and Eco-friendly lightweight Thermal Insulating Ceramics from Thermal Power Plant Waste. They carried their project work under the guidance of Prof. Aniruddha B. Pandit and Prof. J.B. Joshi.

India alone produces 169 MT of the fly ash per annum from 155 thermal power stations, out of which 50% were unutilized and dumped into the land. This may cause catastrophic effects on the environment. Therefore, it is very much essential to utilize this fly ash in a novel, eco-friendly and economical way. This innovation targets the problems caused by fly ash due to its non-utilization and provides a sustainable and practical alternative to the existing ceramic material. The developed fly ash ceramic material has unique properties such as it is an ultra-thermal insulating and very lightweight. The density of the developed material is 0.6- 0.8 g/cc so that it can also float on the water.

Its thermal conductivity varies from 0.2-0.5 W/m.k which is four to ten times better compared to the existing ceramic materials. Apart from this, it can be moulded into any size and shape and provides good mechanical strength. The raw material, which is fly ash, abundantly available at zero cost. All these miraculous combinations of desired properties makes it very attractive alternatives to the existing ceramics. Therefore, developed ceramic can be used in the construction & building as roof tile, wall tile, roofing sheets, industrial thermal insulation, decorative pottery items, variety of other applications.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Yogesh D. Urunkar and Chandrakant S. Bhogle Institute of Chemical Technology, Mumbai at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Early Diagnosis of Osteoporosis Using Metacarpal Radiogrammetry and Texture Analysis

Student of National Institute of Technology, Surathkal (NIT), Anu Shaju Areeckal won the award for a Early Diagnosis of Osteoporosis Using Metacarpal Radiogrammetry And Texture Analysis. They carried their project work under the guidance of Prof. Sumam David S.

Osteoporosis is a disease characterized by a reduction in bone mass and micro-structure, causing a high risk to fragility fractures. The gold standard diagnostic technique for osteoporosis, Dual Energy X-ray Absorptiometry (DXA), is expensive and not widely available in India. We developed a low cost prescreening tool for early diagnosis of osteoporosis using hand and wrist radiographs. Automated segmentation method for extraction of third metacarpal bone and distal radius is developed. Cortical radiogrammetry of third metacarpal bone and texture analysis of distal radius is done and the most significant features are used to train classifiers. The pre-screening tool is validated using 138 subjects from the Indian sample population. The segmentation method shows a detection accuracy of 89% and 93.5% for the third metacarpal bone shaft and distal radius, respectively.

The trained artificial neural network (ANN) classifier achieves the best test accuracy of over 90.0%. A linear regression model shows a significant correlation of 0.671 with DXA. A novel low-cost technique to measure cortical bone volume using three dimensional (3D) reconstruction of metacarpal bone is also developed from hand radiographs in three views. Projections of the 3D reconstructed models are compared with manually segmented X-ray images of 20 subjects. The mean error percentage in combined with cortical thickness is 11.2%. The pre-screening tool is a promising technique to identify people with low bone mass and will enable mass screening of people in primary health centres in non- urban areas where DXA is unavailable. This work is done in collaboration with Kasturba Medical College (KMC) Hospital, Mangalore, India and University Hospital of Geneva, Switzerland. The study protocol was approved by the Institutional Ethics Committee, KMC Hospital, Mangalore, Manipal Academy of Higher Education, India.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Anu Shaju Areeckal National Institute of Technology, Surathkal (NIT) at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Formic Acid-Powered Ferrobots For Clean Energy Technology

Students of Indian Institute of Technology, Guwahati, Amit Kumar Singh, Saptak Rarotra and Viswanath Pasumarthi won the award for a Formic Acid-Powered Ferrobots For Clean Energy Technology. They carried their project work under the guidance of Prof. Dipankar Bandyopadhyay and Prof. Tapas Kumar Mandal.

Hydrogen fuel cells work by instigating stored hydrogen to react with oxygen in the air, producing electricity and water. However, generation of pure hydrogen fuel can be a challenging problem. The large-scale production of hydrogen gas is mostly achieved by steam-methane reforming. The major drawback of steam reforming is that – (i) it takes place at high temperature and thus requires external heat energy to maintain elevated temperature and (ii) process results in emission of greenhouse gases as a by-product of the reaction. Furthermore, hydrogen storage and transportation is expensive and requires exclusive tanks to store gas at enormously high pressure. In order to address this issue, we report chemically powered micromotors composed of a collection of iron nanoparticles (FeNPs), namely ferrobots, for rapid on-site generation of pure hydrogen gas using formic acid as fuel.

Instead of storing hydrogen gas in bulky pressurized tanks, motile ferrobots could be easily deployed into aqueous formic acid solutions for on-demand release of pure hydrogen gas, devoid any of greenhouse gases, at room temperature. To demonstrate the proof-of-concept, reactive ferrobots were employed to power a portable toy fan equipped with PEM fuel cell. The pure hydrogen gas required for PEM fuel cell was generated through reaction of a formic acid solution with self-propelling ferrobots, whereas, oxygen gas was produced by catalytic decomposition of peroxide fuel using same ferrobots. The as- generated hydrogen and oxygen gases were directly fed from reaction chambers to the fuel cell electrodes to generate electricity and thus power electronic toy fan. The advantage of this type of micromotor-mediated system is that liquid fuels are used for on-site hydrogen release, and thus gas storage will not be prerequisite in the near future.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Amit Kumar Singh, Saptak Rarotra and Viswanath Pasumarthi Indian Institute of Technology, Guwahati at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Dual action of SPIONS in effective removal of heavy metals and mosquito larvae from water.

Student of Sathyabama Institute of Science and Technology, Chennai, Roshini S. M., Karthika M.and Lavanya Agnes Angalene J. won the award for a Dual action of SPIONS in effective removal of heavy metals and mosquito larvae from water. They carried their project work under the guidance of Dr. Antony V Samrot.

Water is vital for all known forms of life. Due to industrialization and improper effluent disposal, the natural water bodies in many parts of our country are alarmingly contaminated with heavy metals like Cd, Cr, Cu, Ni, As, Pb and Zn which are well known for their toxic impact to environment and human health. In the case of mosquitoes, it is reported that the presence of heavy metals enhances the breeding potency thus supporting the outbreak of various life-threatening diseases like malaria, chikungunya, yellow fever and dengue. Here with the support of Nanotechnology, a commercially available larvicide is used to eradicate the mosquito larvae as well as effectively remove the heavy metals from its breeding platform, water. Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) are employed as the core carrier molecules which are nanoformulated to achieve the dual action.

Chemically synthesized SPIONs are surface modified and tagged with a commercially available larvicide, further encapsulation was performed using a biopolymer. The biopolymer encapsulation of the tagged-SPIONs helped the nanoformulation to accomplish stability and also offer biocompatibility. The biopolymer and SPIONs help in the heavy metal removal and eventually the tagged larvicide exhibit its lethal action against the target, mosquito larvae. Since SPIONs are magnetic nanoparticles, the application of magnetic field eases the removal of both SPIONs incorporated dead larvae and the targeted heavy metal after treatment. This action not only minimizes the release of larvicide in water but also removes the targeted heavy metals and mosquito larvae, thus making the water favourable for use. The ultimate goal of this innovation is to design a unit in association with conventional water treatment filters to bring out the aforementioned dual action and ensure the supply of heavy metal free and larvae free water

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Roshini S. M., Karthika M. and Lavanya Agnes Angalene J. Sathyabama Institute of Science and Technology, Chennai at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Non-catalytic deep desulfurization process using hydrodynamic cavitation

Student of CSIR-National Chemical Laboratory, Pune (CIR-NCL), Nalinee B. Suryawanshi won the award for a non-catalytic deep desulfurization process using hydrodynamic cavitation. They carried their project work under the guidance of Dr Vinay M. Bhandari.

Deep desulphurization of various organics, in general, and transportation fuels, in particular, is a demanding operation, especially from pollution point of view. In this work, a green approach is undertaken for desulfurization of fuels or organics without the use of catalyst or external chemicals/reagents/oxidizing agent using a simple methodology of hydrodynamic cavitation. The process involves pre-programmed mixing of the organic and aqueous phases and can be carried out using simple mechanical cavitating devices such as vortex diode (patented by our group) and orifice. Three organic solvents (n-octane, toluene and n-octanol) containing a known amount of a model sulphur compound (thiophene) up to initial concentrations of 500 ppm were used to verify the proposed method. Very high removal of sulfur content to the extent of 100% was demonstrated. The results were also verified and substantiated using commercial diesel as a solvent. The nature of the organic phase and the ratio of aqueous to organic phase were found to be the most important process parameters.

The developed process has great potential for deep desulfurization of various organics, in general, and for transportation fuels, in particular. The estimated operating cost of  desulfurization using hydrodynamic cavitation is far lower than the present refinery hydrodesulphurization process and adsorptive desulfurization process. The aqueous phase used in the proposed method can be recycled after removing a purge stream (with corresponding make-up water). The process offers many advantages, most importantly ease of operation and mild operating conditions for effective sulphur removal. The proposed method can be effectively implemented for large scale deep desulphurization operations.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Nalinee B. Suryawanshi CSIR-National Chemical Laboratory, Pune (CIR-NCL) at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Utilisation of Real-World Waste Plastic for the Production of Fuel Range Liquid Hydrocarbons using Two-step approach

Student of Indian Institute of Technology, Delhi, Uma Dwivedi won the award for a Utilisation of Real-World Waste Plastic for the Production of Fuel Range Liquid Hydrocarbons using a Two-step approach. They carried their project work under the guidance of Prof. K. K. Pant, Prof. S. K. Naik.

A large amount of waste plastics is being generated because of the accessible properties of the plastics. However, due to lack of efficient end-of-life management in many developing countries; plastics are now posing serious threats to the environment and human health due to its non-biodegradable nature. Liquid fuel formation through thermo-catalytic cracking can provide a good platform for the energy recovery by making use of dumped plastics. The process involves designing an improved two-stage batch reactor system, an effort for the replacement of petro-diesel compounds which covers the synthesis of highly active heterogeneously modified zeolite that supports the catalysts for effective breakdown of waste plastic. The developed two-step approach leads to the 100% conversion of waste plastic into value-added products comprising 60 to 80% liquids, and 20 to 35% gases at a temperature range of 300-350°C.

The results suggest that the carbon chain length was narrowed to C 5 -C 28 when the zeolite catalysts were employed, as well as the significant yield of a controlled fraction of paraffins, olefins and aromatics,  was obtained indicating that the obtained liquids are fuel-like products. The liquid fuel formed is expected to be an effective renewable fuel as supported with the comparable results of GC-MS, 1 H and C 13 NMR, Heating value, Proximate analysis, etc. which can be used as an alternative source of fuel for the IC engine operation. However, the usage of the developed catalyst shows the added advantages of reducing the cracking temperature as well as tailoring the selectivity. Eventually, it should be noted that the negative impacts of waste plastics could be addressed or minimized by recognizing the fact that waste plastics have great potential for resource conservation when converted into a valuable resource.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Uma Dwivedi Indian Institute of Technology, Delhi at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Development of Rapid and Non-destructive Method for Detection of Insect Infestation in Stored Cereal Grains

Student of Indian Institute of Technology, Kharagpur, Gayatri Mishra and Ranjana Rani won the award for research work of Development of Rapid and Non-destructive Method for Detection of Insect Infestation in Stored Cereal Grains. They carried their project work under the guidance of Dr H N Mishra and Shubhangi Srivastava.

India is the second-largest producer of cereal crops in the world but, with the existing facilities, negligible part contributes to post-harvest losses. In this aspect, insect infestation is an alarming concern, accounting for losses in quality as well as quantity. A major portion of the post-harvest losses can be saved by detecting the insects in their early developmental stages and subsequent application of suitable disinfestation approach is undertaken for their control. The current scenario demands rapid methods for insect detection, which can take a lead over conventional methods, on the ground of promptness, usability, non-destructiveness, affordability of start-up cost, and implementation feasibility beyond the laboratory domain. In this study, rapid methods were developed using Fourier transform near-infrared spectroscopy (FTNIR), electronic nose (E-nose), and hyperspectral imaging techniques.

The methods were then statistically compared to select the most suitable technology for the development of a portable sensor assembly for detection of insect infestation of stored cereal grains (i.e. rice, wheat, and maize). E-nose was chosen among the various techniques and the experimental findings were adapted for the development of a low-cost portable sensor. Based on the findings, alcohol and ammonia sensors were integrated with a microcontroller unit to fabricate the sensor assembly, which was effective enough to detect the level of infestation based on the headspace gas composition. The outcome of the project will lead to a convenient, rapid yet nondestructive approach for quality determination of insect-infested cereal grains at various stages during the storage. The sensor will be a boon for developing countries like India to rapidly detect the infestation precisely and support the ideology “saving a grain is producing a grain”.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Gayatri Mishra, Ranjana Rani  Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Image Analyzing Drying Patterns of Blood And Plasma Droplets For The Rapid Detection of Thalassaemia Carriers

Students of Indian Institute of Technology, Kharagpur, Manikuntala Mukhopadhyay and Rudra Ray won the award for a research work of Image Analyzing Drying Patterns of Blood And Plasma Droplets For The Rapid Detection of Thalassaemia Carriers. They carried her project work under the guidance of Prof. Sunando DasGupta and Prof. Maitreyee Bhattacharya.

Thalassaemia is one of the most common single-gene disorder in which the production of haemoglobin is impaired. This autosomal recessive disorder is highly prevalent in Indian populations accounting to ~10% of the world’s thalassaemia carriers. The beta-thalassaemia carrier state resulting from a heterozygous mutation in the beta-globin gene is clinically asymptomatic and thus remain undiagnosed. At present, the gold standard method that is used for carrier detection in hospitals requires expensive instruments, skilled manpower and time, thus, making it difficult to be used as an onsite method. A rapid, portable and automated technology for thalassaemia carrier screening is hence of significant importance. The present study has conclusively proven the distinct patterns observed on the drying of whole blood droplets for carrier and normal samples. Length of the radial cracks is significantly shorter for carrier samples as compared to normal ones. A sample whose average crack length is less than 800 microns can be classified as a carrier sample, whereas the ones with larger radial cracks are considered as normal. Identifying the carrier samples by this image analysis technique gave zero false-negative results.

 

 

 

 

 

 

 

 

 

 

 

These patterns can be further utilized to create a databank for automated classification of carrier samples, by employing appropriate techniques from computational pattern recognition and deep learning. The proposed method will examine the images of dried blood drops, extract its distinctive features and categorize as normal or carrier samples by comparing it with reference images stored in a databank. This automated process will remarkably increase the number of the total population screened for thalassaemia per year in the country and will reduce the burden on the state-run advanced health facilities along with a significant reduction in costs incurred for a screening of each sample.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Manikuntala Mukhopadhyay and Rudra Ray, Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Actin Mimetic ATP Driven Controlled Supramolecular Polymerization

Student of Jawaharlal Nehru Centre for Advanced Scientific Research, Ananya Mishra won the award for a research work of Actin Mimetic ATP Driven Controlled Supramolecular Polymerization. She carried her project work under the guidance of Prof. Subi J. George.

The need of supramolecular systems with increased complexity and structural control is growing in the direction of intriguing functions similar to their biological analogues like DNA and cells. The question, “How far can we push self-assembly?” is recognized as one of the biggest-challenges in supramolecular material science. This work describes a synthetic organic molecule, oligophenylene vinylene functionalized with dipicolyl ethylene diamine (OPVDPA), coming together and stacking on each other in a helical sense on electrostatic interaction with a biological cue, ATP.

This process is very close to events occurring in nature that notably help a cell to maintain its shape, i.e. actin, which undergoes ATP driven temporal polymerization and dynamic instability. The study has come closest in synthetically mimicking this natural process. We have employed the facets of supramolecular chemistry as the area of investigation in this study, which deals with the interplay of non-covalent interactions for self-assembly. Though in synthetic systems it is a fairly new field, most biological processes function are based on these principles. In this context, systems driven by ATP became an inspiration for the team to work further. These systems are uniquely size-controlled over kinetic regimes which allow fascinating stimuli responsiveness and adaptability that could not have been achieved in synthetic systems before. Since the stimulus, in this case, is one of the most ubiquitously present chemicals such as ATP, therefore the study is a benchmark for what can be achieved synthetically. Furthermore as mentioned earlier the prospect of functional accessibility also makes the work more interesting.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Ananya Mishra, Jawaharlal Nehru Centre for Advanced Scientific Research at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Pneumatic Damping Prosthetic Leg For Above-knee Amputees

Students of MES College of Engineering, Kuttipuram, Muhammed Janish and Abhijitnath won the award for a Pneumatic Damping Prosthetic Leg For Above-knee Amputees. They carried her project work under the guidance of Prof. Padmakumar K.

The prime focus of the project is to design cost-effective feedback based on the prosthetic leg for above-knee amputees. Currently, the majority of amputees in India depend on functionally low mechanical legs like Uni-axial knee, ReMotion knee, Jaipur limb, etc. As the cost of a high functional feedback-based leg is around 70000 dollars, therefore, mechanical prosthesis like Uniaxial Knee, ReMotion limb restricts to locks which transfer the load to the ground. The major default of the currently available prosthetics lies in the restricted application, where the patient cannot use it in a bent position when the load is acting normal to the ground, as the lock won’t be working and the patient will stumble.

Also, mechanical legs won’t give any walking assistance as they only provided support & drains more energy. A proportional solenoid valve has been incorporated to control the pneumatic damping system in a mechanical knee. Force sensor at the foot detects the pressure applied by the amputee and adjust the damping resistance at the knee which enables the proposed device to lock the knee joint at any angle and position correspondingly so the amputee can transfer the load to the ground even in a bent position of the leg. Compressed air inside the pistons absorb shock during the stance phase of walking and provide walking assistance during starting of the swing phase of walking and all these applications draw less energy.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Muhammed Janish and Abhijitnath MES College of Engineering, Kuttipuram at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Patient-specific spheroid-on-chip for cancer treatment: combinatory drug screening

Student of Indian Institute of Technology, Hyderabad, Sharanya Sankar and Viraj Mehta won the award for a Patient-specific spheroid-on-chip for cancer treatment: combinatory drug screening. They carried their project work under the guidance of Dr Subha Narayan Rath.

Screening tumor biopsies from cancer patients and finding the appropriate drug combinations to treat the disease at various stages has been a challenge owing to the failure of the in-vitro cancer models to recapitulate the native tissue microenvironment of tumors. The prominence of this work lies in the development of a personalized healthcare set-up for cancer diagnostics and treatment for a patient-specific tumor sample. We have developed a microfluidic platform with strategically placed U-shaped wells for screening the combinatory effect of drugs on tumor spheroids. Also, the optimal flow conditions similar to the in-vivo flow regimes have been simulated. This set-up has inlet ports to provide a continuous flow of media through it to mimic the tumor microenvironment in-vivo. The outlet ports would prevent the back-flow of the excess fluid and maintain the flow conditions inside the wells. The platform allows self-formation of tumor spheroids on passing the cancer cells through the inlet port. Due to the continuous flow of media, the conditions in the well would not be static as compared to the existing models and provide physiologically relevant data with accurate predictive results. Further, the chip can be re-used by sterilizing it through simple techniques making it cost-effective and affordable. Hence, patient-specific tumor samples can be tested in the chip paving a way to create personalized profiling of drugs and their concentration for the treatment. Till date, standard drug treatments are administered to patients suffering from cancer irrespective of their conditions. This system would be a customized set-up to treat individual patients for their specific conditions. This would be a quick and effective approach in treating the fast progressing life-threatening disease. This innovation would be an invaluable step for developing an affordable healthcare set-up for cancer diagnostics and treatment.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Sharanya Sankar and Viraj Mehta Indian Institute of Technology, Hyderabad at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Real Time Surrogate Visual Tracking of Lung Tumours for Effective Radiotherapy

Student of Indian Institute of Technology, Kanpur, Priya Singh, Darshan Ramesh Shet won the award for research work ofReal Time Surrogate Visual Tracking of Lung Tumours for Effective Radiotherapy. They carried their project work under the guidance of Prof. Venkatesh K Subramanian.

A cost-efficient solution to improve the accuracy of radiotherapy given to lung cancer patients. Radiotherapy is a common recourse for treating lung tumors, being considerably more localised than chemotherapy. It, however, faces the challenge of maintaining the focus of the radiation beam on the tumor. Due to physiological factors like respiratory motion, peristaltic motion, cardiac motion, coughing etc, the tumor and its surrounding tissue inside the thorax or abdomen can move dynamically, with a displacement of up to 3 cm. The result of such movement, if ignored during radiotherapy, is the exposure of surrounding healthy tissue and organs, causing severe damage to them.

This research provides a solution by real-time surrogate visual tracking of lung tumours in all the phases during radiotherapy. To achieve a precision simultaneous acquisition of two types of data was done for visual chest surface data and x-ray data of the tumour. To perform visual surface tracking, an array of 4 cameras in conjunction with an adequate number of visible markers were implemented to capture the time evolution of the surface motion. The x-ray tracking of the tumour is performed using a CT scanner. Using the time synchronised x-ray and visual surface tracking data sets, we have built a time and space correlation model of the surface of the chest with the x-ray tracker data using Machine Learning. The patient can be subjected to radiotherapy with beam steering (currently used in hospitals) directed by the surrogate measurements from the correlation model that we have developed. This provides a more accurate, and less expensive method to maintain the radiation focus than the standards used today. Any innovation in the medical field demands extensive trials before adoption. We are seeking the cooperation of SGPGI, Lucknow to provide the infrastructure and subjects for the calibration step.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Priya Singh, Darshan Ramesh Shet, Indian Institute of Technology, Kanpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

 

Growth factor free strategy for therapeutic neo-vascularization

Student of Indian Institute of Technology, Madras Shivam Chandel and Abel Arul Nathan S won the award for a Growth factor free strategy for therapeutic neo-vascularization. They carried her project work under the guidance of Dr. Madhulika Dixit.

Endothelial progenitor cells (EPCs), a subset of circulating mononuclear cells are currently being studied as candidate cell sources for revascularization strategies. Increasing the number and/or improving the function of EPCs may be promising in the treatment of atherosclerotic disease, ischemia or Heart Failure. Current therapies for neo-vascularization are based on the administration of growth factors and nitric oxide donors. Administration of NO-donors has been promising but failed to promote neo-vascularization particularly in elderly and diabetic patients. Several clinical studies using growth factors have failed in phase II which successfully passed phase I, either due to their short half-lives or due to their harmful side effects. Studies have shown that application of fluid shear stress induces the differentiation of mononuclear cells to endothelial cells. Shear stress also enhances capillary blood flow and modulates the function and expression profile of angiogenic genes. However, the effect of shear stress on the circulating mononuclear cells is not well characterized. Hence, to study the effect of shear stress on the angiogenic potential of circulating mononuclear cells, a cone plate-based instrument assembly has been developed. This study focuses to enhance the angiogenic potential of mononuclear cells through ex-vivo preconditioning via application of shear stress.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Shivam Chandel and Abel Arul Nathan S, Indian Institute of Technology, Madras at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

 

Low-cost, easy-to-use, in-house developed electric cell impedance sensing (ECIS) system for studying the dynamic behaviour of the biological cell

Student of Indian Institute of Technology (Banaras Hindu University), Varanasi, Uvanesh Kasiviswanathan won the award for research work of Low-cost, easy-to-use, in-house developed electric cell impedance sensing (ECIS) system for studying the dynamic behaviour of the biological cell. He carried their project work under the guidance of Prof. Neeraj Sharma, Dr Sanjeev Kumar Mahto.

Physiological properties of each and every living organism (either diseased or normal) changes randomly with the external environmental conditions. Thus, the continuous monitoring of these properties is crucial for both long and short term analysis of any particular in vivo models. Generally, a large number of animals are used as in vivo models to analyse and predict the effect of various synthesized/formulated moieties and moreover they are being sacrificed as and when required during the drug screening process. In addition, in the pre-clinical and clinical trials/stages such step leads to a huge failure rate not only due to differences in the in vitro and in vivo models selected but also because of the incompatibility issues concerning to the sensing devices utilized for both the models.

Thus, an improved measuring/screening platform that can interface with both the in vitro and in vivo models need to be developed for measuring the dynamic behaviour of any biological cell/system. This study has designed and fabricated a low-cost, easy-to-use, portable electric cell impedance sensing (ECIS) system that shows great potential for analysing the physiological parameters in real-time both for in vitro and in vivo models. It is important to note that our device, by any means neither affects nor influences the biological models being tested. Further, the experimental data can be correlated with the physiological parameters through a theoretical calculation of the lumped-elemental electrical parameters of cell-electrolyte interface and metal-electrolyte interface.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Uvanesh Kasiviswanathan, Indian Institute of Technology (Banaras Hindu University), Varanasi at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Revelation of G-quadruplex formation as a molecular basis of fragile X tremor/ataxia syndrome (FXTAS) leads to a new direction in the drug discovery

Students of Indian Institute of Technology, Hyderabad Yogeeshwar Ajjugal and Narendar Kolimi won the award for research work of Revelation of G-quadruplex formation as a molecular basis of fragile X tremor/ataxia syndrome (FXTAS) leads to a new direction in the drug discovery. They carried their project work under the guidance of Dr Thenmalarchelvi Rathinavelan.

Trinucleotide repeats belong to the family of microsatellites (a tract of 1 to 6 repetitive nucleotides) that are commonly observed in eukaryotes and exhibit repeat length polymorphism. The inherent ability of trinucleotide repeats is to undergo abnormal expansion (viz. increase in repeat length) which leads to many incurable genetic disorders that are mainly neurodegenerative.

For instance, CGG repeat overexpansion in the 5’ untranslated region (UTR) of fragile mental retardation (fmr1) gene from unusual nucleic acid conformations and it causes genetic instabilities. This results in fragile X syndrome (FXS) and fragile X tremor/ataxia syndrome (FXTAS). We have shown here that the number of G…G/C…C mismatches dictate the secondary structural choice of the sense and antisense strands of fmr1 gene and the corresponding transcripts. Circular dichroism (CD) spectra reveal that CGG sense strand and its transcript favour quadruplex structure due to the intolerance for periodic G…G mismatch in a hairpin/duplex. Further, CD and molecular dynamics simulations show that more than four C…C mismatches cannot be accommodated in an RNA duplex consisting of CCG repeat (antisense transcript), instead, i-motif structure is favored. In contrast, CCG can form hairpin/duplex structure at the DNA (antisense strand) level irrespective of the number of C…C mismatches. Such unusual structures may be responsible for the increased R-loop stability, bidirectional transcription, RNA foci formation and repeat associated non-AUG translation for monopolypeptide aggregates in FXTAS, a mechanism similar to C9ORF72 GGGGCC repeat expansion that causes amyotrophic lateral sclerosis. The results presented here also suggest that G-quadruplex structure observed in fmr1 gene and its transcript can be a potential drug target.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Yogeeshwar Ajjugal and Narendar Kolimi Indian Institute of Technology, Hyderabad at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Modernization of traditional anti-malarial drug artesunate via nanomedicine approach

Students of Shiv Nadar University, Uttar Pradesh, Deepika Kannan, Nisha Yadav,  won the award for research work of Modernization of traditional anti-malarial drug artesunate via nanomedicine approach. They carried their project work under the guidance of Dr. Shailja Singh, Dr. Bimlesh Lochab, Dr. Soumya Pati.

The burden of malaria has been prevailing since ages in India with a death toll of 1.31 million per year. The failure in combating the disease has been attributed to the drug resistance, limited efficacy of the drug or lack of immunogenicity of vaccine antigens against all strains of plasmodium. In our study, we have applied a smart strategy to deliver the drug along with its catalyst (ferrous ion) in a sustainable manner which will help in improving the therapeutic effect of the drug. The novel innovative approach undertaken in the study has showcased the efficiency of surface coated iron nanoparticles as enhancer of the anti-parasitic activity of artesunate in vitro. This further succour the targeted delivery of the drug and the nanoparticle to the parasite’s food vacuole. The site of action being acidic in pH, the particle mediates delivery of the drug and ion in a slow-release manner. Slow dispersion enables a constant mode of action of the drug rather than an outburst. Thus, a continuous source of radical species is released. Since in combination with nanoparticle the drug remains in the active state for a prolong period, the damages occurring to the parasite is extensive as compared to the drug without nanoparticle. Further observation interpreted that in vitro the measure of ROS within drug+nanoparticles treated parasites were elevated as compared to the drug-treated parasites. Additionally, increased ROS exerted increased DNA and protein damage (in terms of carbonylation and alkylation).

Though the mechanism of free iron uptake by the plasmodium is still inconclusive, difficulty in protecting the human population against malaria by using iron nanoparticle is highly debatable. Based on the in vitro studies observation for the first time was deciphered that the surface coated iron nanoparticle alone did not affect the parasite growth. However, the results demonstrated iron nanoparticle together with artesunate depicted reduced parasite load in a dose dependent manner. In vitro and in vivo data indicated the combination exhibited ~5 folds (IC50 value of 0.4nM) decrease in the dosage level as compared to artesunate alone (IC50 value of 2nM). The fabrication of the nanomedicine provides a means to eliminate the parasite load sustainably such that the effect of the drug is prolonged, providing a mode of complete parasite clearance.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Deepika Kannan, Nisha Yadav, Shiv Nadar University, Uttar Pradesh at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Magnetic-field actuated hybrid nanofiber scaffold and apparatus for 4D tissue engineering

Students of Indian Institute of Technology, Roorkee Uday Kumar Sukumar and Vinay Kumar won the award for research work of Magnetic-field actuated hybrid nanofiber scaffold and apparatus for 4D tissue engineering. They carried their project work under the guidance of Dr P. Gopinath.

The present invention provides a hybrid multi-layered nanofibrous scaffold and a four-dimensional dynamic cell culture apparatus. The pre-existing 3D scaffolds in the market does not address the dynamic culture conditions covered in this technology, therefore, they do not represent the in-vivo conditions as closely as the 4D scaffold proposed in this research work. The market of 4D scaffolds is focussed on the area of therapeutics and diagnostics. 4D scaffolds are expected to reduce the need for animal disease models, as they are versatile in accustoming to different culture conditions, and are more relevant for cell culture studies as compared to 3D scaffolds. Furthermore, the scaffold is biocompatible and operates in non-contact mode and it is precisely controlled across all 3- dimensions. The hybrid scaffold apart from providing the extracellular matrix (ECM)-like scaffold, also meticulously simulates the mechanical stress cycles that cells experience under the in-vivo conditions.

For monitoring cells on a real-time basis under microscopes, the apparatus is provided with sufficient headspace over the tissue culture plate for positioning a microscope lens. The circular slot provided at the base of the apparatus perfectly accommodates cell culture plates and also enables easy transmission of light during microscopic observation without any interference of the apparatus body. Cell plasticity, differentiation and cancer metastasis are determined to a large extent by cell adhesion and surface proteins which are effectively recapitulated in this scaffold. The scaffold serves as a realistic and relevant platform for studying the role of cytoskeletal proteins and focal adhesion proteins in various diseases in the fields of cardiology, dermatology, metabolism, gastroenterology, oncology and orthopaedics.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Uday Kumar Sukumar and Vinay Kumar, Indian Institute of Technology, Roorkee at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Yog-I – An affordable insulin pump for Type-1 diabetic patients in resource constrained settings

Students of Indian Institute of Science, Bangalore, Deval Karia, Rohit S. Nambiar won the award for research work of Yog-I – An affordable insulin pump for Type-1 diabetic patients in resource-constrained settings. They carried their project work under the guidance of Dr Manish Arora.

Numerous studies have been extensively documented for the benefits of Continuous Subcutaneous Insulin Infusion (CSII) over Multiple Daily Injections (MDI) for insulin therapy in Type 1 Diabetes Mellitus (T1DM) patients. Despite such overwhelming evidence in support, adoption of CSII is sparse, particularly in resource-constrained settings like India. Apart from the institutional factors, fixed and recurring costs of such a device are often found to be a withholding factor for widespread application. The abstract describes the development of a novel, affordable insulin pump for T1DM patients matching the specifications of a state-of-the-art pump, while significantly bringing down the fabrication cost. Most pumps rely on a lead screw/nut coupled with a geared DC motor to achieve precise micro-motion.

 

 

 

 

 

 

These motors typically make use of micro-gears as a means of speed reduction, which is inherently expensive to manufacture. Consequently, they contribute significantly to the final cost of a pump. In this work, we take an innovative approach to distribute the requisite speed reduction in multiple stages, with an acceptable compromise on the product size. The system is actuated by a nominal DC geared motor and a novel mechanism of converting continuous rotary input to intermittent output. The kinematic chain is feedback-controlled which ensures volumetric accuracy of the delivered fluid. The pump can be wirelessly controlled via a remote. The same wireless channel can be used to connect to a Continuous Glucose Monitoring (CGM) device for subsequent integration with an Artificial Pancreas system. Preliminary accuracy tests showed promising results when compared with commercially available devices.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Deval karia,Rohit S. Nambiar, Indian Institute of Science, Bangalore at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

 

Anti-Pesticide Dermal Gel

Students of Instem, Bangalore, Ketan Thorat and Subhashini Pandey won the award for research work of Anti-Pesticide Dermal Gel. They carried their project work under the guidance of Dr Praveen Kumar Vemula.

Due to lack of resources, spraying pesticide using the hand-held manual device is a norm in Indian agriculture. In the past three years, more than 3000 farmers in India were hospitalized due to an alarming frequency of pesticide exposure which eventually led to a tragic toll of 442 deaths. This severe clinical gap has a massive impact on the health of 263 million farmers and their families in India. Considering the above facts, the study has been conducted to develop a skin-gel that can protect the farmers from the harmful effects of pesticides. The skin-gel constituted with numerous chemical detoxifiers when applied, instantly attacks the pesticide molecule and catalytically cleaves it into smaller, non-harmful components, thereby diminishing the toxic effect of pesticide.

Usually, the skin is exposed to a large amount of pesticide which transdermally enters the body. Over time, these farmers are further exposed to multiple small doses of pesticides during spraying and handling at farms which leads to an accumulated, irreversible health damage resulting to learning difficulties, suffocation, paralysis, muscle weakness, loss of stamina, and in certain cases-death. This impact affects healthcare costs and major socio-economic implications. The distinctive feature of this study is to formulate a skin gel that safeguards the transdermal route undertaken by the detrimental pesticide molecules to enter the human body. The pioneering work of this skin-gel technology lies in the fact that each detoxifier can detoxify multiple pesticide molecules. Therefore on a single application, it offers a 24 hr protection against pesticides

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Ketan Thorat and Subhashini Pandey, Instem, Bangalore at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Development of engineered E.coli for high-throughput drug screening against Malaria and Kala-azar

Student of Jawaharlal Nehru University, Delhi, Preeti Yadav won the award for a Development of engineered E.coli for high-throughput drug screening against Malaria and Kala-azar. She carried her project work under the guidance of Dr. Shailja Singh, Dr. Swati Garg, Dr. Soumya Pati.

Eukaryotic parasites increase the functional diversity of their proteome through a number of post-translational modifications (PTMs), to facilitate their survival and replication. Palmitoylation is one of the important PTM present in eukaryotic cells that modulate protein-protein interactions and plays a major role in several diseases like Cancer, Diabetes, Schizophrenia, Alzheimer’s, Malaria, Leishmaniasis, etc. In malaria parasite, Plasmodium falciparum, 10% proteome have been found to be palmitoylated that plays a crucial role in disease progression and pathogenesis, while in Leishmania donovani, we have reported that 25% of the total proteome gets palmitoylated and is involved in flagellar motility, vesicular trafficking and invasion. Plasmodium falciparum and Leishmania donovani encodes for 12 and 20 Palmitoyl acyl transferases (PATs) respectively that transfer palmitate group to target protein. Being a major contributor of parasite-diversity, palmitoylation has not been explored as a chemotherapeutic target yet due to paucity of high-throughput assays.

Prevalence of drug resistance demands immediate action to search for newer drugs and newer targets. We have developed a novel strategy involving engineered E. coli to study parasite-specific palmitoylation. E.coli is a palmitoylation machinery-null system, but our in-silico study suggested that 110 proteins of E.coli contain sites for palmitoylation. Thus, these E.coli proteins can serve as substrates for parasite-specific PATs expressed in E.coli. Parasite PATs were cloned and expressed in E.coli in the presence of PAT inhibitor and palmitoylation status of E.coli was analysed using Click chemistry. The inhibitor, 2-Bromo-palmitate that we have used here acted both as anti-malarial and anti-leishmanial as deduced by parasite growth-inhibition assay and invasion assay respectively. This is the first ex-vivo study of parasite-specific modifications in E.coli, that could be used as a robust, high-throughput screening tool for anti-protozoan drugs targeting palmitoylation, thus helping in the development of novel anti-parasitic molecules.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Preeti Yadav, Jawaharlal Nehru University, Delhi at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

 

Novel hybrid Technology for Bioseparation

Student of Institute of Chemical Technology, Mumbai Jayeshkumar Sevantilal Mevada won the award for research work of Novel hybrid Technology for Bioseparation. They carried their project work under the guidance of  Prof. Aniruddha B. Pandit.

In Current era, the unaffordability of medicine to rural peoples and pollution of the river are the big issues for the developing countries. A biological approach is an alternative way for the replacement of hazardous chemical processes responsible for water pollution, but the cost is the primary concern for its applicability. The microbial cell is the factory of various biological products located intracellularly or extracellularly. 

Conventional method (High-pressure homogenizer) causes the complete cell disruption which results in the release of all the contaminating materials with the target product of interest. This contaminating materials restrict further purification which leads to problems such as membrane fouling, higher processing times, reduced life of chromatographic column, increase in the steps of purification (10-13 steps) and higher cost of purification (70 to 80 % cost of total production cost).

We have developed novel hybrid technology where controlled cavitation using the hydrodynamic cavitating device was used for the selective recovery of intracellular biomolecules at microbial cell disruption stage (with a pretreatment regimen of acidic as well as alkaline conditions). Synchronizing of pretreatment and cavitating conditions result in selective recovery of biomoleculesfrom the cytoplasmic and periplasmic location of cells with minimal contaminating materials. The developed technology is believed to be novel and a breakthrough in the field of bioseparation. The expensive multi-bioseparation steps can be avoided because of the selective recovery of biomolecules at the initial stage. The uniqueness of this invention when compared with the existing technologies augment its characteristics in selectiveness, energy efficiency, easily scalable, reduced number of steps (from 10-13 to 3-5), low overall cost (3-4 times), 4-5-time reusability of immobilized product. Apart from the aforementioned qualities, the cost reduction by the developed technology can be considered as the big initiative step toward the greener processes and affordable cost biotherapeutics.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Jayeshkumar Sevantilal Mevada, Institute of Chemical Technology, Mumbai at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Bioelectric toilet: A novel approach for treatment of human waste and generating onsite electricity for lighting toilets

Students of Indian Institute of Technology Kharagpur, Indrasis Das, Dipak A. Jadhav won the award for research work of Bioelectric toilet: A novel approach for treatment of human waste and generating onsite electricity for lighting toilets. They carried their project work under guidance of  Dr. Makarand Madhao Ghangrekar.

Improper sanitation facilities in India are causing serious health hazards and lead to water contamination. Different types of onsite sanitation practices adopted in rural areas viz. aqua privy, pit privy, bore hole latrine, dug well latrine, septic tank etc. Among them, septic tank is most commonly used sanitation facilities in rural areas. But this can only remove chemical oxygen demand (COD) of about 30 to 40% from sewage and remaining organic matter along with pathogenic microorganisms left to the environment to pollute the water bodies. The concept of ‘Bioelectric Toilet’ is based on Microbial fuel cell (MFC) technology which gives improved treatment to black water and sludge settled in the septic tank and generates bioelectricity. Odour problems associated with the septic tank minimizes due to anaerobic oxidation of ammonia and sulfide to nitrogen and elemental sulphur, respectively. Recently, a field scale 1500 L capacity multi-chamber multiple electrodes type (5 air cathode MFC and 1 aqueous cathode MFC) bioelectric toilet installed and put under operation in IIT Kharagpur campus since last six months. More than 95 percent COD (Chemical oxygen demand) removal efficiency was achieved and sustainable electrical energy production observed from this reactor which can illuminate toilet and toilet premises at night. Hypochlorite dosing is done as catholyte in the final cathode chamber of aqueous cathode MFC which reduces pathogenic contamination. Treated water can be reused and recycled for flushing purpose which decreases the fresh water consumption and makes it suitable for water scarcity areas.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Indrasis Das, Dipak A. Jadhav , Indian Institute of Technology Kharagpur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

NOWAH (No Waste at Household) Technology – A novel, sustainable, smart and complete treatment technology for both faecal sludge and organic waste management

Students of Indian Institute of Technology Madras , Anu Rachel Thomas, Kaviyarasan R, Arya V, Praveen Rosario A won the award for research work of NOWAH (No Waste at Household) Technology – A novel, sustainable, smart and complete treatment technology for both faecal sludge and organic waste management. They carried their project work under guidance of  Prof. Ligy Philip.

Providing environmentally safe sanitation to the world’s second most populated nation is a challenging task. In India, the total sanitation coverage is 50% and in that only 12% have a piped sewerage connection. Majority of the households depends mainly on on-site wastewater treatment systems like septic tanks as their sole sanitation. Untreated septage disposal creates environmental degradation which mainly includes potential greenhouse gas emissions, percolation of emerging contaminants triggering water body contamination and also causes serious health threats as it contains millions of pathogens. In this context, our team has developed “NOWAH (No Waste at Household)” Technology – A novel, sustainable, smart and complete treatment technology for both faecal sludge and organic waste management. In this treatment system, fecal sludge containing both liquid and solid parts is separated initially at the separating chamber. Further the liquid effluent is biologically treated in an attached bioreactor (ABR) and the treated water can then be recycled for gardening. The dewatered solids will be conveyed to a composting chamber, where it will be cocomposted with organic waste from household. The final compost can then be used as a plant fertilizer. All these units are linked to one another and are underground concrete structures. The proper functioning of this system can be easily made using a cycle with gear mechanism fixed above ground. Thus, the proposed “NOWAH” technology aims at treating the faecal matter at the source where it is generated together with resource recovery in a sustainable and hygienic way. It is a closed loop system with zero power requirement. NOWAH technology can be easily adopted in any household and can even be scaled up for small communities.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Anu Rachel Thomas, Kaviyarasan R, Arya V, Praveen Rosario A , Indian Institute of Technology Madras at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

On Board Diagnostic Data Analysis System – OBDAS

Students of University of Petroleum and Energy Studies, Dehradun, Archit Agarwal won the award for research work of On Board Diagnostic Data Analysis System – OBDAS. He carried his project work under guidance of  Dr. Rajesh Singh, Anita Gehlot.

OBDAS is a complete Automotive Electronics Solution that can be plug-in to any vehicle irrespective of the manufacture. Now through OBDAS vehicle’s valuable information is on cloud that is accessible to different communities that can make value out of it. It is capable fetch real time data about car with more than 200 parameters through more than 25 ECUS. It process data with developed algorithms and convert into the valuable information.

 Then analyzed and upload information to the secure cloud server of the dedicated end-user’s vehicle. OBDAS is divided into two parts one is OBDAS BlackBox under the steering wheel which fetch, process and upload vehicle information to the cloud server and other is OBDAS Notifier over the dashboard which notifies in real time about the car performance to the end-users OBDAS making values to different communities Segment 1 Car owner · End user alerted in real Time about their car Diagnostic and overall performance through OBDAS Notifier · Notifies emergency services as soon as accident is detected with more than 95% accuracy based upon airbags and other parameters Segment 2 Automobiles companies · These companies can analyze and improve their manufactured car better than before by tracking their customer performance through OBDAS · They can now provide real time service to their customer about car the maintenance · OBDAS give the availability for customization with respect to parameters. Auto-Insurance Companies · Now, These companies can get telematics about history of their customer car · Capable to have accurate decision with respect to insurance policies based upon their customer car history · Can improve their business financially.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Archit Agarwal, University of Petroleum and Energy Studies, Dehradun at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

SIT: Smell Your Health

Students of Shri Vishnu Engineering College for Women, Andhra Pradesh, Srilekha Pilla, Jyothi Chinta, Dr. M. Mohan Varma won the award for research work of SIT: Smell Your Health. They carried their project work under guidance of  Dr. Pushpa Kotipalli.

A neurological disorder is a disease that involves the brain and nervous system. There are many types of neurological disorders, including Alzheimer’s disease, epilepsy, multiple sclerosis, Parkinson’s disease, and migraines. The World Health Organization reports that there are millions of people around the world suffer from neurological disorders. Around 24 million people suffer from Alzheimer’s disease and 326 million people suffer from migraines. Similarly, there are around 70 out of 10,000 people suffering with Parkinson’s disease in India. People met with accidents may get neurological disorders which may not be identified immediately. Detection in the early stage is very important to stop the progress of all these neurological disorders. Olfactory dysfunction is the early stage symptom to many of the neurological disorders. Here olfactory dysfunction refers to partial or complete smell loss. If a person notices symptoms like frequent headaches, blurry vision, fatigue, numbness in the legs or arms, physical imbalance, muscle weakness, slurred speech or tremors, he needs to take Smell Identification Test (SIT). If the person fails in the SIT, he should seek immediate help of professional medical practitioner. Existing SITs are not user friendly. We propose user friendly SIT. Mechanical setup of the tester is designed in such a way that oil bottles used with SIT can be accessed easily. The person under test has to identify the smell of the scent from the oil bottle. Answer booklet is provided in their preferred language. Depending on the number of correct answers, the person’s smell identification capability can be assessed which in turn helps in early detection of neurological disorders. Our current innovation is user friendly in terms of operation, language, size, portability, and cost.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Srilekha Pilla, Jyothi Chinta, Dr. M. Mohan Varma , Shri Vishnu Engineering College for Women, Andhra Pradesh at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Smartphone based portable low-cost continuous wave Doppler Ultrasound system

Students of Indian Institute of Technology Kharagpur, Biswabandhu Jana, Rakesh Biswas, Pallab Nath won the award for research work of Smartphone based portable low-cost continuous wave Doppler Ultrasound system. They carried their project work under guidance of  Prof. Swapna Banerjee, Dr. Goutam Saha. 

The Peripheral arterial disease is an important cause of morbidity and affected almost 202 million people worldwide in 2010. A high end medical diagnostic system in rural healthcare units is not available due to its high cost. So, an attempt has been made to design a portable, low cost, smartphone based, continuous wave Doppler Ultrasound System for common people. The designed Ultrasound system consists of three major blocks, viz., Analog Front End (AFE), Signal Processing Block (SPB), and User Interface Block (UIB). In AFE, a pencil probe of 8 MHz is positioned on the artery to receive the backscattered signal and a tuned RF amplifier followed by an envelope detector is used to extract the Doppler shifted signal. The de-modulated signal is digitized for sending to the SBP module. The SBP is a Microblaze soft core processor based embedded system where processing is performed in an FPGA. The UIB displays spectrogram in real time and transfers to mobile through Bluetooth. Next, a smartphone application has been developed for further analysis. Android application removes the noise from the spectrogram and extracts clinically important blood flow features. A machine learning algorithm has been implemented in the smartphone for identifying the normal and abnormal condition. UNIQUE FEATURES – Diagnosis of arterial diseases by assessing the inconsistent blood flow in the peripheral arteries. – Detection of the exact zone of aortic obstruction. – Determine the normal and abnormal condition in an automated way. – The blood flow image can be sent to the doctors. – Abnormalities in an arterial system can be diagnosed by changing only transducer probe. – Detect Korotkoff sound for blood pressure measurement.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Biswabandhu Jana, Rakesh Biswas, Pallab Nath , Indian Institute of Technology Kharagpur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

An indigenous technology for development of cost-effective and energy-efficient engine intake air filters

Students of Indian Institute of Technology Delhi, Ajay Kumar Maddineni won the award for research work of An indigenous technology for development of cost-effective and energy-efficient engine intake air filters. He carried their project work under guidance of  Dr. Dipayan Das.

In automotives, the packing space in vehicular under-hood is shrinking day-by-day at a faster rate with the evolving engine technology. This limits the filtration area available for engine air filters, which causes an increase in local velocity of the airborne particles approaching to the filter media.

 As a result, the particles acquire higher kinetic energy that facilitates them to bounce back from filter surface, re-entrain into air stream, and finally penetrate through the filter media. This ultimately results in higher particle penetration and lower engine life. In the current innovation, an indegeneous and cost-effective solution is provided to the above-mentioned problems associated with the engine intake air filters. A compact engine intake air filter system is designed for motorcycles and the same is analyzed for air flow and particle filtration behaviors. The air filter system consists of a fibrous filter media, which, upon optimal impingement of viscous liquid, exhibits enhanced filtration performance by inhibiting particle bounce and re-entrainment. Further, because of the presence of the viscous films, a large number of dust particles get accumulated onto the air filters. Also, the dust particles are deposited quite uniformly onto the surface of chemically-treated air filters, unlike the untreated air filters where the dust particles form dendritic structures. As a result, the pressure-drop and service life of chemically-treated air filters are found to be superior to untreated ones. Consequently, the air filters developed in this work are likely to offer increased service life by 1.5-1.8 times, decreased fuel consumption by 20 litre and reduced CO2 emission by 50 kg per motorcycle for a ride of 12000 km before replacement of the filters.

 

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Ajay Kumar Maddineni , Indian Institute of Technology Delhi at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Detection of hydrocarbons by Laser Assisted Paper Spray Ionization Mass Spectrometry (LAPSI MS)

Students of Indian Institute of Technology Madras, Pallab Basuri, Depanjan Sarkar won the award for research work of Detection of hydrocarbons by Laser Assisted Paper Spray Ionization Mass Spectrometry(LAPSI MS). They carried their project work under guidance of  Prof. Thalappil Pradeep.

We have introduced a new ambient ionization technique named ‘Laser Assisted Paper Spray Ionization Mass Spectrometry’ (LAPSI MS). In LAPSI MS, a 532 nm ≤10 mW pen torch laser pointer was shown to a triangular paper along with high voltage to enhance the paper spray ionization. The analyte solution was continuously pushed through a fused silica capillary, using a syringe pump, at a preferred infusion rate. LAPSI MS promises enhanced ionization with high signal intensity of polycyclic aromatic hydrocarbons (PAHs), which are normally not ionizable with other mass spectrometric techniques. LAPSI MS works both in positive and negative modes of ionization. A clear enhancement of signal intensity was visualized in the total ion chromatogram for an analyte in presence of the laser. 

 

We speculate that the mechanism of ionization is field assisted photoionization. The field-induced distortion of the potential well can be large in paper spray as the fibers constituting the paper are separated at tens of nanometers apart and consequently the analyte molecules are subjected to very large electric fields. LAPSI MS can be used for monitoring in situ photo-assisted reactions like, the decarboxylation of mercaptobenzoic acid in presence of gold and silver nanoparticles and dehydrogenation reaction of 2,3-dihydro-1Hisoindole, for example. As an application we have shown that the paraffin oil which is usually non ionizable by paper spray or by electrospray ionization can be efficiently detected using this technique. As a real life application, such impurities like mineral oils were detected in commercially available coconut oil.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Pallab Basuri, Depanjan Sarkar, Indian Institute of Technology Madras at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Augmentative Rehabilitation of SCI and Stroke Patients

Student of CSIR, Chandigarh, Kashif Islam Khan Sherwani won the award for research work of Augmentative Rehabilitation of SCI and Stroke Patients. She carried her project work under guidance of Dr. Neelesh Kumar.

According to World Health Organisation, 15 percent of world’s population have some sort of disability. But only 7 percent of the world’s population has access to physical medicine and rehabilitation. Lack of quality physiotherapists and awareness about specialized rehabilitation care makes this situation worse and that too is limited to tier 2 cities in India. Spinal Cord Injury, Cerebral Palsy, Parkinson’s disease are few chronic diseases that require continuous rehabilitation, but the patients are not able to visit rehabilitation clinic regularly because of distance and/or cost issues. Because of this reason patients’ start losing interest. If still, they try to visit the therapist, it becomes very monotonous of doing same traditional exercises and does not get any motivation and feedback to track their daily progress.The solution for the above problem is the augmentative rehabilitation that includes virtual reality therapy system that stimulates training of neuromotor movements, houses a wide array of abilities, delivers a simple way for physicians to track usage, and could be used at home and primary health centers. VR technologies offer new space for human exploration, understanding, and support by providing patients a safe environment in which they can interact and develop a goal and taskoriented activities within functional-virtual environments, especially when they find themselves in situations of cognitive, behavioural or motor disabilities. The solutions built from these technologies reduce patient’s limitations of activity and participation by promoting the recovery of functional motor abilities stemming the emerging philosophy of rehabilitation.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Kashif Islam Khan Sherwani , CSIR, Chandigarh at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

TULO – An Automated Mandibular Advancement Device for the Treatment of Obstructive Sleep Apnea

Student of Indian Institute of Technology Kanpur, Vimal C won the award for research work of TULO – An Automated Mandibular Advancement Device for the Treatment of Obstructive Sleep Apnea. He carried her project work under guidance of Prof. Dr. J. Ramkumar.

Obstructive sleep apnea is a sleeping disorder that affects about five percent of adults. Sleep apnea is a condition in which the airway in your throat collapses when you sleep, so the muscles relax. If this collapse is constant, it causes apnea or simply said absence of breath. If the collapse is not constant, usually causes snoring. The long term consequences of having obstructive sleep apnea are high blood pressure, sleepiness, headaches and risk of heart attack or stroke. Mandibular advancement devices have mouth guard that is fitted to both top and bottom teeth and joined together in a way that bottom teeth are in front of the top teeth. Pushing the bottom jaw forward opens up and supports the airway, so there is less chance to collapse. Mandibular advancement devices are the oral appliance used to treat snoring and obstructive sleep apnea. These devices protrude the mandible and induce changes in the anterior position of the tongue, soft palate, lateral pharyngeal walls, and mandible, resulting in improved airway patency. Evidence suggests that MAD improves snoring and OSA. Extent of advancement in MAD enhance efficacy in reducing upper airway obstruction events but it also increases temporomandibular joint pain, myofascial pain, occlusal changes and anxiety and stress of the patient. Usage of a MAD device however requires some precision adjustment and frequent visit with the physician thus induces a lot of ambiguity to the user. Hence we have developed an automated MAD device in two specific advancement platforms. One is a time dependent mandibular advancement while the other is advancement of the mandible with respect to oxygen desaturation levels in the body through a wearable band.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Vimal C, Indian Institute of Technology Kanpur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Katha-Exploration of narrative approach in furniture design

Students of Indian Institute of Technology Kanpur , Ritika Singh won the award for research work of Katha-Exploration of narrative approach in furniture design. She carried her project work under guidance of Dr. Koumudi Patil.

Katha aims to foster creative problem solving, causal thinking and articulate communication skills in children through a narrative playlearning aid. This play-aid is a responsible and sustainable product, designed for manufacturing by craftspeople (Banarasi wooden toymakers) in an additional effort to integrate the neglected craft sector with a contemporary educational need for creative pedagogies. Katha attempts to link the lacunae in our education system with the needs of our craft sector. Therefore, the board game has been designed for manufacturability in the craft sector and not through a machine. The turned characters as well as the wooden board and painted motifs can be made best by hand. The size of the pegs, threading, and form of characters have been decided based on the turning device used by the Banarasi wooden toymakers. Thus, this is design for craft manufacturability. The idea is not to mass produce but create limited editions of high value. Katha consists of multiple narrative trajectories that can be constructed into myriad stories that encourage the child’s critical abilities to juxtapose the causal connections into a coherent whole. It encourages the lateral thinking hat of the child and emboldens him to create his own path rather than follow a prefixed trajectory. It also playfully introduces the child to our cultural heritage hidden deep in our ethics.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Ritika Singh , Indian Institute of Technology Kanpur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Loco pilot vision enhancement system: TRINETRA (Third Eye) for Indian Railways

Students of Indian Institute of Technology BHU, Varanasi, Anand Kumar K. S., Gurupadappa Motagi, Ravindran R won the award for research work of Loco pilot vision enhancement system: TRINETRA (Third Eye) for Indian Railways. She carried her project work under guidance of Prof. (Dr.) R. K. Saket.

Indian Railway provides the most important mode of public transport in India. It is the most commonly used and cost effective long distance transport system of the country. Indian Railways is also helping Indian economy in many ways like by providing fast and reliable transport medium for various needy articles across the country. The railways are suffering revenue losses due to cancellation or late running of passenger trains as a result of foggy weather conditions especially in the northern India fog-prone regions. In last five years the Indian railways has lost in access of Indian rupees 1.5 lakh crores due to cancellation of trains, and delay in running trains. Considering its importance, this project work TRINETRA – the third eye to prevent railway accidents in India, has been researched and dedicated to Bharat Ratna Madan Mohan Malaviya Chair at IIT-BHU for railway research. It marks the centenary celebrations of Banaras Hindu University. TRINETRA is expanded as “Technological Research and Invention for National Empowerment of Trains to Reduce Accidents”. In Hindi, the word TRINETRA means ‘Third Eye’. Equipped with zoom able visual and thermal sensor TRINETRA will be fixed on the front portion of the engine (Loco-motive). It will effectively catch a long range view of the track and present it live on a mini screen (smart phone) fixed at the loco pilot’s cabin. They can see the long range of the track on screen. The sensor and screen will be interfaced through OTG or Wi-Fi. TRINETRA an indigenous camera system is an outcome of our efforts to address the current operational visibility issues faced by the loco pilots during odd weather conditions especially fog & rain.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Anand Kumar K. S., Gurupadappa Motagi, Ravindran R , Indian Institute of Technology BHU, Varanasi at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Cerium Impregnated Activated Carbon Composite as a Filtering Material for Fluoride Removal from Groundwater

Students of Indian Institute of Technology Patna, Mahipal, Hasan Ahmed Faisal won the award for research work of Cerium Impregnated Activated Carbon Composite as a Filtering Material for Fluoride Removal from Groundwater. They carried her project work under guidance of Dr. Trishikhi Raychoudhury.

Groundwater Contamination with fluoride (F-) is a major concern due to its chronic behavior on human health. In India, specific region of Rajasthan, Gujarat, Telangana and Andhra Pradesh are severely affected by Fcontamination. To address this issue, there is a need to investigate for cost effective, efficient and environmental friendly technology focused primarily on F-removal from groundwater.There are only a few studies available that focus on removal of F- from natural groundwater.

 Therefore, to address this issue, several groundwater samples were collected from the Nagaur district of Rajasthan and with an objective to remove F- from the groundwater samples using a novel composite (AC-Ce). In this study, cerium metal was impregnated within granular activated carbon(AC-Ce) to increase its adsorption capacity. The study suggests impregnation of Ce in AC has enhanced the fluoride sorption efficiency significantly (0.27 mg/g to 2.9 mg/g). Sorption of F- and along with ion-exchange between nitrate and F- are attributed to high F- removal by the ACCe composite.The performance of the composite within a 1-D fixed bed column was studied to investigate the suitability of applying the composite in a filter. Effects of co-ions are also evaluated on fluoride removal by the composite. The result suggests, AC-Ce composite in fixed bed filter media can treat up to 722 ml of 10 mg/l Fcontaminated water. However, performance of composite reduces significantly in natural groundwater. This is due to presence of phosphate and bicarbonate ions competing with F- for active sites on the composite. Suitable pretreatment method should be adopted for addressing this problem.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Mahipal, Hasan Ahmed Faisal, Indian Institute of Technology Patna at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Design and Development of Intelligent and Robust Grid Integrated Solar PV System with Improved Power Quality for Roof Top Applications Especially For Abnormal Indian Distribution Feeder

Students of Indian Institute of Technology Delhi, Amresh Kumar Singh, Ikhlaq Hussain won the award for research work of Design and Development of Intelligent and Robust Grid Integrated Solar PV System with Improved Power Quality for Roof Top Applications Especially For Abnormal Indian Distribution Feeder. They carried her project work under guidance of Prof. Bhim Singh.

This work deals with a novel, intelligent and robust control approach for a three phase grid connected solar PV (Photovoltaic) system, which is based on FZA-NLMF (Fast Zero AttractingNormalized Least Mean Fourth) algorithm and few other robust control techniques. Simultaneously, improvement of traditional maximum power point technique (MPPT) is done here, which enhance the tracking performance of conventional MPPT approach. Moreover, this investigation has done for both single stage as well as double stage solar PV system interfaced with local distribution feeder. These control algorithms achieve the objective of mitigation of power quality issues such as harmonics reduction and power factor correction together with extraction of peak power generated by the PV array. The system uses a PV array, a VSC (Voltage Source Converter), linear and nonlinear loads. Here, VSC is connected to a PV array to transfer the active power to the three phase load and the grid. The dependency on tuning of proportionalintegral (PI) controller is reduced because of feedforward term of the PV power. Due to this, the system dynamic response is improved, which makes the system quite robust. The system goals are to mitigate power quality problems and to provide current conditioning while operating in coherence with a weak distribution grid like abnormal Indian distribution feeder, which has poor quality of power, in terms of voltage distortions with imbalances. MATLAB/ Simulink is used to develop the model of the proposed system. The validation of proposed control is done at varying linear and nonlinear loads and under different environmental conditions on a prototype developed in the laboratory.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to  Amresh Kumar Singh, Ikhlaq Hussain, Indian Institute of Technology Delhi at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Rapid Cervical Cancer Detection using Neuromorphic Hardware

Students of Indian Institute of Technology Delhi, Narayani Bhatia, Shridu Verma won the award for research work of Rapid Cervical Cancer Detection using Neuromorphic Hardware. She carried her project work under guidance of Dr. Manan Suri.

In a vast country like India, trained cytologists are constrained by paucity of time and outreach and manual screening of slides leads to slow detection of disease. This is inadequate, because overburdening of human resources leads to dangerously inaccurate diagnosis, and is not time and cost effective. Our solution is an intelligent cervical cancer diagnostic support system which is a first-in-the-series of experiments to follow. Our aim is to develop low-cost, fast and powerefficient healthcare diagnostic techniques so that no disease goes undetected. We train our neuromorphic hardware solution, which is inspired by the parallelism of the brain to mimic brain-like functionality, on existing datasets of classified slide images and use a machine-learning algorithm implemented on hardware for classification. In a scenario where 99% of the solutions are software-centric, consuming huge amounts of power and employing cloud based services, our custom hardware solution is based on true artificial intelligence resulting in drastic reductions in screening times, enhanced decision-making ability and lower operational costs. It is independent of the magnification at which the pap smear images may be viewed, and is invariant to staining variations that may arise due to laboratory testing procedures in medical labs.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Narayani Bhatia, Shridu Verma, Indian Institute of Technology Delhi at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Ionic movement based desalinator

Students of Pondicherry University , L. R. Ravindranath, S Abilash Varan, M. Logesh, S. Arvindh won the award for developing a prototype of Ionic movement based desalinator. They carried their project work under guidance of  Dr. S. Anbumalar.

Nowadays, mostly coastal areas are in the shortage of drinking water. The areas up to 10 kms from the sea shore are affected by the sea water intrusion and getting high saline groundwater.

This is the major issue in our nation in the supply of drinking water to the people and the inability to supply water to the process industries. This leads to the public health issues, damage of economic development etc..There is an technology called reverse osmosis to reduce salinity, this technology is at the high cost of installation of equipment and RO membrane filters. The yield is also very low. In our proposed method, the filter membrane is replaced by electric polarized electrodes. The principle involved in this proposed system is electrolytic ionic moment towards the opposite charges of the electrodes.The working concept of the system is the water flows, as the water fed into system through a pipe line which is split into two directions, upward and downward flow. The salts coming from feed water flow are diverted into downward flow using the concept of electrolytic ionic movement to the opposite charges of the electrode, which are fixed in downward water flow pipeline part. The downward flow water with ions of salts is drained as reject by utilizing the gravitational force. The upward flow left free from the ions of the salts, this outlet is collected as product. Link: https://www.youtube.c om/watch?v=nsigKZlTpOY | https://www.youtube.c om/watch?v=6moDT6t zccw

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to L. R. Ravindranath, S Abilash Varan, M. Logesh, S. Arvindh , Pondicherry University at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

WhiteCane: A Virtual Assistant for the Visually Impaired

Students of Indian Institute of Technology Kharagpur, Barnopriyo Barua, Kaustubh Mani, Divyansh Gupta won the award for research work of WhiteCane: A Virtual Assistant for the Visually Impaired

We are using various artificial intelligence techniques to simulate a digital assistant that uses the smartphone camera to help visually challenged users in various day to day tasks. The app will take a spoken query as an input from the user.

This query will be converted from speech to text and will then be categorized into one of the many functions like Screen Description, Currency Recognition, OCR, Facial Recognition, Visual Question Answering, Object Localization etc. using the latest state-of-the-art Computer Vision and Natural Language Understanding techniques. This query, along with an image captured by the camera will be passed as an input to the appropriate computer vision model based on the intent predicted in the previous step. The result will then be spoken back to the user by our application, by using android’s text-to-speech functionality. Until now, assistive technologies in this field were usually in the form of standalone hardware devices, which turned out to be prohibitively expensive for most users. The advent of cheap smartphones allows us to use the camera to help users in day to day tasks like currency recognition, face identification, reading, etc. all through an easy to use voice based interface.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Barnopriyo Barua, Kaustubh Mani, Divyansh Gupta , Indian Institute of Technology Kharagpur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Open Source Augmented Reality Wearable Smart Assist Device for Blind

Student of University of Toronto , Sarang Nerkar, Ambarish Gurjar won the award for research work of Open Source Augmented Reality Wearable Smart Assist Device for Blind. They carried their project work under guidance of Dr. Steve Mann.

We present an open source augmented reality wearable device that provides the ability of smart vision to the blind. The device uses facial and object recognition for a smart analysis of the space around the blind person. It uses depth sensing to find out the distances between the user and detected people and objects. Text to speech techniques are used to inform the blind person about the smart analysis of the space around them. The device uses gesture recognition to trigger the audio output in order to prevent the device from being a distraction rather than an aid. The device is implemented as an open source platform to encourage open innovation in the field of assistive technologies.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Sarang Nerkar, Ambarish Gurjar, University of Toronto at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

A Computational Alternative to Analyze and Understand Ebola Virus Pathogenesis in Human

Students of Indian Institute of Technology Kharagpur, Abantika Pal, Anupam Banerjee won the award for research work of A Computational Alternative to Analyze and Understand Ebola Virus Pathogenesis in Human. They carried their project work under guidance of Dr. Pralay Mitra.

Zaire ebolavirus (EBOV), one of the most pathogenic species of Ebolavirus, is a significant threat to the human community according to the World Health Organization Ebola Situation Report. Several efforts have been made to design vaccines and therapeutic drugs without much success owing to the limited binding site residue information of human protein interacting with the viral protein (VP) molecules. Such limitations stem largely from the highly infectious nature of the virus that requires specialized personnel and bio-safety Level 4 laboratories to perform wet lab experiments. Although critical interactions involving the VPs and the human proteins responsible for innate/adaptive immune responses are discovered, specific binding information between such pairs is still unknown in most cases. Therefore, we proposed a protein interaction and protein design based computational alternative to identify critical residues crucial for the human protein-VP interactions. The computational framework used an existing protein design algorithm ensuring evolutionarily and energetically favorable mutations on interface residues of a participating protein in a protein complex. The VP24-KPNA5 (karyopherin alpha proteins 5) interaction is an experimentally well-studied phenomenon concerning EBOV pathogenesis and was therefore chosen to establish the efficacy of the proposed method. The critical residues identified in the VP24-KPNA5 interface by the proposed method were in excellent agreement with the previously reported experimental findings. Additionally, the mutations of the critical residues affected the overall stability of the complex because of a sharp decrease in both the number of hydrogen bonds and possible charge-charge interactions. Therefore, we propose that the computational framework could be extended to destabilize similar host-pathogen (like Human proteins interacting with Ebola:VP35) interactions, the critical interacting residues of which are to date unexplored.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Abantika Pal, Anupam Banerjee, Indian Institute of Technology Kharagpur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Brain wave nerve excitation for physically disabled

Students of SCMS – School of Enginnering and Technology, Kerala, Sarath S, Shilpa M Biju, Shilpa P Prasad, Midhun Raj, Sachin S, Nandha Kiran, Hridhya Jolly K won the award for research work of Brain wave nerve excitation for physically disabled. They carried their project work under guidance of Dr Sunil Jacob.

Paralysis is a problem that has been plaguing the general population ever since mankind has evolved. It is a disheartening sight to see the plight of these differently abled people not being able to bring in as much productivity as the normal population out in the real world. Of the total world population, over 29% suffer from paralyzes due to stroke or some other reasons.

Paralysed person has a clot in the brain cells that blocks the signal transmission from brain to muscle. To solve this problem we introduce the Brain to Muscle Interface for Paralyzed (BMIP) technique. The BMIP will act as a direct interface between brain and muscle by bypassing the clotting between them. This interface helps brain to control the muscle movements according to his thinking and concentration. The wearable glove that is attached to the controlling person contains the EMG electrodes which tap the excitation produced due to the corresponding movement and it is then converted into an EMG signal .We use TENS (Transcutaneous Electrical Nerve Stimulation) device that provides electrical stimulation for excitation. The headset contains 16 EEG electrodes in total (14 live electrodes & 2 reference electrodes). These electrodes are placed in contact to the necessary nerve excitation points in head. Arduino is used as an interface between the spiker shield, TENS device and the hand gloves. The person controls the movements by thought and it’s an efficient way of helping the paralyzed to do their real time activities. Link: https://youtu.be/t7iYi822lGM

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Sarath S, Shilpa M Biju, Shilpa P Prasad, Midhun Raj, Sachin S, Nandha Kiran, Hridhya Jolly K, SCMS – School of Enginnering and Technology, Kerala at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Buzzing Band For Hearing and Speech Impaired

Student of Shri Vishnu Engineering College for Women, Andhra Pradesh , Saka Naveena, Panchakarla Sevya Naga Priyanka, Khande Dhana Lakshmi , Murikipudi Bindu Madhaviwon the award for research work of Buzzing Band For Hearing and Speech Impaired. They carried their project work under guidance of Prof. Ravuri Viswanadham, Prof. K. Padma Vasai .

Communication is part and parcel in every man’s day to day life. But it causes several difficulties for a person who is hearing impaired or speech impaired. Even though sign language replaces general talks for them, it fails to draw the attention of the person who is distant from the speaker. This situation causes lack of interaction among the hearing impaired students and the teacher. To overcome the problem faced by students in classroom and enable him to engage with teacher or with distant student a device that supports mass communication is needed. So to suit this requirement, the proposed solution is a device called “BUZZING BAND”. The key feature of this device is to provide one to many communications (between teacher and all students in class) in addition to one to one communication”. In order to achieve the above said communications RF Technology is preferred. Communication from one device to another is easily achieved by using RF technology. The input to the buzzing band is given with the help of a button. The button is connected to the Arduino nano to which an RF transmitter is interfaced. On the receiver’s side there will be an RF receiver which is interfaced with arduino along with a single digit display and a micro vibrator motor. The future innovation uses programming techniques so that signal is sent to various transceivers with a small time delay between each transmission to a single transceiver.

Link: https://youtu.be/jzYk xaMv5xU

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Saka Naveena, Panchakarla Sevya Naga Priyanka, Khande Dhana Lakshmi , Murikipudi Bindu Madhavi, Shri Vishnu Engineering College for Women, Andhra Pradesh at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Development of Smart Wearable Body Warmers Using Graphene Coated Conductive Fabrics

Student of Indian Institute of Science, Bangalore, Nagarjuna Neella, Vaishakh Kedambaimoole won the award for research work of Development of Smart Wearable Body Warmers Using Graphene Coated Conductive Fabrics . She carried her project work under guidance of Prof. K. Rajanna, Prof. M. M. Nayak, Prof. N. S. Dinesh.

Body warmers are generally used to combat cold weather conditions across the globe. Also, they find use in biomedical i.e. electrotherapy treatments, medical blankets for patients to maintain their body temperatures and military worn jackets for soldiers in the defense forces. Moreover, some of the flexible beds employ air cushion which serves as good heat insulator to retain heat but they do not function as body warmer. Additionally, blankets/jackets made up of pure woolens/pashmina from cashmere, caprinae family animal’s fiber may prove to be good body warmer, but quite expensive and hence not affordable for middle class person/common man. Also, no control of warming is available with such garments. Warmers presently available in the market consists of fine wires/films made of metal alloys, ITO and Ga doped Zinc Oxide woven to form high resistances and consumes higher power than proposed RGO. Today’s rapid growth and progress of work in the area of wearable miniaturized electronic devices using nanoscience and engineering concepts have led to the new generation of device technology. Nanomaterials used in elements designed for creating flexible electronics/electrical and fabrics/garments due to their unique properties i.e. large SA/V and dimensionality. Commercial heaters have disadvantages: complicated fabrication and monotonous which leads to special machinery, opacity, heavy and rigidity, intolerance to acid/base, fragile, lower heating efficiency and also bulky, expensive, limited flexibility. So, looking for innovative devices with effective body warming functionality, compatible/flexibility, lower energy consumption & manufacturing costs. Presently developed/invented RGO based cloth fabrication is straight forward either by dipping/pouring solution onto the cloth and curing it suitably. Therefore, our aim is to overcome the above-mentioned drawbacks, wherein the invention provides heating device formed into required shapes, corrosion free, flexible and biocompatible.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Nagarjuna Neella, Vaishakh Kedambaimoole, Indian Institute of Science, Bangalore at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Nano-biosensor And Methods For Detecting Potassium Ion Concentration

Students of Junagadh Agricultural University, Junagadh, Jaymin Kanubhai Jadav, Khyati Jagdish Rathod won the award for research work of Nano-biosensor And Methods For Detecting Potassium Ion Concentration. They carried their project work under guidance of Dr. B. A. Golakiya.

The invention’s outcome will help in determination of potassium deficiency from the standing crop even if the plant is not showing any visible deficiency symptoms. Potassium deficiency levels can be determined at any stage and which will help to prevent its further progress. If on determination, the plant potassium content, is found close to the threshold deficit level or deficient; potash fertilizer which is a readily available form of potassium can be applied to the field crops to recover them from the deficiency and prevent the overall yield losses. 

The invention belongs to electrochemical analysis of activity of ions in sample via a potentiometric sensor. This makes it a field portable and a unique class of biosensors that may be very useful in agricultural fields. The sensor is based upon screen printable technology, where a screen printed electrochemical cell is modified using a biomimetic component say; valinomycin- an antibiotic, one of the most potent potassium (k+) ion carrier to function as ion selective electrode. For measuring ion activity in the mentioned plant sap samples, the Ion-Selective Electrodes (ISE) are without any competition. The present research is aimed to solve the problem of detection of potassium deficiency prior as Hidden Hunger i.e. early detection to the actual morphological/visible symptoms appears in the crop plants. If the plant potassium deficiency can be determined before the symptoms, then preventive measures can be taken recover the plant health such applying potassium based fertilizer. This will also control the unnecessary usage of fertilizers, improve soil health and reduce water and atmospheric pollution ultimately reducing the cost or expenses of farming.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Jaymin Kanubhai Jadav, Khyati Jagdish Rathod, Junagadh Agricultural University, Junagadh at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

New generation periscope fruit picking device

Students of Birla Institute of Technology & Science, Pilani, Hyderabad, Tania Dutta won the award for developing a prototype of New generation periscope fruit picking device. She carried her project work under guidance of Dr. P Yogeeswari.

The estimated extent of annual post harvest losses are: Fruits, about 30 per cent valued at Rs 13,600 crores and for vegetables about 30 per cent valued at Rs 14,100 crores.

The most probable cause for the losses encountered is the untimely harvesting before proper maturation and the harvesting of damaged fruits along with the good ones and storing them together.The post harvest losses can be minimised to a great extent if the harvesters can see the condition of the fruits on the trees before picking them. Thus, I have come up with a design optimised modified tool structure. We have incorporated the idea of a periscope inside a fruit picker in such a way that it gives a complete view of the fruit so that the harvesters can decide if the fruit has ripened or not and pick accordingly. The device also has a focusing and zooming lens set-up for a better image at the end. The rod in the device are placed in a telescopic fashion. 
This allows flexible height adjustment of the rod according to the fruit height on the tree. The design is simple, convenient to use, does not require much technological knowledge, very cheap, easy to manufacture and provides a great loss minimisation in the long run. This product is mainly targeted to help the poor farmers who are still used to with the traditional old methodologies and equipments and have not yet been exposed to the highly advanced technical automated robotic machineries on which current researches are going on abroad.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Tania Dutta, Birla Institute of Technology & Science, Pilani, Hyderabad at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Eco-Friendly Water Retention Natural Polymer

Students of College of Technology and Engineering, Udaipur, Narayan Lal Gurjar, Shashi Pratap Singh Shekhawat, Ankit Jain won the award for research work of Eco-Friendly Water Retention Natural Polymer. They carried their project work under guidance of Dr. Shailendra Mohan Mathur.

As we know our country is agricultural depending economy and big part of our economy is depends on the agriculture. But production in agriculture is proportional to water availability.

In India 266 districts, in 11 states declared drought affected. The average food grain production between 2010-2011 and 2014-2015 is 255.59 million tons, while in 2015-2016, it is estimated to be at 253.16 million tones. More than 70% districts drought affected in 8 states. The data shows scarcity and unavailability of water causes too many losses. So we tried to create something helpful to retain water for long time, and in this trying we are successful to create a polymer named “Eco-Friendly Water Retention Natural Polymer”. Keeping in mind all the conditions of our country and our farmers we designed this product at low cost with much more efficiency. This polymer is working on properties of SAP. SAP have properties to absorb water of quantities of their own weight. It has more capacity to store water for long time. On testing of our product we found it may retain water for 4 to 6 weeks that means crops irrigated at intervals of 2 to 4 days are now can be irrigated at 7 to 8 days with less water consumption. Therefore, finally farmers can get more crop production in low water consumption. Our natural polymer is designed by use of waste material like banana peels and peepal barks with gel. As all the ingredient used are biodegradable, so our designed product is also biodegradable and completely pollution free i.e. it is easily mixed with soil and does not create any problem in the future.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Narayan Lal Gurjar, Shashi Pratap Singh Shekhawat, Ankit Jain, College of Technology and Engineering, Udaipur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

3D-NuS: A Web Server for Automated Modeling and Visualization of Non-Canonical 3- Dimensional Nucleic Acid Structures

Students of Indian Institute of Technology Hyderabad, L Ponoop Prasad Patro, Abhishek Kumar, Narendar Kolimi won the award for research work of 3D-NuS: A Web Server for Automated Modeling and Visualization of Non-Canonical 3- Dimensional Nucleic Acid Structures . They carried their project work under guidance of Dr. Thenmalarchelvi Rathinavelan.

The inherent conformational flexibility of nucleic acids (DNA, RNA etc.) facilitate the formation of a range of conformations such as duplex, triplex, quadruplex etc., which play crucial roles in biological processes such as mismatch repair, replication, recombination, transcription, translation, gene regulations etc. These unconventional base pairing and structural conformations on DNA/RNA structures at different sequence contexts also induce abruptions in normal cell function which can lead to deformities and diseases (cancer, fragile X syndrome, etc.).

 To understand the role of these unusual nucleic acid structures in aforementioned biological phenomena and diseases, structural details at atomic level is indispensable. But, experimental methods (such as XRAY crystallography, NMR etc.) are not always successful in determining structural details and are very expensive. Further, structural insights about nucleic acid triplexes, which are generally not tractable to structure determination by X-ray crystallography or NMR techniques, are essential to establish their biological function(s). A web server, namely 3D-NuS (http://iith.ac.in/3dnus/), has been developed to generate energy minimized models of 80 different types of triplexes, 64 types of Gquadruplexes, left handed ZDNA/RNA duplexes, RNADNA hybrid duplex along with inter- and intramolecular DNA or RNA duplexes comprising a variety of mismatches and their chimeric forms for any user defined sequence and length. It also generates an ensemble of conformations corresponding to the modeled structure. These structures may serve as good starting models for docking proteins & small molecules with nucleic acids, NMR structure determination, cryo-electron microscope modeling, DNA/RNA nanotechnology applications and molecular dynamics simulation studies. The operational milestones that would be accomplished in future include generation of aforementioned structures with modified nucleic acids such as PNA and LNA, intra-molecular triplexes, complex duplexes and models with user defined structural parameters.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to L Ponoop Prasad Patro, Abhishek Kumar, Narendar Kolimi , Indian Institute of Technology Hyderabad at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Performance Evaluation and Process Optimization for Production of Ready-to-Eat Therapeutic Food Paste in Pilot Scale Unit

Students of Indian Institute of Technology Kharagpur, Rakesh Kumar Raigar, Danie Shajie A won the Appreciation award for research work of Performance Evaluation and Process Optimization for Production of Ready-to-Eat Therapeutic Food Paste in Pilot Scale Unit. They carried their project work under guidance of Dr. H N Mishra.

Severe Acute Malnutrition (SAM) is an important cause of morbidity and mortality in children below five years of age in India, where 8.1 million children are estimated to suffer from SAM. To combat this stumbling block, an indigenously developed readyto-eat therapeutic food (RTE-TF) is the need of the hour, catering the prerequisite of energy dense and nutrient rich ready-to-eat product containing defined calorie and essential nutrients which would be storage compatible, culturally acceptable; easy to administer; control and deliver at low cost for SAM children. A GMP/GHP compliance PLC controlled pilot scale unit has been commissioned in the Agricultural and Food Engineering Department at IIT Kharagpur aligning with the Make in India vision in treating SAM at community level with financial support from Department of Biotechnology, Government of India, New Delhi for the production of RTE-TF.

 Five RTE-TF formulations were developed using locally produced raw material and fortified with micronutrients. A peanut based formulation was processed for the performance evaluation and optimization of major equipment installed in the pilot scale unit. The material and system parameters for primary processing (batch operations) like roasting, deskinning, grinding etc. and PLC based continuous processing (viz. grinding, mixing & homogenizing) were optimized along with the standardization of PLC based clean-in-place (CIP) sanitization system. Physico-chemical, safety and nutritional characterization of the RTE-TF produced in the pilot scale unit was done and complied as per the norms defined by World Health Organization for SAM. The pilot scale process will reinforce the liability for sustainable production of RTE-TF paste which would aid in management of SAM in children in our country.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Rakesh Kumar Raigar, Danie Shajie A, Indian Institute of Technology Kharagpur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

A Non-contact Optical Device for Online Multiplexed Monitoring of Diseases of Military Importance in Fragile and Conflict-Affected Settings

Students of S.N.Bose National Centre for Basic Sciences, Probir Kumar Sarkar, Aniruddha Adhikari, Animesh Halder, Soumendra Singh won the award for developing a prototype of A Non-contact Optical Device for Online Multiplexed Monitoring of Diseases of Military Importance in Fragile and Conflict-Affected Settings. They carried their project work under guidance of Prof (Dr). Samir Kumar Pal .

Jaundice, Anaemia and Hypoxia, the three intimately interrelated health problems in military services particularly in fragile and conflict-affected settings take care of significant preventable casualties. These trio also proved to be the major cause for neonatal and maternal mortality in developing world. On the other hand, conventional gold-standard detection strategy through invasive blood sampling has several drawbacks for neonates and is redundant in fragile and conflict-affected settings. Thus a low cost and robust strategy for diagnosis of these diseases in all adverse conditions is of outmost importance to countries like India where huge number of military personnel are deployed in adverse geographical conditions along the border area and where under-5 mortality rate is alarmingly high. We, developed prototype of a noninvasive, non-contact, affordable, easy-to-use, point-of-care reflectance spectroscopy based device for measuring all three parameters at one go based on the spectral signature of bilirubin, hemoglobin and oxygen saturation from the vascular bed lying under conjunctiva (white portion) of eye. As conjunctiva is white independent of race, age or skin color, the device is useful to all. The indigenously developed software makes the device compatible to e-healthcare with possibility of online monitoring through cloud computing. Thus, this strategy will be extremely helpful in critical/low resource conditions like battle field and high altitude border regions for regular routine health check-up of army people who always devoted their life to protect the nation. The innovative noncontact, low-cost technique is expected to have importance in monitoring jaundice, anemia and hypoxia in developing / underdeveloped countries, where the inexpensive diagnosis with non-experts manpower is obligatory.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Probir Kumar Sarkar, Aniruddha Adhikari, Animesh Halder, Soumendra Singh, S.N.Bose National Centre for Basic Sciences at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

3D bioprinted skin scar model for drug and cosmetic testing

Students of Indian Institute of Technology Delhi, Shikha Chawla, Aarushi Sharma won the award for research work of 3D bioprinted skin scar model for drug and cosmetic testing. They carried their project work under guidance of Dr. Sourabh Ghosh.

Current anti-scar cosmetic products or medicines are not effective enough due to poor understanding of scar pathogenesis. Results of pre-clinical trials on animals do not always extrapolated to humans . Moreover, pharmaceutical companies are facing a major jolt due to European Union ban on animal testing of finished cosmetic products/ingredients (European Union Council Directive 76/768/EEC).

International Cooperation on Cosmetics Regulation is strongly encouraging development of alternatives for drug testing on animals due to ethical concern, to reduce or eliminate the use of animal models. Hence, there is an urgent need for a human cell-based in vitro engineered tissue models to screen drugs/cosmetics for the prevention of scar. Since past 50 years, many international researchers/industries tried to develop tissue engineered skin for transplantation. But tissue engineered skin received limited success in human clinical trials. Uniqueness of our approach is to develop a relatively simpler, human cellbased in vitro tissue engineered skin model that could 1) be used for rapid screening of anti-scar drugs/cosmetics and 2) help to extend our understanding of the cellular signaling pathways. Our model could recapitulate several hallmarks of scar tissue: (1) fibroblasts to myofibroblasts transition and expression of α -SMA; 2) contraction; 3) excessive collagen and reduced elastin secretion; 4) fibrotic ECM protein expression (SPARC and Tenascin); 5) low MMP secretion and 6) involvement of TGF-β/SMAD and Wnt/β-catenin pathways. To the best of our knowledge, no such in vitro models have been reported, hence it is getting major attention of national/international level news media and pharmaceutical companies.

Dr. Harsh Vardhan, Minister of Science and Technology, awarded the Gandhian Young Technological Innovation (GYTI) Appreciation to Shikha Chawla, Aarushi Sharma, Indian Institute of Technology Delhi at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Origgon – A Social Search Engine

Student of Don Bosco High School, Assam, Abhik Saha won the award for developing a search engine Origgon – A Social Search Engine.

Origgon.com is world’s first of its kind social search engine made by 15 year old boy, Abhik Saha. Origgon is a unique innovation to save people from the trouble of finding spam and irrelevant results in their search process. Origgon is a baby step towards our honourable Prime Minister’s vision of “Make in India”.

It gives users the opportunity to find optimal search results based on reviews and recommendations by people. In the space where AI has evolved so far, it’s still not accurate to meet our needs. Every people have their own personalised space and needs set. The job of social search is to full fill that need for every individual, the need might be fulfilled based on more personalised set from one’s social media data, one’s friends circle and all other social stuffs. Origgon, a social search engine where search results will not be based on SEO but by votes of people all over the world. We people are sharing lot of valuable content in the web, let that be picture or text or a emoji or a news article or a meme anything. We share because we believe the content is worth it or at-least for yourself it is important. Taking those recommendation, those likes, those little things the billion people shares every day, to personalise and recommend the results. Link: www.origgon.com

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (GYTI) Award to Abhik Saha, Don Bosco High School, Assam at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Road Accident Detection using Perceptual Attributes of Video

Student of Indian Institute of Technology Kanpur, Dr. Sinnu Susan Thomas won the award for research work of Road Accident Detection using Perceptual Attributes of Video. She carried her project work under guidance of Prof. Sumana Gupta and Prof. K S Venkatesh.

According to Annual Global Road Crash Statistics, nearly 1.3 million people die in road crashes every year, on average 3,287 deaths a day. Road accident detection and vehicle behavior analysis is of great interest to the research community in intelligent transportation systems. Surveillance cameras are ubiquitous on the roads and capture videos round the clock. The enormous data collected by cameras may be time consuming and laborious to scrutinize the occurrence of an accident scenario present in the videos. There is a need to reduce the redundant nature of video so that its contents become succinct using video summarization techniques. The project presents perceptual video summarization techniques to enrich the speed of visualizing the accident content from a stack of videos. The problem of vehicle analysis is formulated as an optimization problem. The results establish the versatility of the proposed summarization model.

This model is formulated using cost function based on the change in the appearance of perceptual features such as motion, color, shape, and size. A selective minimization of the cost function leads to an appropriate video summarization of the event. The experiments were conducted for different types of collision such as head-on collision, rearend collision, single-vehicle collision and intersection collision and summarized the events prior, during, and subsequent to the accidents. The reduction ratio achieved is small and true positive detection is higher compared to the conventional methods. The model used for this project can be used for various surveillance purposes

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (GYTI) Award to Dr. Sinnu Susan Thomas, Indian Institute of Technology Kanpur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Window Solar Cooker

Students of Indian Institute of Technology Bombay, Avinash Prabhune won the award for research work of  Window Solar Cooker. They carried their project work under guidance of Prof. B K Chakravarthy.

The LPG price hikes every month triggered the thought on Solar Energy which could be a clean and abundant source of energy. There are many types of solar cookers available in the market, but they are not that efficient. Each one has its own pros and cons. In a rapidly urbanizing India, the user segment this product is targeted towards are the people who live in high rise buildings because they don’t have space to use solar cooker and the old solar cookers fail to match their fast-paced life style. For using present type of solar cookers, the users need to have open space where they will get continuous sun light and the users need to track the sun all day.

All these usability issues are the reason why urban users are not willing to consider this as an alternative to conventional cooking methods. This new kind of solar Oven will be mountable in the window or wall like a window AC, while facing towards south where sun is available all year round. Thus the accessibility becomes very easy from inside the house itself and the users need not go out. The cylindrical form provides uniform sunlight all day long. The ‘Dabba’ perception about the box-type of solar cooker has been broken by this new design. The efficiency has been improved and the time taken for cooking is drastically reduced, as compared to any other kind of solar cooker.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (GYTI) Award to Avinash Prabhune, Indian Institute of Technology Bombay at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Magnetic tool for nano finishing the holes, vertical and horizontal surfaces

Student of Indian Institute of Technology Delhi, Girish Chandra Verma won the award for research work of  Magnetic tool for nano finishing the holes, vertical and horizontal surfaces. He carried his project work under guidance of Prof. Pulak Mohan Pandey.

The developed tool is based on MAF principle for polishing holes, blind holes, grooves and vertical surfaces. The tool developed in the present work consists of five main components, which are two cylindrical magnets (having magnetic flux density of 0.452 T), a mild steel piece, a copper casing, and an upper head made of mild steel. In the developed tool the magnets were arranged in such a way that, similar pole of both the magnets faces each other. Due to this the magnetic lines of force from both the magnets get directed to radial direction. Using this concept of similar pole facing each other; a high magnetic flux density 0.8 T is achieved around the circumferential area of mild steel piece. The developed tool also produces variable magnetic flux density so that material of different hardness can be finished. For obtaining a variable magnetic flux density, the gap between the upper magnet and ferromagnetic piece is altered with the help of nut and bolt arrangement provided on the upper piece of copper casing and upper head. The size of the developed tool can also be modified by using different sizes of magnets and casing, which can be used to finish hole of different sizes. Experimentation on SS304 stainless steel pipe (with initial surface roughness of 541nm) at an optimized condition resulted in a surface finish of 56 nm. The obtained SEM (scanning electron microscopy) images of finished and unfinished surface have showed that all the scratch marks were removed and finished surface was obtained.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (GYTI) Award to Girish Chandra Verma, Indian Institute of Technology Delhi at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Feasibility Study of Wireless Power Transfer Using Metamaterial

Students of Indian Institute of Technology Guwahati, Amit Kumar Baghel, Shashank Satish Kulkarni won the award for research work of Feasibility Study of Wireless Power Transfer Using Metamaterial. They carried their project work under guidance of Dr. Sisir Kumar Nayak, D. Senthil Kumar.

Wireless power transfer (WPT) is the method to transfer power from the source to load without cables or wires started way back in 1903 by Dr. Nicolas Tesla. Nowadays this technique is being used in many applications such as biomedical transplants, UAVs, mobile chargers, electric vehicle charging, antennas etc. But the major problem with the WPT is the decrease in the efficiency as the distance is increased. In near field, the strength of the field varies inversely as the square of distance and cube of distance for far field. One of the novel ways by which we can increase the intensity of field, thus power transfer is with the help of meta-material.

They are manually engineered with negative refractive index and help in beam focusing. It can act as a super-lens. My innovation is about increasing the efficiency of far-field WPT using metamaterial. The metamaterial pattern is made on the 1. 6 mm thick double-sided FR4 sheet (dielectric constant 0.02) having 0.017 mm thick copper plating on both side of the sheet. A total of 40 arrays having 8 unit cell in each is placed at an optimized distance from the aperture of the proposed horn antenna (Tx antenna). The electric field at the distance of 6 m is measured using the D-dot sensor. The receiver antenna is 2×2 patch antenna having RF to DC conversion schottky diode and matching circuit. To charge the batteries of the cellphone (2900 mAh, 3.8 V), the zener diode with RC filter is placed after the matching circuit. An increase in twice the electric field , thus the received power is seen with the proposed antenna and meta-material.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (GYTI) Award to Amit Kumar Baghel, Shashank Satish Kulkarni, Indian Institute of Technology Guwahati at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

A Novel low cost Polyvinyl alcohol-Nafion-Borosilicate membrane separator for microbial fuel cell treating distillery wastewater

Students of Indian Institute of Technology Khragpur, Bikash Ranjan Tiwari, Md. Tabish Noori won the award for research work of A Novel low cost Polyvinyl alcohol-Nafion-Borosilicate membrane separator for microbial fuel cell treating distillery wastewater. They carried their project work under guidance of Prof. Makarand Madhao Ghangrekar.

Microbial fuel cell (MFC) are bioelectrochmical systems which convert the organic matter present in the wastewater to electricity with the aid of biocatalytic acitvity of a specific group of microorganism i.e. electrogens. MFCs presents a promising solution to both waste removal as well energy generation simultaneously. The high manufacturing cost of MFC is a major hurdle in the path of field scale application. The membrane cost ($1600/m2) alone accounts for around 35% of total MFC capital cost.Hence, development of low cost membranes can ease the path for real world application of MFCs. In the present study, a composite membrane was developed from borosilicate glass incorporated with polyvinyl alcohol (PVA)-Nafion matrix. While utilizing acetate based synthetic wastewater, MFC with PVA-Nafion-Borosilicate membrane exhibited maximum power density of 6.8 Wm-3 and it was comparable with MFC using commercially available Nafion 117 (7.1 Wm-3) membrane separator. Moreover, the method of preparation is simple and cost of the novel membrane is 11- folds lower than commercially available Nafion 117. The study was further extended by utilizing the MFC with the newly developed membrane for distillery wastewater treatment. effluent generated from distilleries are characterized by their high COD and BOD content and acidic pH which can cause serious environmental problems if not properly treated. The MFC was capable of efficiently degrading organic matter present in distillery wastewater in the range of 54.5 – 64.25% along with generating a maximum power density of 4.3 Wm-3. This study demonstrates a novel, low cost, easily synthesizable membrane which was successfully used for treatment of distillery wastewater treatment in MFCs.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (GYTI) Award to Bikash Ranjan Tiwari, Md. Tabish Noori, Indian Institute of Technology Khragpur at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

An Alternative Technology to Produce Biomass-Based Food Grade Flavors, Fuels and Value Added Chemicals

Students of Indian Institute of Technology Delhi, Shelaka Gupta, Md. lmteyaz Alam, Tuhin S. Khan, Ejaz Ahmad, Fatima Jalid won the award for research work of An Alternative Technology to Produce Biomass-Based Food Grade Flavors, Fuels and Value Added Chemicals. They carried their project work under guidance of Prof. M. Ali Haider.

State-of-the-art technologies applied today to convert biomass into high value fuels and chemicals are based on multi-step catalytic transformation steps, which are difficult to commercialize. Here, as an alternative, a technology (TNEW) based on integrated bio and chemo-catalytic reactions is developed, to carry out the desired conversion of biomass in fewer steps, giving higher product yield. In TNEW, 6- amyl-alpha-pyrone (6PP) is identified as a potential biomass-derived platform chemical. 6PP is produced from the fermentation of waste biomass using Trichoderma species and catalytically converted into 2-nonene-4-one, hydric alcohol, δ-decalactone (DDL) etc., under relatively mild processing conditions. While DDL and 2-nonene-4-one showed direct applications as food flavor and aroma, other products may be used as precursors for polymers, pharmaceuticals and hydrocarbon fuels. Three Indian patent applications related to the commercial development have been filed. Socially, the simplistic nature of our technology is expected to have a wider impact on rural economy and environment. For example, at present large volume of waste lignocellulosic biomass is burnt in the national capital region of India, creating air pollution at alarming levels. Farmers burning such valuable biomass may choose to utilize TNEW and ferment the waste biomass directly to produce 6PP which can be subsequently converted to produce high value chemicals. To the best of our knowledge, this is the first time in our country a novel biomass-derived platform chemical is introduced which is different from the top-12 chemicals proposed by the US Department of Energy. This will add into the portfolio of a futuristic bio-refinery, providing a renewable and sustainable solution.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Shelaka Gupta, Md. lmteyaz Alam, Tuhin S. Khan, Ejaz Ahmad, Fatima Jalid, Indian Institute of Technology Delhi at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

A multipurpose low cost biological air purifier

Students of Dr. D.Y. Patil Vidyapeeth, Pune, Neeta Ganesh Wagle, Priti Prabhakar Yewale won the award for developing a prototype of  A multipurpose low cost biological air purifier. They carried their project work under guidance of Dr. Neelu Nawani.

In recent years, air pollution has become a major threat to survival of mankind. Looking at the current problem, biological air purifier would deliver a smart solution to circumvent the problem of indoor and outdoor air pollution caused due to motor vehicles, occupational exposure, cigarette smoke and industrial emissions in particular and will also focus on utility of the air purifier in reducing exposure of public to air pollutants. The team has designed and fabricated a prototype of biological air purifier- “Biosmotrap” comprising of compact carriage assembly with replaceable adsorbent packed in biodegradable pouches or wrappers by means of support meshes and clamping structures and further attached to vents, exhaust or any outlet from where gases are released in any process. The microbial biomass and/or natural bio-materials were employed in the form of solid porous material as an adsorbent. The adsorbent is configured to adsorb air pollutants like smoke, aerosols, particulate matter, flue gases, soot or other air pollutants. The shelf life of adsorbent depends on the concentration of air pollutants from the source point. It reduces the levels of organic as well as inorganic pollutants from the air. The onetime cost of carriage assembly is incurred with each biological air purifier. It can be reused for longer duration until it breaks or needs repair. Also, with the use of recyclable adsorbent material the cost per air purifier is lowered by making it affordable to everyone. This lowers the overall cost of maintenance when compared to conventional air purification technologies and increases its utility by encouraging public at large to use such devices. The fabricated prototype is easy to operate, cost-effective, recyclable and environmental friendly.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Neeta Ganesh Wagle, Priti Prabhakar Yewale, Dr. D.Y. Patil Vidyapeeth, Pune at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Roll Pure – Rolling Water Purifier

Students of Indian Institute of Technology, Madras ,Ramesh Kumar, Swathy Ravindran won the award for developing a prototype of Roll Pure – Rolling Water Purifier. They carried their project work under guidance of Prof. Thalappil Pradeep.

In rural India, people, mostly women and kids, still carry water on their head or shoulder from available local water bodies, sometimes even carrying non-potable water. According to a survey carried out in 2012 by National Sample Survey Office (NSSO), about 54% of women from rural areas travel between 200 meters to 5 kilometers, average 20 minutes a day and additional 15 minutes to fetch water, amounting to 27 days of wages per annum for an individual. According to NSSO statistics, less than 10% of rural Indian household has the facility to treat water at home before its end use. This whole process results in physical fatigue of women and waterborne diseases such as diarrhea, anemia and child mortality hence many resulting postaffects. Roll Pure – Rolling water purifier provides solution for the overhead transportation of nonpotable. A user (women) can fill 40 liters of raw water from any water source (i.e. river, canal, pond, municipal hand-pump or tap etc.) and roll it to home, with minimum time required for transportation without any physical fatigue. To make fed water potable, a 1) hand-operable pump and 2) modular geo-genic contaminant specific cartridge is used. Modular geo-genic contaminant specific cartridge has 1) biocidal material, 1000 times biocidal then silver nanoparticles to kill bacterial and viral contaminants and 2) nano-composite material to remove soluble chemical contaminants. To get chemical and biological contaminant-free water with high output flow rate, a pressure differential is generated using bellow pump. Roll Pure can provide chemical and biological contaminant free water to India’s rural BoP with minimal transportation effort and without any power.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Ramesh Kumar, Swathy Ravindran, Indian Institute of Technology, Madras at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Point of Care Nano Diagnostic Kit for Brucellosis

Students of Institute of Chemical Technology, Mumbai, Rohit Shivaji Pawar, Swati Suhas Vyas won the award for developing a prototype of Point of Care Nano Diagnostic Kit for Brucellosis. They carried their project work under guidance of Dr. Vandana B. Patravale.

Brucellosis, a neglected global zoonotic infectious disease is transmitted to humans through consumption of unpasteurized dairy products and direct contact with afflicted animals. Presence of bacteria such as Brucella spp. in dairy products is an immense risk to public health. The innovation herein describes the development of immunochromatographic diagnostic kit (ICDT) based on fluorescence silica nanosensors that serves as a promising nanodiagnostic approach for detection of intact Brucella antibodies in nonserological samples eliminating painful blood collection procedures. Point of care immunoassays are rapid as they can quickly screen various samples in relatively shorter duration, are sensitive, specific, offer great advantage in accurate and fast diagnosis of infectious diseases. We have fabricated a point of care rapid diagnostic assay that employs fluorescent, micellar silica nanosensors conjugated with lipopolysaccharides (Indian patent application 3183/MUM/2013) capable of specifically detecting Brucella IgG antibodies in non-serological samples of afflicted animal (milk, urine, saliva) and human samples (urine, saliva).

 

The developed kit holds its industrial application in agricultural , biotechnological and pharmaceutical arena. We have successfully fabricated and evaluated the aforementioned kit. The developed ICDT provides a rapid, reliable, point-of-care, accurate and reproducible results in accordance with PCR and ELISA results with high sensitivity and specificity.Additionally, well defined antigenic components and surface biomarkers of various disease causing microbes can be broadly incorporated within the purview of this technology for accurate and rapid detection of suspected bovine pathological conditions, and can largely enable rapid field testing that can be implemented in farms and food Industry. Since the developed technology is novel, cost effective yet scalable; it fits “Make In India” initiative to foster innovation, enhance skill development, create intellectual property and generate revenue.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to  Rohit Shivaji Pawar, Swati Suhas Vyas, Institute of Chemical Technology, Mumbai at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Design and development of Phase Change Material (PCM) based Milking cum Cooling Pail

Student of National Dairy Research Institute, Bangalore, Ravi Prakash won the award for developing a prototype of Design and development of Phase Change Material (PCM) based Milking cum Cooling Pail. He carried his project work under guidance of Dr. Menon Rekha Ravindra and Dr. M. Manjunatha.

It is imperative to immediately cool milk from its drawing temperature (37 °C) to below the critical temperature (10 °C) in order to preserve the safety and quality of milk and its derived products. 

In developed and large-scale commercial dairy enterprise, this critical step in post-production processing of milk is achieved by integrating the milking machine with chilling unit accessorised with suitable piping and storage tanks. However, in a country like India where most of the dairy farmers belong to a class of millions of scattered small scale producers (0.5 – 10 L per head), such sophistications are neither pragmatic nor economical at the field level. This project aims at developing a system/device that could instantly cool small volumes of milk at the on-farm level preferably simultaneous to the milking to minimize the time gap between milk production and milk cooling below critical limit, even if the farmer has only one animal. 

Considering the gap between demand and supply of electricity in rural areas, the suitable nanofluid based phase change material with enhanced cooling energy storage capacity was primarily designed, evaluated and to be filled into the double jacketed space of an insulated milking cum cooling pail accessorised with a charger (a hermetically sealed well-matched refrigeration unit). The operation, handling and maintenance of the pail is farmer-friendly, sealed and resembles as daily used milking pail. This technology is envisaged to have very high socioeconomic utility; by helping millions of small scale milk producers/dairy farmers in developing countries like India in maintaining quality of milk and milk products, and contributing to the overall economy of the country.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Ravi Prakash, National Dairy Research Institute, Bangalore at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Batteryless IoT Sensing Node

Students of Indian Institute of Technology Kharagpur, Anandarup Mukherjee, Arijit Roy, Sanku Kumar Roy won the award for developing a prototype of Batteryless IoT Sensing Node. They carried their project work under guidance of Prof. Sudip Misra.

Being a primarily agrarian nation, India still has a large chunk of its population earning their livelihood through agriculture or its associated practices. However, the recent climatic changes are disrupting the time-tested and age-old agricultural practices, which were mainly intuition based or seasonal.

Despite the availability of scientific means of agricultural practices in India, they are not practiced at their full potential due to prohibitive initial costs or high maintenance costs. In our proposed innovation, we specifically are focusing on sensor nodes which are used for monitoring the agricultural field parameters. We have developed a battery-less sensor node which is designed to be placed in the field, without any chance of getting their power supplies replenished. We believe that reducing certain essential components in a sensor-based system, such as the battery, the net cost of each sensor nodes comes down, which in turn makes it more affordable to the masses. As purchasing the almost maintenance-free sensor node is a one-time investment for the farmer, the benefits of the purchase in terms of increased water savings, higher yield, and power savings, far outweigh the initial costs. The only recurring cost to be borne by the farmers is the basic cellular data connectivity for the mobile charger and aggregator node, and minimal subscription charges for using the server-based analytics. Additionally, this approach not only increases the functional lifetime of sensor nodes beyond the typical 1-2 years mark but also makes it much cheaper in the long run. Being a pick-and-place solution, it can be easily operated and handled by people with no prior technical know-how, especially in the rural areas. Link: https://youtu.be/1IMcryb-cfY

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (GYTI) Award to Anandarup Mukherjee, Arijit Roy, Sanku Kumar Roy, Indian Institute of Technology Kharagpurat the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Nano based soil conditioner for agricultural application

Students of  Tezpur University, Assam , Pallabi Das, Kasturi Sarmah won the award for research work of Nano based soil conditioner for agricultural application. They carried their research work under guidance of Dr. Sanjay Pratihar and  Dr. Satya Sundar Bhattacharya.

Available forms of iron, copper, and manganese in soil are scarce especially in arid regions where the soil pH varies from neutral to alkaline range, leading to acute deficiency of these micro-nutrients. Crop production in such soils is severely hindered. Iron salts such as ferrous sulphate has routinely been used to treat Fe deficient soil that greatly affects phosphorous availability and results in soil acidification in the long run. We developed easy, novel, and large-scale synthetic routes (1.5 Kg to 15 Kg in a single batch) to manufacture iron(oxalate) capped metal oxide [Fe(ox)-Fe3O4 (OCIO), Fe(ox)Fe-MnOx (OCIMn), and Fe(ox)Fe-CuOx (OCICu)] nanomaterials that are wonderful soil conditioners for increasing micro-nutrient availability to plants with least toxicity (Patent application no. 201631010727).

 Their Moderate (10 ppm) exposure improved seed germination and they were harmless to beneficial soil bacteria. We also recorded negligible oxidative stress in plants up to 50 ppm exposure levels of the nanomaterials. OCIO, OCICu, and OCIMn balance the soil pH; sustain Fe, Cu, and Mn availability without increasing soil acidity thereby promoting release of NPK through benefitting soil microbial health. These nanomaterials corrected micronutrient deficiency in soil and significantly augmented tomato production in farmer’s field by upregulation of vital genes responsible for root growth, photosynthesis, and N-assimilation (RSL4, MATE8, Ferredoxin, GS2, GOGAT, and NR). The crop yield was 2.3-3.4 folds greater in OCIO with 10 folds lower dose (2 kg/ha) than Fe-EDTA and FeSO4 (20 kg/ha). Moreover, the quality and storage longevity of the produce was remarkably superior in plants treated with the synthesized materials than conventionally used micronutrient salts (FeSO4, MnSO4, and CuSO4).

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Pallabi Das, Kasturi Sarmah,  Tezpur University, Assam at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Ekdeep Singh Lubana

SNAP – A RAW images’ based setup that can calculate nutrient concentration in leaves

Student of Indian Institute of Technology Bombay, Ekdeep Singh Lubana won the award for developing a prototype of  SNAP – A RAW images’ based setup that can calculate nutrient concentration in leaves. He carried his project work under guidance of Prof. Dr. Maryam Shojaei Baghini.

Since long, efforts have been made for determining the concentration of nutrients in soil, which, thereafter, help in the calculation of required fertilizer content. However, the conventional methods incorporating chemical methodologies for soil testing have humongous limitations – finite number of samples can be tested in a given period of time (around 1000 samples per month); the amount of time required for the analysis can render the analysis obsolete; and, many-a-times, the analysis never reaches the farmer. All these issues put a stigma in a farmer’s mind, because of which he refrains from getting a soil analysis and uses a heuristic approach of 50kgs of fertilizer per hectare.

 

Such a methodology leads to acidification of soil, hampering the possible yield for the farmer. Due to over-fertilization, India faces an average ratio of 24:1 for N:P, whilst the ideal ratio is 4:1. Hence, our team has come up with SNAP, a handheld, patented device based on the principles of “Multispectral-Imaging” to capture images of a leaf at specific wavelengths, which have been optimally scrutinized and calculated for the specific purpose of determination of nitrogen concentration in a leaf. In a controlled environment (a minimal reflection apparatus with precisely-located illumination sources for constant geometry), modified GIS-based spectral parameters are correlated with leaf-nutrient content. We have expanded to further magnesium and potassium, and are currently concentrating on expansion to 6 more vital nutrients. SNAP helps tackle the aforementioned delay in the chemical analysis solution – all the while maintaining high levels of accuracy – by delivering a cost-effective, affordable technology that the farmer can use himself – hence making the farmer self-reliant.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Ekdeep Singh Lubana, Indian Institute of Technology Bombay at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

NanoSpermviricide Gel : A Dual Acting Aid for Prevention of Unintended Pregnancy and Unprotected Sexual Intercourse Associated HIV

Students of Institute of Chemical Technology, Mumbai , Amit Girishkumar Mirani, Prashant Girish Upadhaya won the award for research project of NanoSpermviricide Gel : A Dual Acting Aid for Prevention of Unintended Pregnancy and Unprotected Sexual Intercourse Associated HIV. They carried their research work under guidance of Dr. Vandana B Patravale.

Prevention of HIV infection and unintended pregnancy has become a worldwide priority to reduce the health burden in women. Currently, various physical and chemical barriers are available in the market to serve this purpose individually, however, none of the simultaneous intervention approaches exists in the market with very few under clinical investigation. We propose novel “NanoSpermViricide Gel” for simultaneous prevention of HIV-1 infection and unintended pregnancy. NanoSpermViricide Gel is a combination of HIV-1 inhibitor (Tenofovir disoproxil fumarate) with non-hormonal contraceptive (Quercetin) loaded in o/w microemulsion. Tenofovir disoproxil fumarate (TDF) curbs nucleotide reverse transcriptase enzyme while Quercetin downregulates p24 antigen production and HIV-1 entry inhibition. Additionally, Quercetin exerts both systemic and local contraceptive activity by decreasing the Ca+2 ATPase. The TDF and Quercetin was loaded in o/w microemulsion and was gelled using optimized concentration of Carbopol (1% w/w) to form a NanoSpermViricide gel with globule size in the range of 20-50nm. The developed gel exhibited slow release profile (Coitus independent behaviour), thereby improving the consumer compliance. The in vitro anti-HIV activity assessed using β-galactosidase assay indicated 6times increase in anti-HIV activity of TDF + Quercetin loaded o/w microemulsion (IC50 0.0052µM) as compared to Quercetin loaded o/w microemulsion (IC50 0.030 µM). Similarly, the in vitro spermicidal activity revealed that the 100x dilution of combination TDF + Quercetin o/w microemulsion based gel exhibited 10 times increase in inhibition of sperm motility as compared to conventional quercetin and combination gel formulation. The results ensure the enhanced efficacy by dual mechanism of action of developed NanoSpermViricide Gel to cater to the increasing social burden instigated due to HIV infection and unintended pregnancies, especially in developing nations.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Amit Girishkumar Mirani, Prashant Girish Upadhaya, Institute of Chemical Technology, Mumbai at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Super-Resolution Ultrasonic Imaging (SUI)

Student of Indian Institute of Technology Madras, Kiran Kumar Amireddy won the award for the research project Super-Resolution Ultrasonic Imaging (SUI). He carried his research work under guidance of Dr. Krishnan Balasubramaniam and Dr. Prabhu Rajagopal.

Ultrasonic Imaging (UI) is widely used for characterization of materials in industry and biomedical applications because it is affordable and does not have risk of radiation. However conventional UI systems suffer from poor resolution in the range of millimeters, due to the Rayleigh limit to half the operating wavelength. Electromagnetic (EM) methods such as X-ray computed Tomography (CT), Magnetic Resonance Imaging (MRI) etc., can yield resolution ranging to micrometers or nanometers, but these are expensive and carry a risk of radiation. 

Due to the limitations of UI, EM-based methods are often the only solution, which in parts of the world, are beyond the reach of healthcare providers and industrial inspectors. Improving the resolution of UI systems will make it possible to complement or replace X-ray CT systems used in medical diagnostics and characterization of industrial components. The proposed project seeks to overcome the limitation of UI by addressing the classical diffraction limit in imaging using custom designed holey meta material lenses. Using the principle of Fabry-Perot resonance, this meta material amplifies the evanescent waves in the structure (being imaged) to the far field. The project demonstrated SUI applications to sub wavelength resolution, imaging down to a feature size of λ/25 and characterization of defects in components. The results have yielded some of the highest resolution capabilities achieved experimentally in the ultrasonic regime. This project also yielded a cost-effective method of making meta-lenses using plastic straw tubes sourced off-the shelf.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Kiran Kumar Amireddy, Indian Institute of Technology Madras, at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

A Low-Cost Disposable Microfluidic Biochip for malaria diagnosis

Students of Indian Institute of Technology Hyderabad, Brince Paul K, Asisa Kumar Panigrahi  won the award for developing a prototype of  A Low-Cost Disposable Microfluidic Biochip for malaria diagnosis. They carried their project work under guidance of Prof. Shiv Govind Singh.

Malaria is one of the leading life threatening infectious disease in underdeveloped and developing countries. According to the latest report (2016) from world health organization (WHO), there were 212 million cases of malaria and an estimated 429, 000 malaria deaths. Malaria is caused by protozoan of the genus Plasmodium spread by female Anopheles species mosquitoes. Among these, Plasmodium falciparum (P. falciparum) is the most severe form of malaria and interest is focused on the detection of Plasmodium-specific proteins. One of these, falciparum histidinerich protein II (HRP II) based assays shows the better sensitivity and specificity compared to those of other proteins for the detection of P. falciparum. At present, there are several clinical methods to diagnosis malaria by detecting histidinerich protein II. However, these techniques are time consuming, expensive, and require a trained technician. In the view of the above, the development of a simple, cheap, and fully integrated point-of-care biochip is extremely required for early detection of malarial parasites and prevention of malarial epidemic. Here, we present the realization of a portable, flexible, and low cost biochip for quantitative malaria diagnostic testing at the point-of-care. The biochip incorporates a sensing platform integrated with a three-electrode system and microfluidics fabricated via low cost printing and tune transfer method. The sensing electrode consists of malarial specific antibody conjugated nanofibers. Upon recognizing the presence of even a trace of malaria’s biomarkers in blood serum, the device registered a signal. It will be useful in rural areas where diagnostic facilities are not available readily. This fully integrated biochip offers a promising cost-effective approach for detection of several other infectious disease biomarkers for point-of- care diagnostics.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Brince Paul K, Asisa Kumar Panigrahi, Indian Institute of Technology Hyderabad at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

A Novel Strategy to Block Malaria Transmission

Students of Indian Institute of Science, Bangalore, Divya Beri, Shweta Chaubey, Aparna Sudhakar won the award for the research project Understanding the Design Principles of Protein Nanosensor to Combat Multidrug Resistant Enterobacteriaceae. They carried their research work under guidance of Prof. Utpal Tatu.

Malaria is one of the most prevalent infectious diseases in India. Malaria parasites have a complex life cycle with two forms in the human host; asexual forms that cause the clinical manifestations and sexual forms (gametocytes) which are transmissible forms of the parasite leading to its spread from a diseased host to a healthy host via the vector. Most drugs that are administered target only asexual forms and are in fact, reported to enhance the number of gametocytes; thus, creating a silent reservoir of parasites which potentiates further transmission. Recent reports have suggested an upsurge of asymptomatic malaria which does not manifest in clinical illness but represents individuals that can sustain transmission. Due to very low number of transmissible gametocytes found in clinical cases/asymptomatic malaria, incapability of malaria rapid detection kits (RDT) to differentiate between asexual and sexual stages and induction of clinical gametocytes with most front-line antimalarial drugs, control and elimination of malaria are nearly impossible. Given the essentiality of this stage for parasite survival and propagation, our group demonstrated that redox stress created by the parasite’s own growth is responsible for the commitment to gametocytes (Chaubey et al, Journal of Biological Chemistry, 2014).

Our study, for the first time, shows a physiological metabolite homocysteine linked to gametocytogenesis in in vitro cultures as well as in the mouse model of cerebral malaria (Beri et al, Nature Scientific Reports. 2017). We propose the application of this finding to develop transmission blocking molecules. Molecules targeting homocysteine may prove as attractive therapeutic interventions in blocking commitment to sexual stages. Its administration, along with currently marketed drugs against asexual stages, will ensure complete abrogation of the parasite.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Divya Beri, Shweta Chaubey, Aparna Sudhakar, Indian Institute of Science, Bangalore, at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Smartphone-based impedimetric disposable biosensor for detection of cardiac biomarkers

Students of Indian Institute of Technology Bombay, Debasmita Mondal, Sourabh Agrawal won the award for developing a prototype of Smartphone-based impedimetric disposable biosensor for detection of cardiac biomarkers. They carried their project work under guidance of Dr. Soumyo Mukherji.

A smartphone-enabled disposable, label-free, impedimetric biosensor to detect two common cardiac biomarkers, Myoglobin (Myo) and Myeloperoxidase (MPO) is developed. The device consists of a sensor and a module for interfacing with smartphone. The sensor, fabricated on Whatman filter paper, is coated with a conducting polymer, polyaniline (PAni) and immobilized with antibodies specific to each biomarker protein. Non-specific active regions of the sensor are blocked by treatment with bovine serum albumin. Electrodes for AC impedance measurement are deposited using conductive silver paste. Binding of target protein to specific antibody affects the dielectric constant between the electrodes, thus changing the impedance. Myo and MPO in buffer solution are detected from 100 ng/mL – 50 μg/mL within 100 Hz – 1 kHz. Detection limit obtained for these biomarkers spiked in human serum is 500 ng/mL. The developed biosensor uses inexpensive materials and fabrication techniques, detects cardiac biomarkers in clinically relevant concentrations rapidly (~20 minutes), can be disposed in an environment friendly manner, thus making the sensor suitable for diagnostic applications. To make a handheld, portable point-of-care device, a plug and play module for smartphone is developed providing a cost and space effective solution. Prepared module acts as a peripheral to the phone and can be carried in pocket along with headphone. A lowpower and low-cost potentiostat is designed in the peripheral which connects to the audio jack and gets power from the USB port of smartphone. Frequency range of the peripheral is limited to audio range (10 Hz – 10 kHz). Maximum duration each frequency signal can be generated is 5 Seconds. Onetime buying price of a single unit at research level is ~INR 1500 along with a minimal price for cartridge i.e., the sensor.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Debasmita Mondal, Sourabh Agrawal, Indian Institute of Technology Bombay at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Design of Low Cost Infrared Vein Detector

Student of Indian Institute of Technology Bombay, Trivikram Annamalai won the award for the research project Design of Low Cost Infrared Vein Detector. He carried his project work under guidance of Prof. Purba Joshi and Prof. B. K. Chakravarthy.

Vein Detector Device

A study states that for 16 out of every 100 patients it is difficult to spot veins and they have to undergo multiple vein punctures to find the correct vein -This problem is even more profound in cases of children, dark skinned, obese and elderly people which is painful and leads to rashes/marks on patient’s skin. The current products in market which address this issue are extremely expensive, not hygienic, complex to use and bulky. The proposed solution tries to solve the above mentioned issues- while also being ergonomic and aesthetically designed. The device works based on NIR spectroscopy, where infrared waves are absorbed differently by oxygenated and de-oxygenated blood in the veins there by appearing darker – this helps the doctors and nurses to locate the veins easily and conduct one successful veni puncture instead of multiple painful ones. The designed device would bring affordable healthcare to the bottom of the pyramid and immensely benefit small clinics and hospitals, blood banks, blood test labs, etc. In delivering effective medical treatment.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (GYTI) Award to Trivikram Annamalai, Indian Institute of Technology Bombay at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Decellularized Corneal Matrix (DCM) Based Injectable Hydrogel For Strengthening Cornea Matrix In Severe Corneal Keratoconus

Students of Indian Institute of Technology Hyderabad, Shibu Chameettachal, Dr. M S Sridhar won the award for the research project Decellularized Corneal Matrix (DCM) Based Injectable Hydrogel For Strengthening Cornea Matrix In Severe Corneal Keratoconus. They carried their research work under guidance of Dr. Falguni Pati.

Keratoconus (KC) has been classically described as a non-inflammatory pathology, characterized by a conical shape of the cornea, as a result of thinning and protrusion and finally blindness. The etiopathogenesis is still under research and it may be the final manifestation of diverse pathologic processes. Keratoconus (KC)is considered the most common ectatic disorders of the cornea associated with corneal biomechanical instability. The existing treatment procedures are either risky or complicated surgical interventions. We propose an extracellular matrix based tissue engineering approach as an alternative treatment strategy by thickening the stromal area using a novel injectable decellularized caprine cornea matrix (DCM) hydrogel that would integrate with the existing thin stroma. Upon longer time period the filled area becomes transparent via remodelling with the cues from microenvironment. We envision that this technique has a huge potential to replace current treatment strategies those are complex surgical procedures like ICRS, DALK , PK, Bowmans layer transplantation and collagen UV crosslinking treatment which required highly skilled hands and make it risky and costly. We believe that this approach has the potential to change the clinical landscape by eliminating the current dependency on surgery and most importantly the success of this project will reduced the dependency for human cadaveric cornea for transplantation.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Shibu Chameettachal, Dr. M S Sridhar, Indian Institute of Technology Hyderabad at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Miniaturized Fluorescence adapter for Fluorescence Sputum Smear Microscopy using bright-field microscope

Students of Indian Institute of Technology Delhi, Vikas Pandey, Pooja Singh, Saurabh Singh won the award for developing a prototype of Miniaturized Fluorescence adapter for Fluorescence Sputum Smear Microscopy using bright-field microscope. They carried their project work under guidance of Dr. Ravikrishnan Elangovan.

TB infection is one of the major healthcare problems in India. The bright-field sputum smear microscopy (SSM) is the most common method used for TB diagnosis in India, however SSM has poor sensitivity. Consequently, only 64% of total TB infected patients are being diagnosed and treated. Every single undiagnosed TB patient infects at least 10-15 healthy individuals, keeping the vicious disease cycle going. WHO has recommended LED-Fluorescence Microscopy with higher sensitivity for TB diagnosis in high TB burden countries like India. The adoption of LED-FM has been slow mainly due to high cost (approximately~2lakhs INR after subsidy), additional infrastructure, training and maintenance of new fluorescence microscope.

India has approximately 14000 RNTCP centers (each caters approximately 100,000 people), but only 2500 centers has LED-fluorescence microscopes. This diagnostic infrastructure gap between the actual requirement and availability is a major bottleneck. At IIT Delhi, We have developed a unique fluorescence microscopy technology, cTIRF: compact Total Internal Reflection Fluorescence”. The cTIRF converts a simple brightfield microscope to fluorescence microscope without any hassle of tedious illumination mechanism, optical filters, and additional lens installation. This 3D-printed module is highly compact (~approx size of calculator), robust, cost effective and allows rapid (lesser than 2mins) TB diagnosis without additional infrastructure, cost and training. While the sputum sample processing, smear preparation and auramine-O staining remains same as recommended by WHO. The clinical validation of cTIRF is running at 2 hospital sites. This affordable technology is a cost-effective way of upgrading the existing microscopes for fluorescence TB diagnosis. In alignment of Govt. of India mission to eradicate TB by 2025, the cTIRF can be a scalable solution for easy and rapid deployment across India.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Vikas Pandey, Pooja Singh, Saurabh Singh, Indian Institute of Technology Delhi at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Two week WIPO-INDIA Program

WIPO-INDIA Summer School on Intellectual Property( 2 to 13 July 2018)

WIPO Academy, the RGNIIPM Nagpur and the National Law University Nagpur, hosting WIPO-INDIA Summer School in Nagpur, India.  The Summer School program provides an opportunity to students and young professionals to acquire deeper knowledge of each domain of Intellectual property (IP) and role and functions of WIPO. The program consists of lectures, case studies, simulation exercises and group discussions etc.

Basic Information

Venue RGNIIPM & NLU Nagpur
Registration date 22 March  to  15 May 2018
Payment          date 21 May  to 15 June 2018
Training Course date 2  to 13 July 2018
Language English
Certificate WIPO, RGNIIPM & NLU
Course Administrator summerschool.india@wipo.int
Further details rgniipm.ipo@nic.in    9922453057 / 9422812261 / 9422809065

Eligibility: The Summer School is open to 50 Participants like,

  • Students(graduate and postgraduate) and
  • Young professionalsfrom any field of study or discipline.
  • All applicants are required to have successfully completed the Six week free WIPO distance learning General Course on Intellectual Property (DL101).

                  for course visit     https://welc.wipo.int/acc/index.jsf?page=courseCatalog.xhtml

Documents to be uploaded compulsorily:

  • Motivation letter for Summer School (reason for applying & what hope to gain from the Summer School) (Maximum 300 words)
  • Recent Curriculum Vitae/Resume
  • Identification documents such as passport or National ID
  • DL101 Course Certificate (distance learning 6 week free online WIPO course)

Registration Fees: Registration fees are payable upon notification of acceptance.

Ø  Students & young professionals from developing countries and countries in transition and residing in those countries:

(i) Students: US$ 100

(ii)Young professionals: US$ 200

Ø  Students and young professional from developed countries:

(i) Students: US$ 150

(ii) Young professionals: US$ 300

For further details and Online Registration for WIPO Summer school:-

rgniipm.ipo@nic.in  9922453057 / 9422812261 / 9422809065 / 0712-2542961 / 2542979 / 542969

http://www.wipo.int/academy/en/courses/summer_school/

https://welc.wipo.int/acc/index.jsf?page=wssCatalog.xhtml&lang=en

Understanding the design principles of protein nanosensor to combat multidrug resistant enterobacteriaceae

Student of Indian Institute of Technology Madras, Abhishek Narayan won the award for the research project Understanding the Design Principles of Protein Nanosensor to Combat Multidrug Resistant Enterobacteriaceae. He carried his research work under guidance of Dr. Athi Narayanan N.

Developing a treatment for common gastric disorders that affect humans is an active area of research. Enterobacteriaceae generally cause these disorders – the most recognizable among these is E. coli. While antibiotics are generally employed upon infection, a growing concern is the emergence of antibiotic resistance in bacteria – wherein they ‘acquire’ genes that can code for enzymes to break down the chemical antibiotics – will effectively reduce the impact of antibiotics and make the human population vulnerable. In this regard, it is necessary to understand how pathogenic genes are expressed in bacteria upon infection. As humans are warm-blooded, it has been proposed that the constant body temperature triggers the expression of toxic genes in bacteria. This raises questions on the molecular mechanism by which bacteria sense temperature. Natural candidates for sensory behavior in biological systems are proteins – small molecular machines (dimensions of ~10 Å) that could potentially change their conformation (i.e. the relative arrangement of atoms) upon temperature changes. To tackle these questions, we studied a putative thermo-sensory protein Cnu, through numerous biophysical techniques, theoretical modeling and simulations. In our work, we consistently show that Cnu senses small temperature changes through modulation of a particular part of helical structure that increasingly samples various conformations with increasing temperature. Our work clearly points out that upon infection and at the body temperature of 37 °C the structure of Cnu is partially melted that in turn eliminates binding to the partner protein and hence promotes toxic gene expression. To summarize, we explain the macroscopic bacterial infection phenomenon through specific changes in the interaction profiles at the microscopic molecular level, an area we believe that could potentially contribute to the development of new drugs to control bacterial infection.

The Hon’ble President of India, Shri Ram Nath Kovind awarded the Gandhian Young Technological Innovation (BIRAC – GYTI) Award to Abhishek Narayan, Indian Institute of Technology Madras, at the GYTI 2018 Awards function held at Rashtrapati Bhawan on March 19, 2018.

Various Types of Steel

Although steel consists mostly of iron and carbon, the World Steel Association reports that more than 3,500 grades of steel are in existence, each featuring unique chemical, physical and environmental properties. The amount of carbon, additional alloying elements, and level of impurities contained determine the properties of each grade. Even though the most commonly used grades of steel contain between 0.1 and 0.25 percent carbon, some can have a carbon content of up to 1.5 percent. All grades of steel contain elements like manganese, phosphorus, and sulfur. While the last two are known to have deleterious effects on the strength and durability of steel, manganese has significant benefits.

 

Steel is produced in various forms, each featuring unique properties that may have been manipulated to fit specific applications. These properties are the basis of every grading system used to distinguish one form of steel from the other. According to AISI, steels can be grouped into the following categories depending on their chemical compositions or metal alloy contents:

 

• Carbon steels

• Alloy steels

• Tool steels

• Stainless steels

 

Carbon Steels

Carbon steels contain iron, carbon, and trace amounts of other alloying elements. Carbon is, however, the main alloying constituent of carbon steels, which account for approximately 90 percent of all steel productions. Because it has small enough atoms, carbon can travel through iron’s crystal lattice, filling the gaps between the metallic atoms and distorting the metal’s lattice slightly. As a result of this, the metal becomes much stronger and a lot more rigid. Carbon is the hardest element, which is why carbon steel products are also very hard. Varying the percentage of carbon produces steel with different qualities. However, higher carbon content often translates to stronger yet more brittle steel. Depending on the level of carbon contained, carbon steels can be classified into the following groups:

• Mild or low carbon steels that contain up to 0.32 percent carbon

• Medium carbon steels, containing 0.30-0.59 percent carbon

• High carbon steels, known to contain over 0.6-0.99 percent carbon

• Ultra-high carbon steels that usually contain about 1.0–2.0 percent carbon

 

Also known as wrought iron, low carbon steel is the commonest and most cost effective form. It is easy to work, making it suitable for decorative products like lamp posts and fencing. As one of the stronger variants, medium carbon steel is often used to forge large structural applications and automotive components while high-carbon steel is mostly used for high-strength wires and springs. Also known as cast iron, ultra-high carbon steel is the hardest form of them all and often used for knives, axles, punches and other special purposes. Since carbon steels do not contain chromium, they tend to corrode faster than almost every other type of steel.

 

Pros

Depending on the variant, carbon steels are:

• Strong

• Durable

• Extremely hard

• Ductile

• Affordable

• Resistant to wear

• Malleable

• Offer exceptional machinability when treated with sulfur

• Can be tempered to great hardness

 

Cons

• Poor rust resistance

• Relatively low tensile strength

• Some types suffer from yield-point runout and can, therefore, require high levels of maintenance.

 

Alloy Steels

The name comes from the fact that steels in this group contain a small percentage of other metals besides iron. Alloy steels contain common alloy metals in varying proportions, which makes this type of steel suitable for specific applications. These alloy metals include aluminum, manganese, nickel, titanium, silicon, copper, and chromium, the addition of which produces properties that are different from those found in regular carbon steels. When added, alloying elements can change properties like strength, ductility, formability, hardenability, and ability to resist corrosion. For instance, stainless steel is produced by adding chromium and nickel whereas the addition of aluminum results in a more uniform appearance. On the other hand, the addition of manganese is known to make steel extremely hard and strong. Alloy steels can have diverse mechanical properties due to the broad range of compositions possible.

 

Pros

Depending on the variant, alloy steels are:

• Economical

• Widely available

• Easy to process

• Resistant to corrosion

• Hard

• Strong

• Responsive to heat treatments

 

Cons

• The hardness has a negative impact on workability

• Can be allergic, especially if it contains nickel

 

Because of the properties mentioned above, alloys steels serve a broad range of applications including the manufacture of pipelines, transformers, auto parts, electric motors and power generators.

 

Tool Steels

This type of steel is alloyed at very high temperatures and often contains hard metals like tungsten, cobalt, molybdenum and vanadium. Since they are not only heat resistant but also durable, tool steels are often used for cutting and drilling equipment. Even so, there are various types of tools steels, each containing varying quantities of different alloy metals. As a result, each type of tool steel offers a different level of heat resistance and durability.

 

Pros

• Extremely durable

• Highly heat resistant

• Strong

• Hard

 

Cons

• Limited application

• Difficult to manipulate

 

Stainless Steels

Although stainless steels comprise of several metal alloys, they usually contain 10-20 percent chromium, making it the primary alloying element. Compared to the other forms of steel, stainless steels are approximately 200 times more resistant to rusting, especially the types that contain at least 11 percent chromium. As a result, stainless steel is highly valued for its ability to resist corrosion. Based on their crystalline structure, stainless steels fall into one of the following categories:

 

1. Austenitic steels

Although austenitic steels contain trace amounts of nickel (eight percent) and carbon (0.8 percent), they are high in chromium. In general, austenitic steels have a chromium content of about 18 percent. With applications like the manufacture of pipes, kitchen utensils, and food processing equipment, austenitic steels are the most commonly used type of stainless steel. Even though austenitic steels are not responsive to heat treatments, they are valued for their non-magnetic properties.

 

2. Ferritic steels

Apart from containing trace amounts of nickel, less than 0.1 percent carbon, and about 12-17 percent chromium, ferritic steels usually contain alloy metals like molybdenum, aluminum or titanium in small quantities. Ferritic steels are magnetic, tough, and very strong. However, cold working can be used to strengthen them further. Unfortunately, they are not responsive to heat treatment, meaning no heating technique can be used to harden them.

 

3. Martensitic steels

In addition to containing moderate amounts of carbon (about 1.2 percent) and nickel (less than 0.4 percent), martensitic steels contain 11-17 percent chromium. Aside from having magnetic properties, martensitic steels are also responsive to heat treatments. This type is mainly used to make dental and surgical equipment, blades, knives, and several other cutting tools.

 

Stainless steels have the ability to withstand most of the wear and tear caused by everyday use, making them highly durable. Additionally, an invisible layer of chromium serves to prevent oxidation, making stainless steels resistant to scratches and corrosion.

 

Pros

Stainless steels are generally:

• Low maintenance

• Highly resistant to scratches and corrosion

• Durable

• Hard

• Affordable

 

Cons

• Easy to dent

• The inclusion of nickel raises allergic concerns

• The hardness means limited workability

 

As evidenced by the properties offered by each of the forms, steel has qualities that can meet a broad range of applications. In fact, steel serves an array of construction, appliance, energy transport, and packaging purposes in today's world.

 

Jessica Kane is a professional blogger who writes for Federal Steel Supply, Inc., a leading steel tubing suppliers of carbon, alloy and stainless steel pipe, tubes, fittings and flanges.

Portable Geo Specific Water Filtration Bottle

Students of Indian Institute of Technology Madras Ramesh Kumar and his team member Anupam Chandra won the award appreciation for developing a prototype of Portable Geo Specific Water Filtration Bottle. He carried his project work under guidance of Prof. T. Pradeep.

In all natural calamities, those who get most affected are the poor and affordable solutions are essential for alleviating their sufferings. In regions, such as West-Bengal and Assam where flood water can also contain regional contaminants such as arsenic, rapid removal of particulates, microbial, chemical and regional contaminate such as arsenic and fluoride require a combination of technologies to be effective at acceptable flow rates. A personal water purifier to deliver one liter of clean water from arsenic contaminated water requires materials with enhanced removal kinetics and high adsorption capacity so that filter is effective. This is currently possible only with advanced nano-materials in conjunction with other technologies such as nanofiltration, reverse osmosis, etc. Here it demonstrates an affordable purifier involving multiple technologies for microbially, chemically and heavy metal safe drinking water. In this purifier bottle, feed water passes through four stages of filtration, 1) reusable pre-filter, which removes all particulate matter, 2) microfiltration / ultrafiltration hollow fiber membrane cartridge, which removes all microbial and viral contaminants, 3)geo-specific filtration unit, which removes geo-specific contaminant such as arsenic, fluoride and pesticides, 4)silver nanoparticles decorated activated coconut charcoal, which provides antimicrobial and organic contaminant removal capacity to the water purifier bottle. To develop pressure required in feed water container vessel for microfiltration or ultrafiltration, a hand operable bellow pump is added to the unit. Cheap and indigenously developed filtration membranes make this water purifying device affordable for mass distribution to the affected population of a natural disaster.

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Ramesh Kumar, Department of Nano Science and Engineering,Indian Institute of Technology Madras, with the prestigious Gandhian Young Technological Innovation (GYTI) Award Appreciation at a function held at Rashtrapati Bhawan on March 5.

Design of Highly Efficient and Inexpensive Membrane Equipment as Import Substitutes for Demineralized Water Production and Hemodialysis

Students of CSIR- Indian Institute of Chemical Technology, Hyderabad Harsha Nagar including her team members M. Madhumala, Shaik Nazia, Y.V.L. Ravi Kumar won the award appreciation for developing a Design of Highly Efficient and Inexpensive Membrane Equipment as Import Substitutes for Demineralized Water Production and Hemodialysis. She carried her project under guidence of Dr. S. Sridhar.

Demineralized (DM) water has gained huge applications in various industries including hospitals, laboratory for culture preparation, cooling systems, laser cutting etc. Therefore Membrane Separations Group of IICT has designed a highly compact and low cost two stage cascaded membrane system which would produce 40-60 L/h capacity of demineralized water with a total dissolved solids (TDS) of zero ppm. The system costs Rs. 35000/- only as compared to Rs. 5 – 10 Lakhs charged by multinational companies. The unit produces demineralized water at a cost of 5 Paise per liter with a low maintenance. The another innovation reports the design of low cost spinneret for making synthetic polymeric hollow fibers having different sizes which are used for Dialysis and water purification. The spinneret consist of a bore fluid pin, the lower part of the extruder/polymer solution reservoir which is connected to venturi shape taper with varied diverging part where various concentric polymer clearance can be achieved according to the application. The detachable bore fluid pin mounting design allows hollow fibre with inner diameter ranging from 110 microns to 800 microns. Different sizes of diverging part of venturi shape of taper connected to polymer reservoir allows for the manufacture of hollow fibers having different sizes.

Dr. Francis Gurry Director General of the World Intellectual Property Organization (WIPO) honored Harsha Nagar, CSIR- Indian Institute of Chemical Technology, Hyderabad with the prestigious Gandhian Young Technological Innovation (GYTI) Appreciatipon Award at Rashtrapati Bhavan on 5th March.

A Mechanism for Toilet Seat Sanitation

Students of Indian Institute of Technology, Madras Arvind Pujari and his team members Shashwat Jain, D V S S S Kushal Kumar Reddy, Subham Kumar Sahana and Tanay Garg won the GYTI award appreciation for developing a A Mechanism for Toilet Seat Sanitation.

A simple, purely mechanical device is developed to ensure the sanitation and cleaning of the toilet seat by the push of a foot pedal which can be implemented as an add-on to the existing toilet structure. The mechanism consists of three parts. a) A Lifting Mechanism: A foot pedal lifts the seat, as seen in dustbin lids. b) A Spraying Mechanism: When the seat reaches its apex position, a nozzle is automatically pressed, spraying a sanitizing liquid onto the seat. There are four such nozzles, thus ensuring that the entire seat is sterilized. c) A Wiping Mechanism: The wiper is a rod attached with a removable sponge, located at the back end of the seat, so that it does not encumber the user. When the foot pedal is pressed, the seat is lifted and the wiper is lifted along with the seat until it reaches the front edge, thus cleaning the seat of any dirt or water left by the previous user. Then the spray heads attached to the lid of the seats are pressed and spray a sanitizing liquid on the seat. The spray is uniformly spread and wiped across the seat, by the wiper, thus completely sterilizing it. There are many advantages of this mechanism over currently implemented methods (such as disposable seat covers, sanitary wipes, sanitary sprays and UV light). Thus, this device provides a low cost (the device will cost less that 1000 to manufacture and set up), user friendly, touch free and electricity free method of sanitizing and cleaning the toilet seat by the simple push of a foot pedal.

Dr. Francis Gurry Director General of the World Intellectual Property Organization (WIPO) honored Arvind Pujari, Indian Institute of Technology, Madras, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 Appreciation at Rashtrapati Bhavan on 5th of March.

Grid Interactive Solar PV Based Water Pumping Using BLDC Motor Drive

Rajan Kumar, student of Indian Institute of Technology, Delhi received the Gandhian Young Technological Innovation Award-2017 appreciation for developing a prototype of a Grid Interactive Solar PV Based Water Pumping Using BLDC Motor Drive under the guidance of Prof. Bhim Singh.

Being a grid-isolated or standalone system, the existing brushless DC (BLDC) motor driven water pumps fed by a solar photovoltaic (SPV) array, rely only on solar PV energy. Due to its intermittency, the solar PV generation exhibits its major drawback which results in an unreliable water pumping systems. In the course of bad climatic condition, water pumping is severely interrupted, and the system is underutilized as the pump is not operated at its full capacity. Moreover, an unavailability of sunlight (at night) leads to shutdown of an entire water pumping system. This innovation proposes a bidirectional power flow control of a grid interactive SPV fed water pumping system. A BLDC motor-drive is used to run a water pump. This system and control enable a consumer to operate the water pump at its full capacity for 24-hours regardless of the climatic condition and to feed a single-phase utility grid when the water pumping is not required. The full utilization of SPV array and motor-pump is made possible in addition to an enhanced reliability of the pumping system. Using a single-phase voltage source converter (VSC), a unit vector template (UVT) generation technique accomplishes a bidirectional power flow control between the grid and the DC bus of voltage source inverter (VSI) which feeds a BLDC motor. The maximum power point (MPP) operation of SPV array, and power quality standards such as power factor and total harmonic distortion (THD) of grid are met by this system.

Dr. Prof. K. Vijay Raghavan, Secretary, Department of Biotechnology, honored Rajan Kumar, Department of Electrical, Instrumentation & Related Fields, Indian Institute of Technology, Delhi, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 Appreciation at Rashtrapati Bhavan.

Paper-based device for rapid detection of Dengue

Sanjay Kumar and his team member Pulak Bhushan won the award appreciation for developing a Paper-based device for rapid detection of Dengue. He carried his project work under the guidance of Prof. Shantanu Bhattacharya, Indian Institute of Technology, Kanpur.

Dengue virus is diagnosed using conventional techniques like PCR (polymerase chain reaction) and ELISA (enzyme-linked immunosorbent assay), and even though these methods are highly accurate they need a highly clean lab and expert people to perform these tests. They are also highly expensive and time consuming. The previously developed devices have one major limitation from the commercial point of view. They utilize saliva or serum as their samples. Even though they are an important source of biomarkers and have less interference, they require pre-processing before they can be used. The pre-processing can only be done in a laboratory rendering it useless for developing commercially available lateral flow test strips. Several rapid diagnostic devices are available in the market for detection of dengue. The devices that detect NS1 are only capable of doing so after 3-4 days, since that is when the concentration of Ns1 increases to a considerable amount. Whereas, the devices that can detect IgM and IgG, suffer from the problem that these antibodies are produced in the body only after 4 days and 7 days respectively (primary infection), hence rendering them useless for early detection purposes. The primary objectives of this project are as follows: Development of a device which can detect dengue NS1 in the first 1-2 days itself, when the concentration of NS1 is considerably low. This shall make the device capable of providing an early diagnosis which will further aid the doctors in treating the patients in an effective way. Using whole blood as the sample, eliminating the need of pre-processing which requires external equipment and expertise.

Dr. Francis Gurry Director General of the World Intellectual Property Organization (WIPO) honored Sanjay Kumar and his team member Pulak Bhushan, Indian Institute of Technology, Kanpur, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 Appreciation at Rashtrapati Bhavan on 5th of March.

OCR++: A Robust Framework For Information Extraction From Scholarly Articles

Students of the Indian Institute of Technology, Kharagpur were received the Gandhian Young Technological Innovation Award-2017 for developing a website of OCR++: A Robust Framework For Information Extraction From Scholarly Articles.

Mayank Singh Including his team members Barnopriyo Barua, Priyank Palod, Manvi Garg, Sidhartha Satapathy, Samuel Bushi, Kumar Ayush, Krishna Sai Rohith, Tulasi Gamidi developed this website under guidence of Dr. Pawan Goyal and Dr. Animesh Mukherjee.

This project proposes OCR++, an open-source framework designed for a variety of information extraction tasks from scholarly articles including metadata (title, author names, affiliation and email), structure (section headings and body text, table and figure headings, URLs and footnotes) and bibliography (citation instances and references). A diverse set of scientific articles written in English to understand generic writing patterns and formulate rules to develop this hybrid framework is analysed. Extensive evaluations show that the proposed framework outperforms the existing state-of-the-art tools by a large margin in structural information extraction along with improved performance in metadata and bibliography extraction tasks, both in terms of accuracy (50% improvement) and processing time (52% improvement). A user experience study conducted with the help of 30 researchers reveals that the researchers found it to be very helpful.

For this project Prof. Anil K Gupta Co-ordinator, SRISTI and Founder, Honey Bee Network, honored Mayank Singh and his team members Barnopriyo Barua, Priyank Palod, Manvi Garg, Sidhartha Satapathy, Samuel Bushi, Kumar Ayush, Krishna Sai Rohith, Tulasi Gamidi, Indian Institute of Technology, Kharagpur, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

Fish-Inspired Propulsion System for Remotely Operated Surface Ships and Underwater Vehicles

Mannam Naga Praveen Babu won the award for the research project ‘Fish-Inspired Propulsion System for Remotely Operated Surface Ships and Underwater Vehicles’. He carried his research work under the guidance of Prof. Krishnankutty P. Department of Naval Engineering, Indian Institute of Technology Madras, Chennai.

The Autonomous Marine Vehicles (AMVs) are much in use for exploring subsea natural resources, monitoring marine pollution, performing hydrographic surveys, etc. Energy for AMV operations are taken from battery cells provided inside the AMV. The energy consumption can be reduced by providing the AMVs with a propulsion system which is more efficient than the conventional screw type thrusters. Recent advances in planetary sciences shows that NASA is trying to explore liquid atmospheres such as methane lakes, icy crust atmospheres in Jupiter's largest moon Europa and Titan planets with the help of robotic eel fish and underwater submarines. The use of marine vehicles on earth ocean's world exploration advances into planetary atmospheres. Compared to conventional marine vehicles, bio-inspired swimming vehicles have shown higher performance in comparison to screw propellers. This performance results in efficient cruising, maneuverability (turning and stopping ability), noiseless motion and eco-friendly. These are defined as fish-like bio-inspired vehicles which propel through undulation or oscillation motion of the fish body or its fins. Flapping foil propulsion are more efficient (80%) than the conventional screw propulsion system (60%). Use of flapping foils also disturbs the water less compared to screw propellers, thus making it more environment friendly and create less noise. With these perspectives under consideration, the present research reports the studies carried out on a remotely operated surface ship model and underwater vehicle fitted with a fin at the aft end, resembling caudal fin of a thunniform fish. The aft (tail) fin has freedom to oscillate in the horizontal plane about the longitudinal axis. Self-propulsion tests are carried out for determining the thrust performance of marine vehicles

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Mannam Naga Praveen Babu, Department of Naval Engineering, Indian Institute of Technology Madras, Chennai with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017  at Rashtrapati Bhavan.

Never Ending Learning Of Sound

Ankit Shah including his team members Rohan Badlani, Benjamin Elizalde, Anurag Kumar National Institute of Technology, Surathkal received the Gandhian Young Technological Innovation Award-2017 for developing an application on Never Ending Learning Of Sound. He carried his project under guidance of Prof. Bhiksha Raj.

Sound recognition is critical to the development of artificial intelligence. However, sound recognition remains an arcane task for computers, given the incomplete understanding of how humans are able to recognize sound and understand its meaning naturally. Never Ending Learning of Sound (NELS) is a system that will continuously learn about sounds through direct supervision or automatically, and expand its vocabulary of sounds through analysis of audio and multimedia recordings and thei r corresponding metadata. It will eventually present a comprehensive repository of sounds – an invaluable resource in many fields – ranging from automatic video content analysis to audio forensics. India is on its path to a digital transformation, and a semantic understanding of sounds from NELS will help create smarter cities, robotics, automated surveillance systems and will also redefine tangible experiences for approximately 60 million deaf people in India. NELS will identify known sounds and detect the occurrence of new. Then, learn to recognize new sounds and associate their semantics and metadata to increase its vocabulary. It will also learn hierarchies in the structure of sounds, learn physical and common-sense structural and temporal relationships between sounds, and associations between sounds, their meaning and semantics and categories. NELS system will provide the largest and most up-to-date available repository of sounds in the world.

Dr. Francis Gurry, Director General of the World Intellectual Property Organization (WIPO), honored Ankit Shah and his team from Department of Computer science, Information technology & related fields, National Institute of Technology Surathkal, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017  at a function held at Rashtrapati Bhavan on March 5.

Blood Quality Assessment using Digital Holographic Microscopy

Mandeep Singh including his team member Azhar Muneer won the award for the research project Blood Quality Assessment using Digital Holographic Microscopy. He carried his research work under the guidance of Dr. Kedar Khare and Dr. Sarita Ahlawat Indian Institute of Technology, Delhi.

The stored blood in blood banks is used regularly in surgical procedures or transfusions. Blood quality assessment is therefore an important routine task. Current blood quality assessment protocols involve a number of chemical assays or impedance measurements making the process cumbersome and difficult to standardize. In recent years IIT Delhi has developed and patented a superior DHM technology for accurate high resolution 3D imaging of biological cells for blood cell classification and quality assessment. DHM operates on the principle of interference of light and can provide accurate information regarding minute refractive index changes in the cells that are ultimately related to cellular changes in response to ageing, physical cell damage or infections. Using the novel 3D imaging capability of this prototype system has indicated that fresh and old red blood cells have clearly distinguishable morphological features.

Mandeep SinghThe specialty of the DHM technology is that the usual wet-lab processing of cells prior to their analysis can be minimized thus significantly reducing recurring costs for chemical reagents. With a more systematic effort in this direction the aim is to develop a methodology for blood cell classification and quality testing that can benefit large number of hospitals, blood banks and pathology labs across India and beyond. The work is expected to lead to an early application of an indigenously developed microscopy technology with superior imaging performance.

Dr. Renu Swarup Senior Advisor, DBT and MD, BIRAC honored Mandeep Singh and Azhar Muneer with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

Enhancement of Distribution System Performance using High Voltage Alternating Current (HVAC) Boost Converter and Fuzzy Controller

Anusha Vadde Student of the M. S. Ramaiah University of Applied Sciences, Bengaluru received the Gandhian Young Technological Innovation Award-2017 for developing a prototype Enhancement of Distribution System Performance using High Voltage Alternating Current (HVAC) Boost Converter and Fuzzy Controller. She carried her project under guidance of  V. S. N. Sitaramgupta V.

Power quality is one of the key factor in electrical systems and is taken into consideration to meet the demands of the customer. Voltage dips, momentary interruptions, harmonics and transient surges affect the reliability and quality of the power supply. The reliability and cost of any electrical system depends on the quality of the supplied power and consumed by the system. High Voltage Distribution System (HVDS) is one of the methods used to improve the quality and reliability of the distribution system through a reduction in losses, voltage fluctuations and power consumption. In HVDS, power is transmitted from the distribution station to consumer premises through the booster transformers and voltage regulators. Inrush currents or magnetizing currents and heating of insulation have been observed in transformers due to non-linear loads. As a result, the current drawn by the system is high. To overcome these effects, a step-up power converter with fuzzy controller has been designed. In this research work, High Voltage Alternating Current (HVAC) Boost Converter with fuzzy controller has been proposed for a costeffective solution to reduce distribution losses. Simulation studies have been carried out for verifying the utilities of the proposed design. The performance of the designed fuzzy logic controller is compared with that of the existing booster transformer scheme by using the simulations. It has been found that the efficiency is improved by 4%, and power losses are reduced by 1.4% to maintain the voltage fluctuations within the acceptable levels. The proposed controller in the case study of old city area in Hyderabad has been shown that revenue savings are increased by 12%.

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Anusha Vadde, Department of Electrical, Instrumentation & Related Fields, M. S. Ramaiah University of Applied Sciences, Bengaluru with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017  at a function held at Rashtrapati Bhavan on March 5.

Affordable Paper Microfluidic Device for Blood Glucose and Cholesterol Detection

Avisek Barla and his team members Abrar Ali Khan, Sameer Sharma, Vijay Anand, Nitish Kumar Singh  won the award for the research project Affordable Paper Microfluidic Device for Blood Glucose and Cholesterol Detection. He carried his research work under the guidance of Dr. Vignesh Muthuvijayan, Indian Institute of Technology, Madras.

Non-communicable diseases (NCDs) can easily be held responsible for majority of the deaths worldwide and India is no exception. The work is done on detecting diabetes, cholesterol and predict its cumulative effect. There are specific cases of brain stroke leading to complete or partial paralysis including severe cognitive impairment in the long term. The huge demand for diagnosis has flooded market with Point of Care devices for diabetes, but not yet for cholesterol. The cost of an average device is Rs 800-1500 in the market, but in this project, the price point of the strips used is around Rs 15-50. Thus, a lowcost paper based sensor meant for the masses is made. One would require to add a few drops of blood to the device and colour change will happen in the specified region. A camera is used to quantify and measure colour to display the concentration. The data collected will be used to map the prevalence of the disease and predict the occurrence of strokes. The work is in the process of making a blood drawing mechanism and plasma separation unit which will complete the picture of a true consumer device at nominal price.

Dr. Prof. K. Vijay Raghavan, Secretary, Department of Biotechnology, honored Avisek Barla, research scholar,  Indian Institute of Technology, Madras, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 Appreciation at Rashtrapati Bhavan.

IIT-M scholar wins GYTI 2017 Award ~ telanganatoday.news

Students and Research Scholars of Indian Institute of Technology (IIT-Madras (Madras have won several laurels at Gandhian Young Technological Innovation (GYTI) Awards 2017.

IIT-M scholar wins GYTI 2017 Award

Chennai: Students and Research Scholars of Indian Institute of Technology (IIT-Madras (Madras have won several laurels at Gandhian Young Technological Innovation (GYTI) Awards 2017.

Dr Vikram Singh, former Research Scholar in the Department of Chemistry, IIT Madras, won the BIRAC GYTI Award for his project ‘White Light Emission from Vegetable Extracts’ (http://gyti.techpedia.in/project-detail/white-light-emission-from-vegetable-extracts/7414). He was guided by Prof. Ashok Kumar Mishra, Professor, Department of Chemistry, IIT Madras.

Prof. Ashok Kumar Mishra, Department of Chemistry, explains, “Plants are rich sources of many classes of molecules that absorb light and emit in the visible wavelength ranges. Our reported work shows that judicious choice of such molecules can provide cheap and environment-friendly sources of white light emission systems. This is essentially a ‘proof of concept’ work and further research is necessary to address the issues of molecular/material stability and device compatibility”.

Dr Vikram Singh says, “Receiving the prestigious GYTI Award at Rastrapati Bhawan was a big honour for me and I am delighted. I will be using the Rs 15 lakh award grant to continue my research on white light emitting material from plant sources. I plan to research on RGB Emitting Carbon Quantum Dots from Vegetables/Fruits extract”.

The BIRAC-SRISTI award for biotechnological/medical/healthcare innovation is given to a technology having the potential to reach the masses and/or address a felt social need or making it extremely affordable compared to the available solution. Up to fifteen of the selected innovations may be given a grant of Rs.15 lakh each and another hundred ideas may be granted Rs 1 lakh each for taking the idea forward.

Several students also won GYTI appreciation awards.

They include:
• Anupam Chandra and Ramesh Kumar (Project Associate) for their project entitled Portable Geo-specific Water Filtration Bottle. They were guided by Prof. T Pradeep.

• Arvind Pujari, Tanay Garg, Shashwat Jain, Kushal Kumar Reddy DVSS and Subham K Sahana for their project entitled A Mechanism for Toilet Seat Sanitation. They were guided by Prof. Anil Prabhakar.

• Avisek Barla, Abrar Ali Khan, Sameer Sharma, Vijay Anand and Nitish Kumar Singh for their project entitledAffordable Paper Microfluidic Device for Blood Glucose and Cholesterol Detection. They were guided by Dr Vignesh Muthuvijayan.

• Mallikarjunachari G for his project entitled Design of a Mechanical Device (Nanorobot) for Diagnosis and Removal of Plaque from Human Heart Artery System. He was guided by Dr Pijush Ghosh.

• Mannam Naga Praveen Babu for his project entitled Fish-Inspired Propulsion for Remotely Operated Surfaces Ships and Underwater Vehicles. He was guided by Prof. P Krishnankutty.
The GYTI Awards celebrate the spirit of student innovation in all the fields of engineering, science, technology and design through extremely affordable/frugal solution or the ones pushing the technological edge. These could deal for example, with a) communities at grassroots, b) co-creation with grassroots innovators, c) ‘manufacturable’ technologies for saving or generating energy, sanitation, water purification, saving material consumption, d) biotechnology and medical devices, e) diagnostics, f) assistive devices for physically challenged, and all others areas of social and industrial applications.

One can submit more than one application in hardcore manufacturing areas, including but not restricted to aerospace, transportation, construction, textile, electronics, nanotechnologies, computer science applications etc.

The SRISTI (Society for Research and Initiatives for Sustainable Technologies and Institutions) instituted the awards to encourage innovative student projects in engineering, pharmacy, science and other applied technologies. They are given every year during the Festival of Innovation (FOIN) at Rashtrapati Bhawan in March.

For any query, contact Team Techpedia-GYTI at gyti.techpedia@sristi.org, contact no: +919099258492. For looking at the awards given this year, please visit www.techpedia.in, www.sristi.org initiative.

 

By   |   Published: 27th Apr 2017  2:24 pm

Indigenous Technology of Soft Body Armour for Defence Applications Using 3D Woven Aramid Fabrics

Animesh Laha, Student of the Indian Institute of Technology, Delhi received the Gandhian Young Technological Innovation Award-2017 for developing a prototype of Indigenous Technology of Soft Body Armour for Defence Applications Using 3D Woven Aramid Fabrics. He carried his project under guidance of Dr. Abhijit Majumdar. 

Soft body armours are developed by using multiple layers of high performance fabrics. Generally, 30-40 layers of 2D fabrics woven aramid fabrics (Kevlar, Technora etc.) or ultrahigh molecular weight polyethylene (UHMWPE) sheets are assembled together to make soft armour panel which becomes heavy and inflexible. In this innovation, two approaches have been amalgamated to reduce the weight of body armour. 3D fabrics, in which yarns are arranged in three perpendicular directions, namely X, Y and Z were produced in the laboratory. 3D fabrics were then treated with shear thickening fluid (STF).

STF treated 3D fabric prototypes developed in this research have been tested against 9 × 19 mm bullets (430 m/s). Soft armour panel having STF treated 3D fabrics stopped bullets fired at 430 m/s. The areal density of the panels was 4500 g/m square. Moreover, the depth of back face signature for these fabrics was varying from 31 to 39 mm which is within the acceptable limit (44 mm). The panel containing STF treated 3D fabric showed dome formation, crack generation and fibre breakage to a lesser extent as compared to those of fabric panels containing untreated 3D fabrics.

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Animesh Laha, Department of Textile, Indian Institute of Technology, Delhi, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017  at a function held at Rashtrapati Bhavan on March 5.

Swayam- Passively Stabilized Communication Satellite

The COEP Satellite Initiative team from College of Engineering, Pune received the award for the project 'Swayam- Passively Stabilized Communication Satellite'. They carried their project work under the guidance of Dr. M. Y. Khaladkar and Dr. B. B. Ahuja.

Swayam is a pico-satellite developed by undergraduate students of College of Engineering, Pune. Swayam is a passively stabilized communication satellite of dimensions 10 X 10 X 11.35 cm and mass 990 g. Swayam was launched by ISRO on 22nd June, 2016 by PSLVC34. Swayam is currently in-orbit and data is being downlinked at COEP ground station and analysed on a regular basis. Student satellites offer a distinct challenge in terms of reliability and interdisciplinary nature of design. To achieve the highest standards of design and fabrication, the project was organized into five constituent subsystems. Attitude control is achieved by a passive magnetic attitude control system to satisfy the space and energy constraints. This system consists of an orthogonal arrangement of magnet and hysteresis rods. Volume, strength and placement of magnetic materials are the major design considerations. A numerical simulation has been developed to conclude the effect of various design parameters on stabilization time and its feasibility for the communication payload. Swayam has a half-duplex communication subsystem. Beam of the antenna is optimized to offer maximum communication link time in conjunction with the available pointing accuracy. To satisfy the power budget of the satellite, the autonomously sent beacon is sent at lesser power than the digital payload data. The power subsystem of the satellite is fully analog capable of functioning independently. Swayam as a template is ideal for carrying low profile payloads which do not require magnetically clean environment. Swayam is also an experiment which shows the cohesive application of passive stabilization for a communication satellite in low power environment.

For this innovation Dr. Anil Sahasrabudhe, Chairman of the All India Council for Technical Education, honored team COEP Satellite Initiative, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

A Novel Bio-engineering Approach to Generate an Eminent Surface Functionalized Template for the Selective Detection of Female Sex Pheromone of Certain Agriculturally Hazardous

Dr. Parikshit Moitra and Dr. Deepa Bhagat from Indian Institute of Science, Bengaluru were given the Gandhian Young Technological Innovation Award-2017 for developing a prototype of A Novel Bio-engineering Approach to Generate an Eminent Surface Functionalized Template for the Selective Detection of Female Sex Pheromone of Certain Agriculturally Hazardous under guidancep of Prof. Santanu Bhattacharya.

Plant pests exert serious effects on food production due to which the global crop yields are reduced by ~20-40% per year, as estimated by FAO. Hence to meet the world's food needs, loses of food due to crop pestsmust be reduced. Herein silicon dioxide or zinc oxide based MEMS devices are covalently functionalized for robust and efficient optical sensing of the female sex pheromones of the pests like Helicoverpa armigera, Scirpophaga incertulas and Bactocera oleae for the first time in literature.A Novel Bio-engineering Approach to Generate an Eminent Surface Functionalized Template for the Selective Detection of Female Sex Pheromone of Certain Agriculturally Hazardous

The relative sensitivity of the functionalized MEMS devices is improved by the variation in functionalization protocols that either increased the number of amine or β-cyclodextrin functionalities on each anchor site. The functionalized devices are also capable of selectively measur ing the concentration of this pheromone at the femtogram level which is much below the concentration of pheromone found at the time of pest infestation in an agricultural field. Again, the reversible use of the functionalized devices in any season under ambient conditions, photochemical and thermal stability of the devi c e s and absolut e ly t roubl e f r e e transportation of these pheromone nanosensors heightens their potentials for commercial use. Overall, a novel and unique approach is reported herein for the selective and reversible sensing of female sex pheromones of certain hazardous pests which may be efficiently and economically carried forward from the research laboratory to the agricultural field to determine the stage of prior pest infestation. Necessary actions can then be taken as and when necessary in a confined region of alerted pest attack.

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Dr. Parikshit Moitra, Department of Agricultural Engineering, Indian Institute of Science, Bengaluru, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhawan on March 5.

Navyo – The Smart Glove

Madhav Aggarwal, Mohd. Suhail and Bhavesh Pachnanda, Students of the Delhi Technological University, Delhi were given the Gandhian Young Technological Innovation Award-2017 for developing a prototype of a Navyo – The Smart Glove under guidance of  Dr. Vikas Rastogi.

In the midst of the fast paced life and era of technology, a blind person is still in state of confusion that how will he/she manage to reach his/her destination. Due to his/her impairment, he/she is unable to find his direction (i.e. from where to take a left or a right turn) and eventually gets lost every now and then. So, another person becomes necessary for guiding him along the path. This makes him/her highly dependent on others for his mobility.

Navyo the smart gloveWith this, not only does he reduce his productivity but also, loses his freedom and confidence to walk alone. So, to cater the aforementioned problem a smart glove that will guide the person turn by turn to reach the destination via vibrations is created. Navyo is accompanied by a mobile App, interface of which is simple and easy to use. User simply needs to speak out the destination in App. Navyo then connects to app via Bluetooth and the person is ready to go. As per the map, when the left turn approaches, the frequency of vibration also starts increasing in left portion of hand indicating left turn and stops when turn is taken. This way by following different vibration patterns at different maneuver points (i.e. right turn, overhead bridges, underpass etc) destination can be reached out easily. In case, user has missed out any vibration instruction on glove, then it can be repeated by simply pressing a button on Navyo. The solution is based on haptic feedback technology which is safe and non-distractive from blind person's point of view. Also, this solution provides the hassle-free way for navigation by allowing user to speak the destination and walk with mobile phone inside pocket/purse etc.

Dr. Francis Gurry Director General of the World Intellectual Property Organization (WIPO) honored Madhav Aggarwal, Department of Electronics, Communications & related fields, Delhi Technological University, Delhi, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhawan on March 5.

 

Non-invasive, Point-of-care Diagnostic System for Early Detection of Oral Cancer using Digital Infrared Thermal Imaging

Manashi Chakraborty, Dr. Santanu Patsa and Dr. Nishat Anjum received the award for the research project Non-invasive, Point-of-care Diagnostic System for Early Detection of Oral Cancer using Digital Infrared Thermal Imaging. She carried her research work under the guidance of  Dr. Sudipa Mukhopadhyay, Indian Institute of Technology, Kharagpur.

This project is the pioneering attempt to develop a non-invasive, non-ionizing, radiation hazard free, point-of-care computer aided diagnostic framework for oral cancer detection using machine intelligence and Digital Infrared Thermal Imaging (DITI). Oral cancer is the most common cancer in India where approximately 14 people die/hour. Patients are unable to avail diagnosis due to scarcity of state-of-the-art infrastructure and oral-pathologist. Patients are reluctant to go for invasive biopsy. All these along with absence of screening facility pose hindrance to early diagnosis. Due to abnormal metabolic activities in carcinogenic facial regions, heat signatures of patients are different from that of normal subjects. Asymmetry of temperature distribution was compared between facial regions (opposite sides of frontal image and between left and right profile images) for patients and normal subjects.

Disparity_AnalysisThe analysis suggested that patients manifest greater asymmetry compared to normal subjects. This project requires only a one-time investment of a long infrared thermal camera, image processing and machine learning software and a laptop/workstation. Thus, there is minimal resource requirement. Also, Digital Infrared Thermal Imaging (DITI) has no recurring or maintenance cost. The image acquisition protocol is so simple that even a high school student can acquire the images. It provides on-spot oralcancer screening facility and is portable. Thus, screening camps can be organised even in remote villages with minimal infrastructure. As DITI has no recurring cost, it can be scaled up to cater the huge population of developing countries like India.

Dr. Prof. K. Vijay Raghavan Secretary, Department of Biotechnology, honored Manashi Chakraborty, Department of Medical Science & Technology, Indian Institute of Technology, Madras, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhavan on March 5.

 

Affordable detection kit for Cervical Cancer

Appidi Tejaswini, Syed Basseruddin Alvi , Anurag Meena Students of the Indian Institute of Technology, Hyderabad were given the BIRAC-SRISTI Gandhian Young Technological Innovation Award-2017 for developing a prototype of an Affordable detection kit for Cervical Cancer under guidance Dr. Aravind Kumar Rengan.

Cervical cancer is treatable, if diagnosed early. The screening/diagnostic procedures available are time-consuming and explorative. A system which is simple, economical with immediate results is needed to increase frequency of screening. The innovation has paved way for the development of one such system.

Strip based device for detetcion(2)A technique is developed to quantify the acetic acid that is used for protein coagulation which is responsible for the aceto-white patches in VIA [Visual Inspection with Acetic acid, a conventional screening procedure for detection of Cervical cancer/Cervical intraepithelial neoplasia (CIN)]. The percentage of acetic acid is quantified; such that various percentages would result in various colors. This will help to identify the presence of cervical cancer/CIN without naked eye observation as required in VIA. This technique will be embedded into a paper/strip based device which can be initially used as an assistive technique but has the capability to emerge as self-screening tool. A qualitative screening procedure VIA is also quantified which can be easily embedded into paper/strip based device for the development of an economical, easy to handle kit which will increase the frequency and improve the ease of screening which would in turn increase the Cervical cancer survival rate.

For this innovation Dr. Renu Swarup Senior Advisor, DBT and MD, BIRAC, honored Appidi Tejaswini, Department of Nano Science and Engineering, Indian Institute of Technology, Hyderabad, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan on March 5.

 

Portable Biosensing Platform Based on Conducting Polymer Decorated Optical Fiber for Bacteria as well as Heavy Metal Sensing in Tap Water

Sutapa Chandra, Rosna Binish, Arvind Dhawangale students of the Indian Institute of Technology, Bombay were given the BIRAC-SRISTI Gandhian Young Technological Innovation Award-2017 for developing a prototype of a Portable Biosensing Platform Based on Conducting Polymer Decorated Optical Fiber for Bacteria as well as Heavy Metal Sensing in Tap Water under guidance of Prof. Soumyo Mukherji.

The presence of water borne bacteria and heavy metals in tap water could be a potential human health risk and may lead to death of young children and adult. To address this issue, a common platform is developed for detection of water contaminants (bacteria and heavy metals) in tap water. The primary sensing mechanism is based on change of optical properties of polyaniline (conducting polymer) due to the binding of water contaminants on the polyaniline coated fiberoptic sensor probe. The experimental setup consists of a broadband light source, light focusing optics and fiber-optic spectrometer. Depending on the analyte (heavy metals, bacteria etc.), polyaniline coated optical fibers were functionalized with different receptors. Thus, by changing the surface chemistry of the polyaniline coated sensor probe, it can be made specific towards detection of different analyte. As a proof of concept, it is demonstrated that as low as 20- 60 cfu/ml concentrations of E. coli and 1 picomolar concentration of lead ions are detectable using this system.

sutapa chandraThe deliverable will be a marketable prototype of an optical fiber sensor integrated with microcontroller unit. The novelty lies in the alteration of optical properties of polyaniline and its utilisation for water contaminants sensing. The detection limit aimed by this technology will surpass the conventional methods available for detecting these analytes. The sensitivity and specificity available by this technology ensures its applicability in water industry.

For this innovation Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Sutapa Chandra, Department of Bioengineering, Indian Institute of Technology, Bombay, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan on March 5.

Affordable and Rapid Paper-based Test Kits for Antimicrobial Susceptibility Assays

Students of the Indian Institute of Technology, Kharagpur were received the BIRAC-SRISTI Gandhian Young Technological Innovation Award-2017 for developing an Affordable and Rapid Paper-based Test Kits for Antimicrobial Susceptibility Assays.

Shantimoy Kar including team members Tarun Agarwal, Shubhanath Behera, Varun Varma developed this test kit under guidence of Dr. Suman Chakraborty and Prof. Tapas K. Maiti. At the present scenario, increasing drug resistance of the pathogenic microbes is a global threat to the human mortality. To meet this challenge, there is a need to develop a rapid antimicrobial susceptibility testing platform. The cur rent methodologies for detec ting antimicrobial susceptibility suffer from severe limitations, thereby negatively effecting patient's survival rates. These techniques are time consuming, labor intensive, require sophisticated infrastructures and skilled personnel; which collectively increase overall cost of the diagnosis. In this context, herein, a simple paper based microfluidics platform for easy and rapid execution of antimicrobial susceptibility assays is developed.

Device schematicsThe device consists of a paper-based platform which includes four different layers: a base layer, a bacterial suspension layer, a drug layer and a top layer containing a chromogenic substrate which changes color in accordance to the bacterial metabolic activities. The developed technology provides faster detection (~ 5-6 h) and multiplexing (upto 8 different samples could be analyzed) in comparison to the gold-standard stereotype laboratory practices. Moreover, portable nature and ease of fabrication method collectively make it more convenient for functioning at resource limited settings.

For this innovation Prof. Anil K Gupta Co-ordinator, SRISTI and Founder, Honey Bee Network, honored Shantimoy Kar and team Tarun Agarwal, Shubhanath Behera, Varun Varma, Department of Applied Technology, Indian Institute of Technology, Kharagpur, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

Carbon Zero Challenge

The Carbon Zero Challenge is a pioneering initiative by IIT Madras and IWMA in collaboration with the US Consulate General, Chennai. CZEROC seeks innovative ideas and proof-of-concept solutions from students and entrepreneurs in Tamil Nadu, Kerala, Karnataka, Puducherry, and the Andaman and Nicobar Islands.

 

NeuroBuds: Brain Wave Mapping Smart Earphones for Rural India

Nitin Vasanth, student of the Cochin University of Science & Technology, Cochin received the BIRAC – SRISTI Gandhian Young Technological Innovation Award-2017 for developing a prototype of a NeuroBuds: Brain Wave Mapping Smart Earphones for Rural India under the guidance of Prof. Unni A M.

NeuroBuds PrototypeAn average human brain consists of over 80 billion neurons. These communicate with each other by sending short ionic impulses, which in turn creates small voltage fluctuations around the proximity of brain. By placing highly sensitive sensors, these fluctuations can be used to understand the brain activity. NeuroBuds is a pair of smart earphones that have these specially fabricated sensors embedded into it to understand the brain activity of user. These sensors are integrated into the architecture of an earphone along with a pre-processor. The data from the sensor is passed on to the Smartphone from where the rest of processing is done. This way of utilization of smartphone processor and smartphone battery to power NeuroBuds reduces the requirement for dedicated on-board processor and battery module reducing the size of device greatly. More importantly this helps reduce the device cost to a price point that makes it accessible to common man who is usually unable to explore other expensive brain activity solutions that exist now. The brain data is analysed to look for anomalies in pattern that indicate brain disorders like Epileptic seizures. This kind of early detection helps in doing pre-emptive action and sending out alerts/SOS. The brain wave data is also used to analyse the mental state of the user, their concentration levels and stress levels. At a time when the working population suffers from stress related issues and sleeping disorders due to a fastpaced lifestyle, NeuroBuds can be used as a mental health monitor. Once the application has enough data coming in from different users, it can recognize patterns and optimize algorithms on its own using the underlying neural network. NeuroBuds serves as the perfect link between the user and the smartphone to monitor other body vitals including heartbeat.

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Nitin Vasanth, Department of Biomedical Engineering, Cochin University of Science & Technology, Cochin, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

Design & Development of Automated Five Axis CNC Ball End Magnetorheological Finishing Machine

Dilshad Ahmad Khan and his team member Faiz Iqbal, Zafar Alam won the Appreciation award for the project Design & Development of Automated Five Axis CNC Ball End Magnetorheological Finishing Machine. He carried his project work under the guidance of Dr. Sunil Jha, Indian Institute of Technology, Delhi.

The project is an innovation and technology based work aimed at providing nano level finish on various materials of complex shapes and size. This project is related to the design and development of a fully automated five axis CNC ball end magnetorheological finishing (BEMRF) setup from the conceptual idea to an industry standard machine. The developed machine caters to the demand of today's advanced industries which deals in finishing of 3-D dies, high precision lenses, orthopaedic implants, jewelleries and gems etc. In the first phase of the project an idea is conceptualized to finish 3-D complex surfaces using magnetorheological polishing (MRP) fluid. After checking the feasibility of the concept, a BEMRF tool is developed which is later mounted on a CNC machine setup. The newly developed finishing process is used to finish ferromagnetic as well as nonmagnetic materials of complex shapes and sizes using specially prepared magnetorheological polishing fluid. Apart from nano finishing on the surfaces, the measurement of surface roughness of the workpiece is also needed to be wear free which is not the case in stylus based measurement systems. Therefore, a non-contact roughness measurement instrument (confocal sensor) is incorporated in BEMRF machine. The confocal sensor is light, compact and easily mounted on the BEMRF tool for quick and error free measurement of surface roughness after the BEMRF process. In BEMRF machine the forces can be controlled automatically thereby enabling the user to select suitable force according to the material to be finished.

Anil Sahasrabudhe, Chairman of the All India Council for Technical Education, honored Dilshad Ahmad Khan, research scholar, Indian Institute of Technology, Delhi, with the prestigious Gandhian Young Technological Innovation (GYTI) Appreciation award 2017  at Rashtrapati Bhavan.

 

Low Cost Automated Handheld Melamine Detection Device (for Testing Melamine in Milk)

Students of the Indian Institute of Science, Bangalore Dhiraj Indana including his team member S.C.G. Kiruba Daniel, Varun S, Prateek Katare who worked under the guidance of Dr. Sai Siva Gorthi received the Gandhian Young Technological Innovation Award-2017 for developing a prototype of a Low Cost Automated Handheld Melamine Detection Device (for Testing Melamine in Milk).

Device_PhotoEven though a number of kits and devices are available for detecting common milk adulterants like urea, boric acid, water, sugar and detergents, there is hardly any portable device available for the detection of melamine. Till now, bulky instruments like Gas Chromatography (GC), HPLC, GC-MS and LC-MS are being used for detecting melamine which costs between 25 to 50 lakhs rupees, as well as requiring skilled personnel for operation. A fully automated handheld device to detect melamine from milk with integrated milk pre-processing step done using chemical dried cotton is developed. Melamine is finally detected through interference in Silver nanoparticle formation. Both the preprocessing and detection steps are innovative and patented. The cost of the device may be few thousand rupees which is almost 1000 times lesser than the price of existing conventional instruments. The developed device is user-friendly Low Cost Automated Handheld Melamine Detection Device (for Testing Melamine in Milk) which can give the level of melamine adulteration in ppm directly. Thus, the device not only tells the user whether the milk is fit for consumption or not but also gives the exact concentration of melamine in milk. This device fulfills the goal of taking melamine sensing to every household so as to protect every person from melamine adulteration.

For this innovation Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Dhiraj Indana, Department of Nano Science and Engineering, Indian Institute of Science, Bangalore, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhawan on March 5.

Near Infrared Fluorescence Probes for Diagnosis of Alzheimer’s disease

K. Rajasekhar and Kavita Shah received the award for the research project Near Infrared Fluorescence Probes for Diagnosis of Alzheimer's disease. He carried his research work under the guidance of Prof. T. Govindaraju, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru at a function held at Rashtrapati Bhawan on March 5.

K. RajasekharSelective detection and staining of toxic amyloid beta (Aβ) plaques found in the Alzheimer's disease (AD) brain is crucial for clinical diagnosis and monitoring of the disease progress. Herein, a coumarin-quinoline (CQ) conjugate-based molecular rotor type, turn-on near-infrared (NIR) fluorescence probe for selective and specific detection of Aβ fibrillar aggregates is designed. The probe CQ selectively binds to Aβ fibrillar aggregates over other toxic protein aggregates such as Tau, α-synuclein (α-Syn) and islet amyloid polypeptide (IAPP), and exhibit ~100 fold fluorescence enhancement with nanomolar binding affinity (82 nM). CQ effectively displace Thioflavin T bound to Aβ fibrillar aggregates and exhibit multiple binding sites on Aβ fibrillar aggregates which is extensively studied through fluorescence resonance energy transfer (FRET) and molecular docking. Remarkably, CQ unambiguously stains Aβ plaques in human brain tissue over its co-existing Tau aggregates, neurofibrillary tangles (NFTs), which are strongly associated in AD and in various tauopathies. This is a highly desirable attribute to distinguish AD from disease conditions caused by Tau pathology.

Dr. Francis Gurry Director General of the World Intellectual Property Organization (WIPO) honored K. Rajasekhar, Department Biological Sciences, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.​

Prophylactic Transdermal Patch Against Neurotoxin Poisoning In Biological Warfare Situations

Subham Banerjee won the award for the research project Prophylactic Transdermal Patch Against Neurotoxin Poisoning In Biological Warfare Situations. He carried her research work under the guidance of Dr. Pronobesh Chattopadhyay, Dr. Animesh Ghosh Defence Research Laboratory, Tezpur Birla Institute of Technology, Mesra.

Drug-in-adhesive matrix type combinational prophylactic transdermal patch composed of eserine and pralidoxime chloride (PAM) against acetyl choline agonist (±)-anatoxin a neurotoxin poisoning was developed. Initially, a simple RPHPLC method was developed and validated for the s imult aneous de t e rmina tion and quantification of eserine and 2-PAM using UV detection. The method was validated as per ICH guidelines for validation of analytical procedures, and was applied for the routine analysis of these two drugs in fabricated transdermal patches.

Product DesignAdhesive matrix type transdermal patches containing eserine and 2-PAM were prepared by solvent casting method. The drug combinations were incorporated in adhesive matrix type system supported by a polyester film laminate backing membrane and attached to a temporary releaseliner. The dermal patches were having desired properties such as thin, circular, opaque, smooth, homogeneous, sticky, uniform, flat and flexible in nature. The drug release was sustained from all the formulations up to 72 h and following anomalous (non-fickian) diffusion and fickian release mechanism for eserine and 2-PAM, respectively. Optimized transdermal patch exhibited highest acceptable levels of tackiness with good adherence capacity and showed promising stability potential with respect to all points of analysis. From safety point of view, the optimized transdermal patch was safe for application to the skin with no dermal and mutagenic toxicity as well. Pharmacodynamic study proved that the optimized transdermal patch was effective against acetyl choline agonist (±)-anatoxin a neurotoxin poisoning. While pharmacokinetic study revealed that the systemic absorption of the drugs from the fabricated best optimized patch through the skin was sufficient enough to achieve pharmacodynamic efficacy.

Dr. Prof. K. Vijay Raghavan Secretary, Department of Biotechnology honored Subham Banerjee, Defence Research Laboratory, Tezpur Birla Institute of Technology, Mesra, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

STERI-FREEZ: Flash Freeze Sterilization

Saugandha Das including her team member Archit Devarajan won the award for the research project STERI-FREEZ: Flash Freeze Sterilization. She carried her research work under the guidance of Prof. Padma V. Devarajan Institute of Chemical Technology, Mumbai.

STERI-FREEZ_IMAGE 1Surgical site infections are one of the most common complications associated with surgery, with reported incidence rates of 2-20%. The problem is enhanced in rural or under-resourced clinics in under-developed or developing countries with about one-third of surgical patients getting infected, a rate which is nine times greater than in developed countries. Of the various causes, the use of contaminated medical instruments that have not been properly cleaned and sterilized directly contribute to surgical site infections with around 20 million post-operative patients infected. In absence of proper sterilization and disinfection protocols or methods these situations may become life threatening. Rural clinics in developing countries cater to 3 billion people worldwide, but do not have minimum provisions necessary to prevent post-surgical infections. Considering India has over 60% of the population living in villages, this is a serious problem and hence needs great attention.

STERI-FREEZ_Schematic IMAGE 2Thus STERI-FREEZ provides an AMAZINGLY SIMPLE on-site technology, which provides a ready to use, economic yet effective solution to the existing lacuna. This portable, cold sterilization device comprises of an insulator box housing a metallic vessel covered with a lid containing a green cryogenic biocidal mixture or Flash Freeze Elixir (FFE). Sterilization is achieved using a combination of biocides acting at subzero temperatures (-70 degree Celsius). Surgical instruments to be sterilized are kept immersed in FFE and removed just prior to use without leaving any toxic residue on the surfaces. Conventional methods of medical sterilization (autoclave, hot air, chemical and gaseous sterilization) require energy intensive instruments and long processing time while alternative sterilization techniques (Boiling in water) are not considered effective enough.

Dr. Renu Swarup Senior Advisor, DBT and MD, BIRAC honored Saugandha Das, research scholar, Department of Medical Science & Technology, Institute of Chemical Technology, Mumbai and Archit Devarajan, research scholar, Department of Medical Science & Technology, Ramnarain Ruia college, Mumbai with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

Targeted Theranostic Nanomedicines for Brain Cancer Therapy

Sonali Singh Doharey including her team member Rahul Pratap Singh, Poornima Agrawal won the award for the research project Targeted Theranostic Nanomedicines for Brain Cancer Therapy. She carried her research work under the guidance of Dr. M. S. Muthu, Prof. B. L. Pandey Banaras Hindu University, Varanasi.

Brain cancer is considered as one of the most devastating diseases because it is hard to treat and cure. Chemotherapy is the most common method for the treatment of different types of brain cancers. Unfortunately, the diagnosis and therapy of brain cancer are very unsatisfying because of the existence of the blood-brain barrier (BBB), which excludes more than 98% of small molecules and almost 100% of large molecules. Another obstacle in cancer therapy is to maintain the desired concentration of therapeutic agents and/or diagnostic agents at tumor site.

Sonali1The innovator developed targeted and controlled release nanomedicine systems including transferrin conjugated D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles and transferrin / arginine – glycine – aspartic acid (RGD) conjugated TPGS liposomes (i.e., transferrin conjugated liposomes and RGD conjugated liposomes) to deliver docetaxel (DTX) and quantum dots (QDs), simultaneously through receptor-mediated active delivery for brain cancer therapy. Innovator demonstrated that RGD or transferrin TPGS decorated theranostic liposomes were highly effective in delivering desired concentration of therapeutic agents and diagnostic agents across BBB without any signs of brain damage or edema in brain histopathology. These advanced platforms can diagnose brain cancer at early stages, initiate first-line therapy, monitor it, and if needed, rapidly start subsequent treatments. In future, brain theranostics will be able to provide personalized treatment which can make brain cancer even curable or at least treatable at the earliest stage.

Prof. Anil K Gupta, Co-ordinator, SRISTI and Founder, Honey Bee Network honored Sonali Singh Doharey, and her team, Department of Pharmacy, Banaras Hindu University, Varanasi, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

Revealed: Dual Functional Characteristics of Escherichia Coli Outer Membrane Protein Wzi And Its Implications In The Design Of Novel Antibiotics

Shivangi Sachdeva and Narendar Kolimi won the award for the research project Revealed: Dual Functional Characteristics of Escherichia Coli Outer Membrane Protein Wzi And Its Implications In The Design Of Novel Antibiotics. she carried her research work under the guidance of Dr Thenmalarchelvi Rathinavelan, Indian Institutes of Technology, Hyderabad. 

The emergence of multidrug resistance in bacteria is a major cause of infection and mortality worldwide. In Gram-negative bacteria, polysaccharide layers are one of the major virulent determinants that are involved in the evasion of host immune response as well as offers impermeability to antibiotics. Thus, inhibiting the capsular polysaccharide (CPS) biogenesis or surface exportation or its attachment to the bacterial surface may be an attractive strategy to generate avirulent Gram-negative bacterial strains. Here, the focus is on multidrug resistant Gram-negative Escherichia coli (E. coli), which is a common cause for urinary tract infections (including infections in the kidney), bloodstream infection, intra-abdominal infections such as peritonitis, skin and soft tissue infections, neonatal meningitis, diarrhea and food borne infections.

An E.coli outer membrane protein Wzi that acts as an anchor for CPS onto the bacterial surface (viz., a lectin) also exhibits a bidirectional passive water conduction property (viz., a porin). Such a dual functional role of Wzi was not realized earlier due to the occluded pore, a property that can be used to treat E. coli infections. It is observed that three water specific entry points across extracellular face regulate the water diffusion involving different mechanisms and a luminal hydrophobic plug governs water permeation across the channel. Thus, a drug molecule that can either interfere with the water conduction by Wzi or the attachment of CPS to Wzi may aid in reducing the bacterial virulence and make them susceptible to antibiotics or host immune response

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Shivangi Sachdeva, Narendar Kolimi, research scholar, , with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017  at Rashtrapati Bhavan.

A Novel Hybrid System for Textile Dye Waste Water Treatment

Bhaskar Bethi won the award for the research project A Novel Hybrid System for Textile Dye Waste Water Treatment. He carried his research work under the guidance of Dr. Shirish Hari Sonawane Department of Chemical Engineering, National Institute of Technology, Warangal.

In this project, Ultrasonic irradiation is used to initiate the emulsion polymerization to form hydro gel through the generation of free radicals as well as the uniform distribution of clay across the hydro gel polymer matrix. Recently, some attempts have been made to modify the properties of polymeric hydrogels by the incorporation of nano- or micro-particles of inorganic materials, such as montmorillonite, kaolin, mica, bentonite into the polymer networks. Hydro gels loaded with dispersed clays are a new class of composite materials which combine elasticity and permeability of the gels with high ability of the clays to adsorb different substances. The developed hybrid system for the treatment of dye waste water can be easily scaled up to industrial scale for the treatment of bulk volume of textile wastewater. It is due to its simplicity in design, less cost of material construction, low cost of operation and higher cavitation yield compared to the ultrasounic cavitation. The developed technology will be efficient for the removal of dye from aqueous medium with in short duration of operating time compared to the most of the conventional treatment techniques such as biological wastewater treatment as well as the single treatment techniques include adsorption, coagulation etc. This innovative technology mainly involves unique feature of both the degradation and subsequent absorption of dye organic pollutants from the waste water in a single set of unit.

Dr. Prof. K. Vijay Raghavan, Secretary, Department of Biotechnology, honored Bhaskar Bethi, research scholar, Department of Chemical Engineering, National Institute of Technology, Warangal, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017  at Rashtrapati Bhavan.

Atomic power plant leak – Pallava Bagla

Dear all,

Greetings from Techpedia!

Inviting students working on material science, chemistry or any other discipline to suggest possible reason.

MUMBAI, Mar 19 (PTI): In a highly guarded Indian nuclear reactor complex, toughened radiation resistant pipes have contracted ‘small pox’. As a consequence, literally in a plot similar to a Bollywood thriller Indian scientists are burning the midnight oil to unravel the mysterious nuclear leak at the Kakrapar Nuclear Power Plant in Gujarat. This 21st century atomic pot boiler is actually unfolding through the hard work of scientists, who actually share a wall with the famous property where renowned Bollywood film star Raj Kapoor used to live.

Here, they are working over-time to find out the real cause of the cryptic leaks at twin reactors in southern Gujarat. To avoid any panic and any further accidents, the Indian nuclear watchdog – the Atomic Energy Regulatory Board (AERB) – has shut down the affected plants till the cause has been found. Nuclear experts say pipes, made from a rare alloy, have contracted what seems like ‘small pox’ and this contagion has spread all over the critical tubes in two Indian Pressurised Heavy Water Reactors (PHWR) at Kakrapar in Gujarat.And, to make the matters worse, after more than a year into the investigation, the teams of scientists really do not understand what has gone wrong.

It was on the morning of March 11, 2016, and as fate would have it exactly five years after the Fukushima reactors in Japan started exploding, unit number 1 of the 220-MW PHWR at Kakrapar developed a heavy water leak and had to be shut down in an emergency.

The indigenously built nuclear plant suffered a heavy water leak in its primary coolant channel and a plant emergency was declared at the site. No worker was exposed and no radiation leaked outside the plant, confirmed India’s Department of Atomic Energy. India’s nuclear operator, Nuclear Power Corporation of India Limited (NPCIL) said “reactor had shut down safely” and “no radiation leaked out”. It confirmed that safety systems had functioned normally.

The atomic thriller really begins when experts are trying to find out why a leak recognition system failed, in the first place it should have given an alarm. “There is a leak detection system in place in all PHWRs, but in this case it failed to detect the leak on March 11, 2016,” confirms AERB Chairman S A Bhardwaj. AERB speculates that the crack developed so rapidly that the electronic leak detection system just did not had the time to react. Subsequent investigations revealed that the leak detection system was fully functioning and the operator had “NOT shut it down” to cut costs.

Nothing in the core of a nuclear reactor can be done in a jiffy and several weeks after the first leak, initial probe using a specially designed tool revealed that four big cracks had formed on a coolant tube which led to the massive leak.

The discovery of the crack was only the beginning of the mystery, further efforts to find the root cause established that the outside of the tube, the part which was not exposed to high temperature heavy water, was also for some unexplained reason “corroded”.

This was a stunning discovery, since the outside of the failed tube was exposed only to high temperature carbon dioxide and there had been no recorded case of a similar corrosion having been seen on the outside of any tube. It is also very hard to access this part since the space was very tiny in the annulus.

The AERB then ordered that all the tubes made out of a special alloy of zirconium-niobium be checked on the outside, to their surprise, they discovered that the contagion of the “nodular corrosion” or what in layman’s language can also be described as “small pox-like” was very widespread in many of the 306 tubes. Tubes made from the same batch and used at other Indian reactors continue to operate faithfully, without corrosion. The needle of suspicion now pointed to the carbon dioxide, a gas known to be very stable in high radiation environments.

A further post mortem revealed that the Unit-2 which is twin of the affected reactor had also been affected by a similar leak on July 1, 2015 almost ten months before the Unit 1 had a sudden appalling failure in March 2016. Investigations into why the Unit-2 failed were ongoing but no conclusive result had been found. This literally back-to-back failure of two fully functional nuclear reactors befuddled the engineers.

Unrelenting in trying to find out the root cause, the AERB ordered that entire assembly and not just the affected tube be safely pulled out and brought to India’s foremost nuclear laboratory, the Bhabha Atomic Research Center (BARC) in Mumbai for detailed failure analysis. It is this laboratory located at Trombay in Chembur, in Mumbai that shares geography with India’s famous Bollywood Kapoor family. In addition, since India operates another 16 similar nuclear plants, a full-fledged investigation was carried out on the coolant channels of all atomic power plants and lo-and-behold the investigating team found that the “small pox” like corrosion was confined only to the two units that operated at Kakrapar.

While this gave a sigh of relief to the NPCIL but it increased the complexity on trying to unravel the true cause of the leaks at Kakrapar. Today, Bhardwaj says the investigators are wondering if the carbon dioxide used in Kakrapar may have been contaminated which caused the “nodular corrosion” on the outside of the pipes.

The source of the carbon dioxide was further back traced and it seems only the Kakrapar plant was sourcing its gas from a “Naptha cracking unit” and possibly it has some contamination of hydrocarbons. No conclusive evidence on the contamination has been forthcoming and forensic analysis is still under way.

As it turns out nuclear engineers are masters of book-keeping especially when ageing of equipment is concerned and a more detailed check in the history of the plants revealed that in 2012 two tubes had been extracted from the Kakrapar plant as part of routine maintenance and had been safely stored in a safe warehouse. When these were re-examined in 2017, the investigators were surprised that the “small pox” like corrosion on the exterior of the tube was not present.

This now makes the investigators suspect that something went wrong after 2012. Meanwhile, the AERB and the atomic energy establishment has also reached out to the vast global nuclear community to try and help resolve this mystery.

The global watchdog the International Atomic Energy Agency in Vienna and ten other global forums have been informed that a mysterious leak is dogging the Indian reactors at Kakrapar and if the global community could be of some help. The international community is as much at a loss in explaining the failures as are the Indian teams. India operates 18 PHWR reactors and over the years it has accumulated some 348 years of operating experience of these unique nuclear plants powered using natural uranium and in all these years, the Department of Atomic Energy asserts no radiation related death has taken place at any nuclear plant and no radiation has ever leaked out of the Indian PHWR’s.

In addition to it, 29 PHWRs are today functional in Canada, Argentina, Romania, China, South Korea and Pakistan and none have reported any issue like the ‘small pox like corrosion’ on any of its nuclear plants.

Bharadwaj says right now there are only hunches but teams at BARC are exposing the Zircalloy tubes to carbon dioxide spiked with various contaminants and they are being placed in a high radiation environment to accentuate the aging process to try and determine the exact cause of the two processes—“small pox like nodular corrosion and the development of cracks in the coolant tubes.” These could be linked or independent, says Bhardwaj, who feels that in the next few months, the root cause will definitely be deciphered till then the reactors will remain shut.

India currently operates 22 nuclear reactors with an installed capacity of 6,780 MW and hopes to ramp up nuclear output to 32,000 MW by 2032. Meanwhile, the continuing nuclear mystery is giving the vast Indian nuclear establishment and its atomic sleuths ‘nuclear jitters’.

By – Pallava Bagla

Comments by Prof. Anil Gupta

a) non-uniform alloy itself, that is if alloy has been made in batches , then some batches may have had slight difference leading to patches like distortion; b) using an analogy of with disease in chickpea, where the fungus exists among roots of healthy plants also but disease manifest only in patches, probably because of changing c/n or c/p ( carbon phosph or nitrogen) ratio in those patches; the root cause may be more widely prevalent but problem may come in patches, c) is it possible that surface physics has to explain the problem.

Rotary ultrasonic Bone Drilling

Dr. Vishal Gupta received the award for the research project Rotary ultrasonic Bone Drilling. He carried his research work under the guidance of Prof. Pulak Mohan Pandey Mechanical Engineering Department, IIT Delhi.

Bone drilling is one of the steps in a typical surgical operation i.e. performed around the world for reconstruction and repair of the fractured bone. Fracture of bones is a common problem due to age factors, sports injuries, transport and industrial accidents, etc.There is always a necessity to minimize the magnitude of drilling force and torque during the bone drilling process. Thus, to minimize the rise in temperature, force and torque during surgical bone drilling process for more efficient and successful orthopaedic and trauma surgery. To attain the aforesaid, a new noble bone drilling method has been introduced recently named as RUBD. In the present research, a novel bone drilling technique i.e., rotary ultrasonic bone drilling named as RUBD has been successfully attempted to minimize the forces, torque temperature and microcracks during bone drilling. In order to perform the experimental investigations to find out change in temperature, force, torque, temperature and microcracks with RUBD using diamond coated hollow tool on bone, rotary ultrasonic tool assembly was designed and fabricated in house.

The drilling experiments were planned and carried out on porcine bones using design of experiments (Response Surface Methodology). Analysis of variance (ANOVA) was carried out to find the effect of process factors such as rotational speed, feed rate, drill diameter and ultrasonic vibrational amplitude on the force and torque. Statistical models were developed for the force and torque with 95% confidential interval and confirmation experiments have been carried out to validate the models. The results of microcracks by SEM revealed that RUBD process offered a lower force, torque, temperature and minimum microcracks, making it a potential process for bone drilling in orthopaedic surgery. It was also found that RUBD generated a much lower temperature, force and torque as compared to the CSBD.

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Dr. Vishal Gupta, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

A Virtual Reality (VR)-based Immersive Simulator for Endoscopy Training

Shanthanu Chakravarthy received the award for the research project "A Virtual Reality (VR)-based Immersive Simulator for Endoscopy Training". He carried his research work under the guidance of Prof. G. K. Ananthasuresh, Department of Biomedical Engineering, Indian Institute of Science, Bengaluru.

Virtual Reality (VR) together with haptics offers an immersive and flexible platform for training doctors in medical procedures. In this project, a VR-based endoscopy simulator together with the force-feedback system is developed. Endoscopy is minimally invasive and is used as an important diagnostic tool to detect abnormal tissues, ulcers, tumours, polyps, cancers, etc. Gastrointestinal (GI) endoscopy, including colonoscopy, is a complex procedure involving a high degree of hand-eye coordination.


These procedures are generally carried out by highly skilled clinicians. In order to practice endoscopy safely, a training system that does not involve patients is deemed important. VR-based training system developed in this work has many advantages. It is economical over a long run and usable any number of times; the training model can be changed and designed as per requirements including the incorporation of in-situ cases. It can be used for quantitatively assessing skill as recorded training sessions can be used for identifying mistakes. The developed endoscopy simulator also has many novel features. It consists of a three Degree of Freedom (DoF) haptic device, force models for real-time interaction, computer graphic models for visualization, and an ins t rumented endoscope for reali s tic interactions.Shanthanu Chakravarthy3

All the units of the simulator are uniquely integrated to provide immersive endoscopy s imulation. The device is kinematically designed to mimic real endoscopy. Furthermore, the endoscopy simulator developed in this project has the potential for extension to other interventional procedures such as colonoscopy, bronchoscopy, and endovascular training.

Dr. Francis Gurry Director General of the World Intellectual Property Organization (WIPO) honored Dr. Vikram Singh, Department of Chemistry, Indian Institute of Technology, Madras, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.​

White Light Emission from Vegetable Extracts

Dr. Vikram Singh received the award for the research project White Light Emission from Vegetable Extracts. He carried his research work under the guidance of Prof. Ashok Kumar Mishra, Department of Chemistry, Indian Institute of Technology, Madras.

White light emission (WLE) is generated from natural dyes extracted in the laboratory using a green and simple procedure. The optimized mixture of vikram singhtwo suitably chosen plant extracts using acidic ethanol, aided by a FRET cascade from polyphenolics to curcumin to anthocyanins, generates almost pure white light, with CIE values of (0.35, 0.33) in solution, (0.26, 0.33) in gelatin gel and (0.33, 0.25) in PVA film. The colour temperature of the WLE is conveniently tunable by simply adjusting the concentrations of the component emitters. The primary emitting pigments responsible for contributing to WLE are pol yphenol s and antho c y anins f rom pomegranate, and curcumin from turmeric. WLE from such cheap and nature friendly resources could be important in the context of lighting and sensing application. It would be interesting to see if such system can be used as dyes for tunable dye laser applications. Given the vast number of excellent natural fluorescent dyes obtainable from renewable biosources, approaches similar to the present could lead to a more extensive range of low-cost and efficient WLE biomaterials with ease of adjusting colour temperature, which will obviate more expensive alternatives currently being pursued.

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Dr. Vikram Singh, Department of Chemistry, Indian Institute of Technology, Madras, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

BioInvest 2017 in Bengaluru, April 04, 2017

BioInvest2017

BioInvest 2017 in Bengaluru, April 04, 2017

Greetings from ABLE!

 

I am writing this to invite you to join as at BioInvest 2017!

 

Association of Biotechnology Led Enterprises (ABLE) is organizing a one day BIOINVEST conclave on April 04, 2017 at Shangri-La Hotel, Bengaluru. The aim of the conference is to provide the networking platform for the Lifescience Start-ups,Institutional investors, Investment Bankers, Financial sponsors, and the industry to explore market opportunities and understand sectoral trends.

 

BioInvest conferences are by invitation only. Feel free to contact my colleague Pavana Praveen at pavanapr@ableindia.org.in

 

REGISTRATION CATEGORY

You can join as at BioInvest under one of the following three categories:

(i) As a Company Seeking Investment (Start-up)

(ii) As an Investor

(iii) As a  Delegate

 

REGISTRATION FEE & CRITERIA

(i) Companies Seeking Investment: Registration Fees

  • Rupees Five Thousand (Rs 5000 /- for a maximum of two people from the organization)

  • 16 companies get a  seven minute  (7 minute) opportunity to make their pitch

  • Companies will be selected by ABLE Panel after assessing the start-ups requirement and profile

(ii) Delegate Registration Fee

  • No fee

  • Only 30 seats available.

  • Entry on first-come first-serve basis.

  • Once shortlisted, invitation is not transferable.

  • No walk-in entry

 

(iii) Investor Registration Fee

  • No fee

  • Only limited seats available.

  • Entry on first-come first-serve basis.

 

REGISTRATION FORM & DEADLINES

Find below the links to complete the registrations under the relevant category.Click to Register.

(i) Companies Seeking Investment: Registration Fees

(Deadline – March 17, 2017 to submit your application. March 21, 2017–Intimation by ABLE on shortlisted names and confirmation / Fee Payment)

(ii) Delegate Registration Fee

(Deadline – March 20, 2017)

 

(iii) Investor Registration Fee

(Deadline – March 21, 2017)

VENUE & SCHEDULE

Shangri-La Hotel, Bengaluru,
No 56-6B Palace Road, Bengaluru, 560052
Event Timings: 1030 – 1640 Hrs on Tuesday, April 04, 2017

IIT Kanpur: Students felicitated for developing Braille slate ~ indiatoday.in

Students of the Indian Institute of Technology-Kanpur (IIT-K) were given the Gandhian Young Technological Innovation Award-2017 for developing a prototype of a Braille slate called 'Anubhav' at a function held at Rashtrapati Bhawan on March 5.

Gandhian Young Technological Innovation (GYTI) Awards celebrates the spirit of student innovation in all the fields of engineering, science, technology and design through extremely affordable/frugal solution or the ones pushing the technological edge.

As per an HT report, there were 2,715 nominations from 308 institutions and universities from 27 states and two Union Territories across 54 different subject disciplines. This year, 22 innovations were selected for the award and another 17 for appreciation. 

First device to help visually impaired read and write simultaneously:

The idea was to develop 'Anubhav' was initiated by Sachin NP and Vimal Chandru, design programme students who worked under the guidance of Prof Shantanu Bhattacharya. According to them there was no single device that could help the visually impaired read and write simultaneously before this.

Sachin, who graduated from IIT-K and is currently working with a German company, said: "The award is a reward for our hard work. It will inspire us to do more innovation and bring about a change in society. Technology should be used for the betterment and welfare of society."

 "So we thought of sorting out the issue. The idea was to make a single device that can perform the functions of both the Braille slate and the Taylor's board," said Sachin and Vimal.

87165 The Braille slate has two polymer-based pads hinged to one side, a single row of metal stencil with Braille cell patterns etched on it and an ergonomic stylus with a hollow cylindrical tube.

'Anubhav' consists of cells with raised dots arranged on a slate and a stencil that slides down vertically from one row to the other. Using the hollow-tube stylus, the raised dots can be embossed on a paper placed between the pads. 8041IMG_20160503_164708

"The device has been tested with visually impaired children in Kanpur (Andh Vidyalaya students), and the results have been very encouraging," claimed Sachin, adding, "This project has been in progress for the past one year. 'Anubhav' was the result of thorough research. Now, we are trying to approach the state government to make this product available in the market."

Source : http://indiatoday.intoday.in/education/story/iit-kanpur/1/899503.html