Avisek Barla and his team members Abrar Ali Khan, Sameer Sharma, Vijay Anand, Nitish Kumar Singh won the award for the research project Affordable Paper Microfluidic Device for Blood Glucose and Cholesterol Detection. He carried his research work under the guidance of Dr. Vignesh Muthuvijayan, Indian Institute of Technology, Madras.
Non-communicable diseases (NCDs) can easily be held responsible for majority of the deaths worldwide and India is no exception. The work is done on detecting diabetes, cholesterol and predict its cumulative effect. There are specific cases of brain stroke leading to complete or partial paralysis including severe cognitive impairment in the long term. The huge demand for diagnosis has flooded market with Point of Care devices for diabetes, but not yet for cholesterol. The cost of an average device is Rs 800-1500 in the market, but in this project, the price point of the strips used is around Rs 15-50. Thus, a lowcost paper based sensor meant for the masses is made. One would require to add a few drops of blood to the device and colour change will happen in the specified region. A camera is used to quantify and measure colour to display the concentration. The data collected will be used to map the prevalence of the disease and predict the occurrence of strokes. The work is in the process of making a blood drawing mechanism and plasma separation unit which will complete the picture of a true consumer device at nominal price.
Dr. Prof. K. Vijay Raghavan, Secretary, Department of Biotechnology, honored Avisek Barla, research scholar, Indian Institute of Technology, Madras, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 Appreciation at Rashtrapati Bhavan.
Prof. Ashok Kumar Mishra, Department of Chemistry, explains, “Plants are rich sources of many classes of molecules that absorb light and emit in the visible wavelength ranges. Our reported work shows that judicious choice of such molecules can provide cheap and environment-friendly sources of white light emission systems. This is essentially a ‘proof of concept’ work and further research is necessary to address the issues of molecular/material stability and device compatibility”.
Dr Vikram Singh says, “Receiving the prestigious GYTI Award at Rastrapati Bhawan was a big honour for me and I am delighted. I will be using the Rs 15 lakh award grant to continue my research on white light emitting material from plant sources. I plan to research on RGB Emitting Carbon Quantum Dots from Vegetables/Fruits extract”.
The BIRAC-SRISTI award for biotechnological/medical/healthcare innovation is given to a technology having the potential to reach the masses and/or address a felt social need or making it extremely affordable compared to the available solution. Up to fifteen of the selected innovations may be given a grant of Rs.15 lakh each and another hundred ideas may be granted Rs 1 lakh each for taking the idea forward.
Several students also won GYTI appreciation awards.
• Anupam Chandra and Ramesh Kumar (Project Associate) for their project entitled Portable Geo-specific Water Filtration Bottle. They were guided by Prof. T Pradeep.
• Arvind Pujari, Tanay Garg, Shashwat Jain, Kushal Kumar Reddy DVSS and Subham K Sahana for their project entitled A Mechanism for Toilet Seat Sanitation. They were guided by Prof. Anil Prabhakar.
• Avisek Barla, Abrar Ali Khan, Sameer Sharma, Vijay Anand and Nitish Kumar Singh for their project entitledAffordable Paper Microfluidic Device for Blood Glucose and Cholesterol Detection. They were guided by Dr Vignesh Muthuvijayan.
• Mallikarjunachari G for his project entitled Design of a Mechanical Device (Nanorobot) for Diagnosis and Removal of Plaque from Human Heart Artery System. He was guided by Dr Pijush Ghosh.
• Mannam Naga Praveen Babu for his project entitled Fish-Inspired Propulsion for Remotely Operated Surfaces Ships and Underwater Vehicles. He was guided by Prof. P Krishnankutty.
The GYTI Awards celebrate the spirit of student innovation in all the fields of engineering, science, technology and design through extremely affordable/frugal solution or the ones pushing the technological edge. These could deal for example, with a) communities at grassroots, b) co-creation with grassroots innovators, c) ‘manufacturable’ technologies for saving or generating energy, sanitation, water purification, saving material consumption, d) biotechnology and medical devices, e) diagnostics, f) assistive devices for physically challenged, and all others areas of social and industrial applications.
One can submit more than one application in hardcore manufacturing areas, including but not restricted to aerospace, transportation, construction, textile, electronics, nanotechnologies, computer science applications etc.
The SRISTI (Society for Research and Initiatives for Sustainable Technologies and Institutions) instituted the awards to encourage innovative student projects in engineering, pharmacy, science and other applied technologies. They are given every year during the Festival of Innovation (FOIN) at Rashtrapati Bhawan in March.
For any query, contact Team Techpedia-GYTI at email@example.com, contact no: +919099258492. For looking at the awards given this year, please visit www.techpedia.in, www.sristi.org initiative.
Animesh Laha, Student of the Indian Institute of Technology, Delhi received the Gandhian Young Technological Innovation Award-2017 for developing a prototype of Indigenous Technology of Soft Body Armour for Defence Applications Using 3D Woven Aramid Fabrics. He carried his project under guidance of Dr. Abhijit Majumdar.
Soft body armours are developed by using multiple layers of high performance fabrics. Generally, 30-40 layers of 2D fabrics woven aramid fabrics (Kevlar, Technora etc.) or ultrahigh molecular weight polyethylene (UHMWPE) sheets are assembled together to make soft armour panel which becomes heavy and inflexible. In this innovation, two approaches have been amalgamated to reduce the weight of body armour. 3D fabrics, in which yarns are arranged in three perpendicular directions, namely X, Y and Z were produced in the laboratory. 3D fabrics were then treated with shear thickening fluid (STF).
STF treated 3D fabric prototypes developed in this research have been tested against 9 × 19 mm bullets (430 m/s). Soft armour panel having STF treated 3D fabrics stopped bullets fired at 430 m/s. The areal density of the panels was 4500 g/m square. Moreover, the depth of back face signature for these fabrics was varying from 31 to 39 mm which is within the acceptable limit (44 mm). The panel containing STF treated 3D fabric showed dome formation, crack generation and fibre breakage to a lesser extent as compared to those of fabric panels containing untreated 3D fabrics.
Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Animesh Laha, Department of Textile, Indian Institute of Technology, Delhi, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhavan on March 5.
The COEP Satellite Initiative team from College of Engineering, Pune received the award for the project 'Swayam- Passively Stabilized Communication Satellite'. They carried their project work under the guidance of Dr. M. Y. Khaladkar and Dr. B. B. Ahuja.
Swayam is a pico-satellite developed by undergraduate students of College of Engineering, Pune. Swayam is a passively stabilized communication satellite of dimensions 10 X 10 X 11.35 cm and mass 990 g. Swayam was launched by ISRO on 22nd June, 2016 by PSLVC34. Swayam is currently in-orbit and data is being downlinked at COEP ground station and analysed on a regular basis. Student satellites offer a distinct challenge in terms of reliability and interdisciplinary nature of design. To achieve the highest standards of design and fabrication, the project was organized into five constituent subsystems. Attitude control is achieved by a passive magnetic attitude control system to satisfy the space and energy constraints. This system consists of an orthogonal arrangement of magnet and hysteresis rods. Volume, strength and placement of magnetic materials are the major design considerations. A numerical simulation has been developed to conclude the effect of various design parameters on stabilization time and its feasibility for the communication payload. Swayam has a half-duplex communication subsystem. Beam of the antenna is optimized to offer maximum communication link time in conjunction with the available pointing accuracy. To satisfy the power budget of the satellite, the autonomously sent beacon is sent at lesser power than the digital payload data. The power subsystem of the satellite is fully analog capable of functioning independently. Swayam as a template is ideal for carrying low profile payloads which do not require magnetically clean environment. Swayam is also an experiment which shows the cohesive application of passive stabilization for a communication satellite in low power environment.
For this innovation Dr.Anil Sahasrabudhe, Chairman of the All India Council for Technical Education, honored team COEP Satellite Initiative, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.
Dr. Parikshit Moitra and Dr. Deepa Bhagat from Indian Institute of Science, Bengaluru were given the Gandhian Young Technological Innovation Award-2017 for developing a prototype of A Novel Bio-engineering Approach to Generate an Eminent Surface Functionalized Template for the Selective Detection of Female Sex Pheromone of Certain Agriculturally Hazardous under guidancep of Prof. Santanu Bhattacharya.
Plant pests exert serious effects on food production due to which the global crop yields are reduced by ~20-40% per year, as estimated by FAO. Hence to meet the world's food needs, loses of food due to crop pestsmust be reduced. Herein silicon dioxide or zinc oxide based MEMS devices are covalently functionalized for robust and efficient optical sensing of the female sex pheromones of the pests like Helicoverpa armigera, Scirpophaga incertulas and Bactocera oleae for the first time in literature.
The relative sensitivity of the functionalized MEMS devices is improved by the variation in functionalization protocols that either increased the number of amine or β-cyclodextrin functionalities on each anchor site. The functionalized devices are also capable of selectively measur ing the concentration of this pheromone at the femtogram level which is much below the concentration of pheromone found at the time of pest infestation in an agricultural field. Again, the reversible use of the functionalized devices in any season under ambient conditions, photochemical and thermal stability of the devi c e s and absolut e ly t roubl e f r e e transportation of these pheromone nanosensors heightens their potentials for commercial use. Overall, a novel and unique approach is reported herein for the selective and reversible sensing of female sex pheromones of certain hazardous pests which may be efficiently and economically carried forward from the research laboratory to the agricultural field to determine the stage of prior pest infestation. Necessary actions can then be taken as and when necessary in a confined region of alerted pest attack.
Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Dr. Parikshit Moitra, Department of Agricultural Engineering, Indian Institute of Science, Bengaluru, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhawan on March 5.
Madhav Aggarwal, Mohd. Suhail and Bhavesh Pachnanda, Students of the Delhi Technological University, Delhi were given the Gandhian Young Technological Innovation Award-2017 for developing a prototype of a Navyo – The Smart Glove under guidance of Dr. Vikas Rastogi.
In the midst of the fast paced life and era of technology, a blind person is still in state of confusion that how will he/she manage to reach his/her destination. Due to his/her impairment, he/she is unable to find his direction (i.e. from where to take a left or a right turn) and eventually gets lost every now and then. So, another person becomes necessary for guiding him along the path. This makes him/her highly dependent on others for his mobility.
With this, not only does he reduce his productivity but also, loses his freedom and confidence to walk alone. So, to cater the aforementioned problem a smart glove that will guide the person turn by turn to reach the destination via vibrations is created. Navyo is accompanied by a mobile App, interface of which is simple and easy to use. User simply needs to speak out the destination in App. Navyo then connects to app via Bluetooth and the person is ready to go. As per the map, when the left turn approaches, the frequency of vibration also starts increasing in left portion of hand indicating left turn and stops when turn is taken. This way by following different vibration patterns at different maneuver points (i.e. right turn, overhead bridges, underpass etc) destination can be reached out easily. In case, user has missed out any vibration instruction on glove, then it can be repeated by simply pressing a button on Navyo. The solution is based on haptic feedback technology which is safe and non-distractive from blind person's point of view. Also, this solution provides the hassle-free way for navigation by allowing user to speak the destination and walk with mobile phone inside pocket/purse etc.
Dr. Francis Gurry Director General of the World Intellectual Property Organization (WIPO) honored Madhav Aggarwal, Department of Electronics, Communications & related fields, Delhi Technological University, Delhi, with the prestigious Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhawan on March 5.
Manashi Chakraborty, Dr. Santanu Patsa and Dr. Nishat Anjum received the award for the research project Non-invasive, Point-of-care Diagnostic System for Early Detection of Oral Cancer using Digital Infrared Thermal Imaging. She carried her research work under the guidance of Dr. Sudipa Mukhopadhyay, Indian Institute of Technology, Kharagpur.
This project is the pioneering attempt to develop a non-invasive, non-ionizing, radiation hazard free, point-of-care computer aided diagnostic framework for oral cancer detection using machine intelligence and Digital Infrared Thermal Imaging (DITI). Oral cancer is the most common cancer in India where approximately 14 people die/hour. Patients are unable to avail diagnosis due to scarcity of state-of-the-art infrastructure and oral-pathologist. Patients are reluctant to go for invasive biopsy. All these along with absence of screening facility pose hindrance to early diagnosis. Due to abnormal metabolic activities in carcinogenic facial regions, heat signatures of patients are different from that of normal subjects. Asymmetry of temperature distribution was compared between facial regions (opposite sides of frontal image and between left and right profile images) for patients and normal subjects.
The analysis suggested that patients manifest greater asymmetry compared to normal subjects. This project requires only a one-time investment of a long infrared thermal camera, image processing and machine learning software and a laptop/workstation. Thus, there is minimal resource requirement. Also, Digital Infrared Thermal Imaging (DITI) has no recurring or maintenance cost. The image acquisition protocol is so simple that even a high school student can acquire the images. It provides on-spot oralcancer screening facility and is portable. Thus, screening camps can be organised even in remote villages with minimal infrastructure. As DITI has no recurring cost, it can be scaled up to cater the huge population of developing countries like India.
Dr. Prof. K. Vijay Raghavan Secretary, Department of Biotechnology, honored Manashi Chakraborty, Department of Medical Science & Technology, Indian Institute of Technology, Madras, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhavan on March 5.
Appidi Tejaswini, Syed Basseruddin Alvi , Anurag Meena Students of the Indian Institute of Technology, Hyderabad were given the BIRAC-SRISTI Gandhian Young Technological Innovation Award-2017 for developing a prototype of an Affordable detection kit for Cervical Cancer under guidance Dr. Aravind Kumar Rengan.
Cervical cancer is treatable, if diagnosed early. The screening/diagnostic procedures available are time-consuming and explorative. A system which is simple, economical with immediate results is needed to increase frequency of screening. The innovation has paved way for the development of one such system.
A technique is developed to quantify the acetic acid that is used for protein coagulation which is responsible for the aceto-white patches in VIA [Visual Inspection with Acetic acid, a conventional screening procedure for detection of Cervical cancer/Cervical intraepithelial neoplasia (CIN)]. The percentage of acetic acid is quantified; such that various percentages would result in various colors. This will help to identify the presence of cervical cancer/CIN without naked eye observation as required in VIA. This technique will be embedded into a paper/strip based device which can be initially used as an assistive technique but has the capability to emerge as self-screening tool. A qualitative screening procedure VIA is also quantified which can be easily embedded into paper/strip based device for the development of an economical, easy to handle kit which will increase the frequency and improve the ease of screening which would in turn increase the Cervical cancer survival rate.
For this innovation Dr. Renu Swarup Senior Advisor, DBT and MD, BIRAC, honored Appidi Tejaswini, Department of Nano Science and Engineering, Indian Institute of Technology, Hyderabad, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan on March 5.
Sutapa Chandra, Rosna Binish, Arvind Dhawangale students of the Indian Institute of Technology, Bombay were given the BIRAC-SRISTI Gandhian Young Technological Innovation Award-2017 for developing a prototype of a Portable Biosensing Platform Based on Conducting Polymer Decorated Optical Fiber for Bacteria as well as Heavy Metal Sensing in Tap Water under guidance of Prof. Soumyo Mukherji.
The presence of water borne bacteria and heavy metals in tap water could be a potential human health risk and may lead to death of young children and adult. To address this issue, a common platform is developed for detection of water contaminants (bacteria and heavy metals) in tap water. The primary sensing mechanism is based on change of optical properties of polyaniline (conducting polymer) due to the binding of water contaminants on the polyaniline coated fiberoptic sensor probe. The experimental setup consists of a broadband light source, light focusing optics and fiber-optic spectrometer. Depending on the analyte (heavy metals, bacteria etc.), polyaniline coated optical fibers were functionalized with different receptors. Thus, by changing the surface chemistry of the polyaniline coated sensor probe, it can be made specific towards detection of different analyte. As a proof of concept, it is demonstrated that as low as 20- 60 cfu/ml concentrations of E. coli and 1 picomolar concentration of lead ions are detectable using this system.
The deliverable will be a marketable prototype of an optical fiber sensor integrated with microcontroller unit. The novelty lies in the alteration of optical properties of polyaniline and its utilisation for water contaminants sensing. The detection limit aimed by this technology will surpass the conventional methods available for detecting these analytes. The sensitivity and specificity available by this technology ensures its applicability in water industry.
For this innovation Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Sutapa Chandra, Department of Bioengineering, Indian Institute of Technology, Bombay, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan on March 5.
Students of the Indian Institute of Technology, Kharagpur were received the BIRAC-SRISTI Gandhian Young Technological Innovation Award-2017 for developing an Affordable and Rapid Paper-based Test Kits for Antimicrobial Susceptibility Assays.
Shantimoy Kar including team members Tarun Agarwal, Shubhanath Behera, Varun Varma developed this test kit under guidence of Dr. Suman Chakraborty and Prof. Tapas K. Maiti. At the present scenario, increasing drug resistance of the pathogenic microbes is a global threat to the human mortality. To meet this challenge, there is a need to develop a rapid antimicrobial susceptibility testing platform. The cur rent methodologies for detec ting antimicrobial susceptibility suffer from severe limitations, thereby negatively effecting patient's survival rates. These techniques are time consuming, labor intensive, require sophisticated infrastructures and skilled personnel; which collectively increase overall cost of the diagnosis. In this context, herein, a simple paper based microfluidics platform for easy and rapid execution of antimicrobial susceptibility assays is developed.
The device consists of a paper-based platform which includes four different layers: a base layer, a bacterial suspension layer, a drug layer and a top layer containing a chromogenic substrate which changes color in accordance to the bacterial metabolic activities. The developed technology provides faster detection (~ 5-6 h) and multiplexing (upto 8 different samples could be analyzed) in comparison to the gold-standard stereotype laboratory practices. Moreover, portable nature and ease of fabrication method collectively make it more convenient for functioning at resource limited settings.
For this innovation Prof. Anil K Gupta Co-ordinator, SRISTI and Founder, Honey Bee Network, honored Shantimoy Kar and team Tarun Agarwal, Shubhanath Behera, Varun Varma, Department of Applied Technology, Indian Institute of Technology, Kharagpur, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.
The Carbon Zero Challenge is a pioneering initiative by IIT Madras and IWMA in collaboration with the US Consulate General, Chennai. CZEROC seeks innovative ideas and proof-of-concept solutions from students and entrepreneurs in Tamil Nadu, Kerala, Karnataka, Puducherry, and the Andaman and Nicobar Islands.
Nitin Vasanth, student of the Cochin University of Science & Technology, Cochin received the BIRAC – SRISTI Gandhian Young Technological Innovation Award-2017 for developing a prototype of a NeuroBuds: Brain Wave Mapping Smart Earphones for Rural India under the guidance of Prof. Unni A M.
An average human brain consists of over 80 billion neurons. These communicate with each other by sending short ionic impulses, which in turn creates small voltage fluctuations around the proximity of brain. By placing highly sensitive sensors, these fluctuations can be used to understand the brain activity. NeuroBuds is a pair of smart earphones that have these specially fabricated sensors embedded into it to understand the brain activity of user. These sensors are integrated into the architecture of an earphone along with a pre-processor. The data from the sensor is passed on to the Smartphone from where the rest of processing is done. This way of utilization of smartphone processor and smartphone battery to power NeuroBuds reduces the requirement for dedicated on-board processor and battery module reducing the size of device greatly. More importantly this helps reduce the device cost to a price point that makes it accessible to common man who is usually unable to explore other expensive brain activity solutions that exist now. The brain data is analysed to look for anomalies in pattern that indicate brain disorders like Epileptic seizures. This kind of early detection helps in doing pre-emptive action and sending out alerts/SOS. The brain wave data is also used to analyse the mental state of the user, their concentration levels and stress levels. At a time when the working population suffers from stress related issues and sleeping disorders due to a fastpaced lifestyle, NeuroBuds can be used as a mental health monitor. Once the application has enough data coming in from different users, it can recognize patterns and optimize algorithms on its own using the underlying neural network. NeuroBuds serves as the perfect link between the user and the smartphone to monitor other body vitals including heartbeat.
Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Nitin Vasanth, Department of Biomedical Engineering, Cochin University of Science & Technology, Cochin, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.
Dilshad Ahmad Khan and his team member Faiz Iqbal, Zafar Alam won the Appreciation award for the project Design & Development of Automated Five Axis CNC Ball End Magnetorheological Finishing Machine. He carried his project work under the guidance of Dr. Sunil Jha, Indian Institute of Technology, Delhi.
The project is an innovation and technology based work aimed at providing nano level finish on various materials of complex shapes and size. This project is related to the design and development of a fully automated five axis CNC ball end magnetorheological finishing (BEMRF) setup from the conceptual idea to an industry standard machine. The developed machine caters to the demand of today's advanced industries which deals in finishing of 3-D dies, high precision lenses, orthopaedic implants, jewelleries and gems etc. In the first phase of the project an idea is conceptualized to finish 3-D complex surfaces using magnetorheological polishing (MRP) fluid. After checking the feasibility of the concept, a BEMRF tool is developed which is later mounted on a CNC machine setup. The newly developed finishing process is used to finish ferromagnetic as well as nonmagnetic materials of complex shapes and sizes using specially prepared magnetorheological polishing fluid. Apart from nano finishing on the surfaces, the measurement of surface roughness of the workpiece is also needed to be wear free which is not the case in stylus based measurement systems. Therefore, a non-contact roughness measurement instrument (confocal sensor) is incorporated in BEMRF machine. The confocal sensor is light, compact and easily mounted on the BEMRF tool for quick and error free measurement of surface roughness after the BEMRF process. In BEMRF machine the forces can be controlled automatically thereby enabling the user to select suitable force according to the material to be finished.
Anil Sahasrabudhe, Chairman of the All India Council for Technical Education, honored Dilshad Ahmad Khan, research scholar, Indian Institute of Technology, Delhi, with the prestigious Gandhian Young Technological Innovation (GYTI) Appreciation award 2017 at Rashtrapati Bhavan.
Students of the Indian Institute of Science, Bangalore Dhiraj Indana including his team member S.C.G. Kiruba Daniel, Varun S, Prateek Katare who worked under the guidance of Dr. Sai Siva Gorthi received the Gandhian Young Technological Innovation Award-2017 for developing a prototype of a Low Cost Automated Handheld Melamine Detection Device (for Testing Melamine in Milk).
Even though a number of kits and devices are available for detecting common milk adulterants like urea, boric acid, water, sugar and detergents, there is hardly any portable device available for the detection of melamine. Till now, bulky instruments like Gas Chromatography (GC), HPLC, GC-MS and LC-MS are being used for detecting melamine which costs between 25 to 50 lakhs rupees, as well as requiring skilled personnel for operation. A fully automated handheld device to detect melamine from milk with integrated milk pre-processing step done using chemical dried cotton is developed. Melamine is finally detected through interference in Silver nanoparticle formation. Both the preprocessing and detection steps are innovative and patented. The cost of the device may be few thousand rupees which is almost 1000 times lesser than the price of existing conventional instruments. The developed device is user-friendly Low Cost Automated Handheld Melamine Detection Device (for Testing Melamine in Milk) which can give the level of melamine adulteration in ppm directly. Thus, the device not only tells the user whether the milk is fit for consumption or not but also gives the exact concentration of melamine in milk. This device fulfills the goal of taking melamine sensing to every household so as to protect every person from melamine adulteration.
For this innovation Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Dhiraj Indana, Department of Nano Science and Engineering, Indian Institute of Science, Bangalore, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhawan on March 5.
K. Rajasekhar and Kavita Shah received the award for the research project Near Infrared Fluorescence Probes for Diagnosis of Alzheimer's disease. He carried his research work under the guidance of Prof. T. Govindaraju, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru at a function held at Rashtrapati Bhawan on March 5.
Selective detection and staining of toxic amyloid beta (Aβ) plaques found in the Alzheimer's disease (AD) brain is crucial for clinical diagnosis and monitoring of the disease progress. Herein, a coumarin-quinoline (CQ) conjugate-based molecular rotor type, turn-on near-infrared (NIR) fluorescence probe for selective and specific detection of Aβ fibrillar aggregates is designed. The probe CQ selectively binds to Aβ fibrillar aggregates over other toxic protein aggregates such as Tau, α-synuclein (α-Syn) and islet amyloid polypeptide (IAPP), and exhibit ~100 fold fluorescence enhancement with nanomolar binding affinity (82 nM). CQ effectively displace Thioflavin T bound to Aβ fibrillar aggregates and exhibit multiple binding sites on Aβ fibrillar aggregates which is extensively studied through fluorescence resonance energy transfer (FRET) and molecular docking. Remarkably, CQ unambiguously stains Aβ plaques in human brain tissue over its co-existing Tau aggregates, neurofibrillary tangles (NFTs), which are strongly associated in AD and in various tauopathies. This is a highly desirable attribute to distinguish AD from disease conditions caused by Tau pathology.
Dr. Francis Gurry Director General of the World Intellectual Property Organization (WIPO) honored K. Rajasekhar, Department Biological Sciences, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.
Subham Banerjee won the award for the research project Prophylactic Transdermal Patch Against Neurotoxin Poisoning In Biological Warfare Situations. He carried her research work under the guidance of Dr. Pronobesh Chattopadhyay, Dr. Animesh Ghosh Defence Research Laboratory, Tezpur Birla Institute of Technology, Mesra.
Drug-in-adhesive matrix type combinational prophylactic transdermal patch composed of eserine and pralidoxime chloride (PAM) against acetyl choline agonist (±)-anatoxin a neurotoxin poisoning was developed. Initially, a simple RPHPLC method was developed and validated for the s imult aneous de t e rmina tion and quantification of eserine and 2-PAM using UV detection. The method was validated as per ICH guidelines for validation of analytical procedures, and was applied for the routine analysis of these two drugs in fabricated transdermal patches.
Adhesive matrix type transdermal patches containing eserine and 2-PAM were prepared by solvent casting method. The drug combinations were incorporated in adhesive matrix type system supported by a polyester film laminate backing membrane and attached to a temporary releaseliner. The dermal patches were having desired properties such as thin, circular, opaque, smooth, homogeneous, sticky, uniform, flat and flexible in nature. The drug release was sustained from all the formulations up to 72 h and following anomalous (non-fickian) diffusion and fickian release mechanism for eserine and 2-PAM, respectively. Optimized transdermal patch exhibited highest acceptable levels of tackiness with good adherence capacity and showed promising stability potential with respect to all points of analysis. From safety point of view, the optimized transdermal patch was safe for application to the skin with no dermal and mutagenic toxicity as well. Pharmacodynamic study proved that the optimized transdermal patch was effective against acetyl choline agonist (±)-anatoxin a neurotoxin poisoning. While pharmacokinetic study revealed that the systemic absorption of the drugs from the fabricated best optimized patch through the skin was sufficient enough to achieve pharmacodynamic efficacy.
Dr. Prof. K. Vijay Raghavan Secretary, Department of Biotechnology honored Subham Banerjee, Defence Research Laboratory, Tezpur Birla Institute of Technology, Mesra, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.
Saugandha Das including her team member Archit Devarajan won the award for the research project STERI-FREEZ: Flash Freeze Sterilization. She carried her research work under the guidance of Prof. Padma V. Devarajan Institute of Chemical Technology, Mumbai.
Surgical site infections are one of the most common complications associated with surgery, with reported incidence rates of 2-20%. The problem is enhanced in rural or under-resourced clinics in under-developed or developing countries with about one-third of surgical patients getting infected, a rate which is nine times greater than in developed countries. Of the various causes, the use of contaminated medical instruments that have not been properly cleaned and sterilized directly contribute to surgical site infections with around 20 million post-operative patients infected. In absence of proper sterilization and disinfection protocols or methods these situations may become life threatening. Rural clinics in developing countries cater to 3 billion people worldwide, but do not have minimum provisions necessary to prevent post-surgical infections. Considering India has over 60% of the population living in villages, this is a serious problem and hence needs great attention.
Thus STERI-FREEZ provides an AMAZINGLY SIMPLE on-site technology, which provides a ready to use, economic yet effective solution to the existing lacuna. This portable, cold sterilization device comprises of an insulator box housing a metallic vessel covered with a lid containing a green cryogenic biocidal mixture or Flash Freeze Elixir (FFE). Sterilization is achieved using a combination of biocides acting at subzero temperatures (-70 degree Celsius). Surgical instruments to be sterilized are kept immersed in FFE and removed just prior to use without leaving any toxic residue on the surfaces. Conventional methods of medical sterilization (autoclave, hot air, chemical and gaseous sterilization) require energy intensive instruments and long processing time while alternative sterilization techniques (Boiling in water) are not considered effective enough.
Dr. Renu Swarup Senior Advisor, DBT and MD, BIRAChonored Saugandha Das, research scholar, Department of Medical Science & Technology, Institute of Chemical Technology, Mumbai and Archit Devarajan, research scholar, Department of Medical Science & Technology, Ramnarain Ruia college, Mumbai with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.