Development of low grain arsenic rice by the fungal arsenic methyltransferase via bio-volatilization

Students of CSIR – National Botanical Research Institute, Lucknow, Shikha Verma and Dr Pankaj Kumar Verma won the award for a Development of low grain arsenic rice by the fungal arsenic methyltransferase via bio-volatilization. They carried their project work under the guidance of Dr Debasis Chakrabarty.

Numerous studies have been extensively documented for the benefits of Continuous Subcutaneous Insulin Infusion (CSII) over Multiple Daily Injections (MDI) for insulin therapy in Type 1 Diabetes Mellitus (T1DM) patients. Despite such overwhelming evidence in support, the adoption of CSII is sparse, particularly in resource-constrained settings like India. Apart from the institutional factors, fixed and recurring costs of such a device are often found to be a withholding factor for widespread application. The abstract describes the development of a novel, affordable insulin pump for T1DM patients matching the specifications of a state-of-the-art pump, while significantly bringing down the fabrication cost. Most pumps rely on a lead screw/nut coupled with a geared DC motor to achieve precise micro-motion. These motors typically make use of micro-gears as a means of speed reduction, which is inherently expensive to manufacture. Consequently, they contribute significantly to the final cost of a pump. In this work, we take an innovative approach to distribute the requisite speed reduction in multiple stages, with an acceptable compromise on the product size. The system is actuated by a nominal DC geared motor and a novel mechanism of converting continuous rotary input to intermittent output. The kinematic chain is feedback-controlled which ensures volumetric accuracy of the delivered fluid. The pump can be wirelessly controlled via a remote. The same wireless channel can be used to connect to a Continuous Glucose Monitoring (CGM) device for subsequent integration with an Artificial Pancreas system. Preliminary accuracy tests showed promising results when compared with commercially available devices.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Shikha Verma and Dr Pankaj Kumar Verma, CSIR – National Botanical Research Institute, Lucknow at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Developing Labscale Magneto-Mechanical Experimental Setup to Predict the Plaque Growth of Human Heart Coronary Arterial Layer System

Student of Madanapalle Institute of Technology and Science (MITS) Andhra Pradesh, Mallikarjunareddy Reddy Boreddy won the award for a Developing Labscale Magneto-Mechanical Experimental Setup to Predict the Plaque Growth of Human Heart Coronary Arterial Layer System. They carried their project work under the guidance of Dr Mallikarjunachari G.

In India, one out of six men and one in ten women die from heart disease and the death rate is significantly increasing day by day. According to present estimates, India will soon have the highest number of heart disease cases in the world. Conferring to the Indian Heart Association, 50% of all heart attacks in Indians occur under 50 years of age, and 25% of all heart attacks in Indians occur under 40 years of age. One of the primary reason for coronary heart disease is the growth of plaque in the heart arterial wall layers. The ratio of a number of heart patients to the available specialized cardiovascular doctors is significantly high. Moreover, the average cost of a less severe heart attack is about £ 600,000. All the above statistics indicate that the necessity of escalating the research in human heart artery system. In this regard, developing cost-effective experimental setup is an alternative way to fulfil the need. The identification and removal of plaque at the initial stages further bring down the cost significantly. Developing a labscale magneto-mechanical device to predict the plaque growth of human heart coronary arterial layer system. Plaque is the fatty (waste) substance that forms in between the heart arterial wall layers. The growth of this plaque at the interface of the layers blocks the blood flow and finally leads to a heart attack or stroke. Identification of the plaque growth at the interface is one of the major challenges for the biomedical research community. Our team is very confident that this study will be extremely useful to researchers from the area of biomedical science, material science, interface biology and also from nanoengineering.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Mallikarjunareddy Reddy Boreddy, Madanapalle Institute of Technology and Science (MITS) Andhra Pradesh at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Artificial Bio-markers of Knee Osteoarthritis

Student of Indian Institute of Technology, Delhi, Nikhil Gupta and Dr Alok Prasad won the award for an Artificial Biomarkers of Knee Osteoarthritis. They carried their project work under the guidance of Prof. Tapan Kumar Ghandhi
Knee osteoarthritis is a chronic, progressive disease characterized by the loss of cartilage in joints. It is one of the biggest problem affecting a large number of elderly people today. Commonly, orthopaedics use radiographic techniques like X-ray, CT-Scan, MRI etc. to look for the deterioration in cartilage or damage in the bones. But, it has been found out that almost 50% of patients with symptomatic Knee, OA shows no signs in radiographs because of the low sensitivity of these diagnostic tools. The lack of biomarkers of knee OA and 35+ different ways a patient describing the pain leads to a lot of subjectivity in the diagnosis, lack of specific treatment for patients, and poor quantification of post-treatment stage. We have created an IOT enabled device which in congestion with a sophisticated machine learning algorithm that detects Knee OA at an early stage from the walking pattern of a subject. The device collects 1000+ data points about the walking pattern and learns to create features which categorize the patient as per their medical condition. This high touch solution can greatly help caregivers & doctors to understand the complication in a comprehensive manner. Doctors can now suggest much better treatment with specific supplements, drugs, and surgical recommendations. This device in combination with an app will be highly useful specifically to early-stage subjects to help them track their disease condition and actually see themselves improving due to the results of management measures they are taking.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Nikhil Gupta and Dr Alok Prasad, Indian Institute of Technology, Delhi at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Novel and Eco-friendly lightweight Thermal Insulating Ceramics from Thermal Power Plant Waste

Student of Institute of Chemical Technology, Mumbai, Yogesh D. Urunkar and Chandrakant S. Bhogle won the award for a Novel and Eco-friendly lightweight Thermal Insulating Ceramics from Thermal Power Plant Waste. They carried their project work under the guidance of Prof. Aniruddha B. Pandit and Prof. J.B. Joshi.

India alone produces 169 MT of the fly ash per annum from 155 thermal power stations, out of which 50% were unutilized and dumped into the land. This may cause catastrophic effects on the environment. Therefore, it is very much essential to utilize this fly ash in a novel, eco-friendly and economical way. This innovation targets the problems caused by fly ash due to its non-utilization and provides a sustainable and practical alternative to the existing ceramic material. The developed fly ash ceramic material has unique properties such as it is an ultra-thermal insulating and very lightweight. The density of the developed material is 0.6- 0.8 g/cc so that it can also float on the water.

Its thermal conductivity varies from 0.2-0.5 W/m.k which is four to ten times better compared to the existing ceramic materials. Apart from this, it can be moulded into any size and shape and provides good mechanical strength. The raw material, which is fly ash, abundantly available at zero cost. All these miraculous combinations of desired properties makes it very attractive alternatives to the existing ceramics. Therefore, developed ceramic can be used in the construction & building as roof tile, wall tile, roofing sheets, industrial thermal insulation, decorative pottery items, variety of other applications.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Yogesh D. Urunkar and Chandrakant S. Bhogle Institute of Chemical Technology, Mumbai at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Early Diagnosis of Osteoporosis Using Metacarpal Radiogrammetry and Texture Analysis

Student of National Institute of Technology, Surathkal (NIT), Anu Shaju Areeckal won the award for a Early Diagnosis of Osteoporosis Using Metacarpal Radiogrammetry And Texture Analysis. They carried their project work under the guidance of Prof. Sumam David S.

Osteoporosis is a disease characterized by a reduction in bone mass and micro-structure, causing a high risk to fragility fractures. The gold standard diagnostic technique for osteoporosis, Dual Energy X-ray Absorptiometry (DXA), is expensive and not widely available in India. We developed a low cost prescreening tool for early diagnosis of osteoporosis using hand and wrist radiographs. Automated segmentation method for extraction of third metacarpal bone and distal radius is developed. Cortical radiogrammetry of third metacarpal bone and texture analysis of distal radius is done and the most significant features are used to train classifiers. The pre-screening tool is validated using 138 subjects from the Indian sample population. The segmentation method shows a detection accuracy of 89% and 93.5% for the third metacarpal bone shaft and distal radius, respectively.

The trained artificial neural network (ANN) classifier achieves the best test accuracy of over 90.0%. A linear regression model shows a significant correlation of 0.671 with DXA. A novel low-cost technique to measure cortical bone volume using three dimensional (3D) reconstruction of metacarpal bone is also developed from hand radiographs in three views. Projections of the 3D reconstructed models are compared with manually segmented X-ray images of 20 subjects. The mean error percentage in combined with cortical thickness is 11.2%. The pre-screening tool is a promising technique to identify people with low bone mass and will enable mass screening of people in primary health centres in non- urban areas where DXA is unavailable. This work is done in collaboration with Kasturba Medical College (KMC) Hospital, Mangalore, India and University Hospital of Geneva, Switzerland. The study protocol was approved by the Institutional Ethics Committee, KMC Hospital, Mangalore, Manipal Academy of Higher Education, India.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Anu Shaju Areeckal National Institute of Technology, Surathkal (NIT) at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Formic Acid-Powered Ferrobots For Clean Energy Technology

Students of Indian Institute of Technology, Guwahati, Amit Kumar Singh, Saptak Rarotra and Viswanath Pasumarthi won the award for a Formic Acid-Powered Ferrobots For Clean Energy Technology. They carried their project work under the guidance of Prof. Dipankar Bandyopadhyay and Prof. Tapas Kumar Mandal.

Hydrogen fuel cells work by instigating stored hydrogen to react with oxygen in the air, producing electricity and water. However, generation of pure hydrogen fuel can be a challenging problem. The large-scale production of hydrogen gas is mostly achieved by steam-methane reforming. The major drawback of steam reforming is that – (i) it takes place at high temperature and thus requires external heat energy to maintain elevated temperature and (ii) process results in emission of greenhouse gases as a by-product of the reaction. Furthermore, hydrogen storage and transportation is expensive and requires exclusive tanks to store gas at enormously high pressure. In order to address this issue, we report chemically powered micromotors composed of a collection of iron nanoparticles (FeNPs), namely ferrobots, for rapid on-site generation of pure hydrogen gas using formic acid as fuel.

Instead of storing hydrogen gas in bulky pressurized tanks, motile ferrobots could be easily deployed into aqueous formic acid solutions for on-demand release of pure hydrogen gas, devoid any of greenhouse gases, at room temperature. To demonstrate the proof-of-concept, reactive ferrobots were employed to power a portable toy fan equipped with PEM fuel cell. The pure hydrogen gas required for PEM fuel cell was generated through reaction of a formic acid solution with self-propelling ferrobots, whereas, oxygen gas was produced by catalytic decomposition of peroxide fuel using same ferrobots. The as- generated hydrogen and oxygen gases were directly fed from reaction chambers to the fuel cell electrodes to generate electricity and thus power electronic toy fan. The advantage of this type of micromotor-mediated system is that liquid fuels are used for on-site hydrogen release, and thus gas storage will not be prerequisite in the near future.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Amit Kumar Singh, Saptak Rarotra and Viswanath Pasumarthi Indian Institute of Technology, Guwahati at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Dual action of SPIONS in effective removal of heavy metals and mosquito larvae from water.

Student of Sathyabama Institute of Science and Technology, Chennai, Roshini S. M., Karthika M.and Lavanya Agnes Angalene J. won the award for a Dual action of SPIONS in effective removal of heavy metals and mosquito larvae from water. They carried their project work under the guidance of Dr. Antony V Samrot.

Water is vital for all known forms of life. Due to industrialization and improper effluent disposal, the natural water bodies in many parts of our country are alarmingly contaminated with heavy metals like Cd, Cr, Cu, Ni, As, Pb and Zn which are well known for their toxic impact to environment and human health. In the case of mosquitoes, it is reported that the presence of heavy metals enhances the breeding potency thus supporting the outbreak of various life-threatening diseases like malaria, chikungunya, yellow fever and dengue. Here with the support of Nanotechnology, a commercially available larvicide is used to eradicate the mosquito larvae as well as effectively remove the heavy metals from its breeding platform, water. Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) are employed as the core carrier molecules which are nanoformulated to achieve the dual action.

Chemically synthesized SPIONs are surface modified and tagged with a commercially available larvicide, further encapsulation was performed using a biopolymer. The biopolymer encapsulation of the tagged-SPIONs helped the nanoformulation to accomplish stability and also offer biocompatibility. The biopolymer and SPIONs help in the heavy metal removal and eventually the tagged larvicide exhibit its lethal action against the target, mosquito larvae. Since SPIONs are magnetic nanoparticles, the application of magnetic field eases the removal of both SPIONs incorporated dead larvae and the targeted heavy metal after treatment. This action not only minimizes the release of larvicide in water but also removes the targeted heavy metals and mosquito larvae, thus making the water favourable for use. The ultimate goal of this innovation is to design a unit in association with conventional water treatment filters to bring out the aforementioned dual action and ensure the supply of heavy metal free and larvae free water

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Roshini S. M., Karthika M. and Lavanya Agnes Angalene J. Sathyabama Institute of Science and Technology, Chennai at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Non-catalytic deep desulfurization process using hydrodynamic cavitation

Student of CSIR-National Chemical Laboratory, Pune (CIR-NCL), Nalinee B. Suryawanshi won the award for a non-catalytic deep desulfurization process using hydrodynamic cavitation. They carried their project work under the guidance of Dr Vinay M. Bhandari.

Deep desulphurization of various organics, in general, and transportation fuels, in particular, is a demanding operation, especially from pollution point of view. In this work, a green approach is undertaken for desulfurization of fuels or organics without the use of catalyst or external chemicals/reagents/oxidizing agent using a simple methodology of hydrodynamic cavitation. The process involves pre-programmed mixing of the organic and aqueous phases and can be carried out using simple mechanical cavitating devices such as vortex diode (patented by our group) and orifice. Three organic solvents (n-octane, toluene and n-octanol) containing a known amount of a model sulphur compound (thiophene) up to initial concentrations of 500 ppm were used to verify the proposed method. Very high removal of sulfur content to the extent of 100% was demonstrated. The results were also verified and substantiated using commercial diesel as a solvent. The nature of the organic phase and the ratio of aqueous to organic phase were found to be the most important process parameters.

The developed process has great potential for deep desulfurization of various organics, in general, and for transportation fuels, in particular. The estimated operating cost of  desulfurization using hydrodynamic cavitation is far lower than the present refinery hydrodesulphurization process and adsorptive desulfurization process. The aqueous phase used in the proposed method can be recycled after removing a purge stream (with corresponding make-up water). The process offers many advantages, most importantly ease of operation and mild operating conditions for effective sulphur removal. The proposed method can be effectively implemented for large scale deep desulphurization operations.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Nalinee B. Suryawanshi CSIR-National Chemical Laboratory, Pune (CIR-NCL) at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Utilisation of Real-World Waste Plastic for the Production of Fuel Range Liquid Hydrocarbons using Two-step approach

Student of Indian Institute of Technology, Delhi, Uma Dwivedi won the award for a Utilisation of Real-World Waste Plastic for the Production of Fuel Range Liquid Hydrocarbons using a Two-step approach. They carried their project work under the guidance of Prof. K. K. Pant, Prof. S. K. Naik.

A large amount of waste plastics is being generated because of the accessible properties of the plastics. However, due to lack of efficient end-of-life management in many developing countries; plastics are now posing serious threats to the environment and human health due to its non-biodegradable nature. Liquid fuel formation through thermo-catalytic cracking can provide a good platform for the energy recovery by making use of dumped plastics. The process involves designing an improved two-stage batch reactor system, an effort for the replacement of petro-diesel compounds which covers the synthesis of highly active heterogeneously modified zeolite that supports the catalysts for effective breakdown of waste plastic. The developed two-step approach leads to the 100% conversion of waste plastic into value-added products comprising 60 to 80% liquids, and 20 to 35% gases at a temperature range of 300-350°C.

The results suggest that the carbon chain length was narrowed to C 5 -C 28 when the zeolite catalysts were employed, as well as the significant yield of a controlled fraction of paraffins, olefins and aromatics,  was obtained indicating that the obtained liquids are fuel-like products. The liquid fuel formed is expected to be an effective renewable fuel as supported with the comparable results of GC-MS, 1 H and C 13 NMR, Heating value, Proximate analysis, etc. which can be used as an alternative source of fuel for the IC engine operation. However, the usage of the developed catalyst shows the added advantages of reducing the cracking temperature as well as tailoring the selectivity. Eventually, it should be noted that the negative impacts of waste plastics could be addressed or minimized by recognizing the fact that waste plastics have great potential for resource conservation when converted into a valuable resource.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Uma Dwivedi Indian Institute of Technology, Delhi at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Development of Rapid and Non-destructive Method for Detection of Insect Infestation in Stored Cereal Grains

Student of Indian Institute of Technology, Kharagpur, Gayatri Mishra and Ranjana Rani won the award for research work of Development of Rapid and Non-destructive Method for Detection of Insect Infestation in Stored Cereal Grains. They carried their project work under the guidance of Dr H N Mishra and Shubhangi Srivastava.

India is the second-largest producer of cereal crops in the world but, with the existing facilities, negligible part contributes to post-harvest losses. In this aspect, insect infestation is an alarming concern, accounting for losses in quality as well as quantity. A major portion of the post-harvest losses can be saved by detecting the insects in their early developmental stages and subsequent application of suitable disinfestation approach is undertaken for their control. The current scenario demands rapid methods for insect detection, which can take a lead over conventional methods, on the ground of promptness, usability, non-destructiveness, affordability of start-up cost, and implementation feasibility beyond the laboratory domain. In this study, rapid methods were developed using Fourier transform near-infrared spectroscopy (FTNIR), electronic nose (E-nose), and hyperspectral imaging techniques.

The methods were then statistically compared to select the most suitable technology for the development of a portable sensor assembly for detection of insect infestation of stored cereal grains (i.e. rice, wheat, and maize). E-nose was chosen among the various techniques and the experimental findings were adapted for the development of a low-cost portable sensor. Based on the findings, alcohol and ammonia sensors were integrated with a microcontroller unit to fabricate the sensor assembly, which was effective enough to detect the level of infestation based on the headspace gas composition. The outcome of the project will lead to a convenient, rapid yet nondestructive approach for quality determination of insect-infested cereal grains at various stages during the storage. The sensor will be a boon for developing countries like India to rapidly detect the infestation precisely and support the ideology “saving a grain is producing a grain”.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Gayatri Mishra, Ranjana Rani  Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Image Analyzing Drying Patterns of Blood And Plasma Droplets For The Rapid Detection of Thalassaemia Carriers

Students of Indian Institute of Technology, Kharagpur, Manikuntala Mukhopadhyay and Rudra Ray won the award for a research work of Image Analyzing Drying Patterns of Blood And Plasma Droplets For The Rapid Detection of Thalassaemia Carriers. They carried her project work under the guidance of Prof. Sunando DasGupta and Prof. Maitreyee Bhattacharya.

Thalassaemia is one of the most common single-gene disorder in which the production of haemoglobin is impaired. This autosomal recessive disorder is highly prevalent in Indian populations accounting to ~10% of the world’s thalassaemia carriers. The beta-thalassaemia carrier state resulting from a heterozygous mutation in the beta-globin gene is clinically asymptomatic and thus remain undiagnosed. At present, the gold standard method that is used for carrier detection in hospitals requires expensive instruments, skilled manpower and time, thus, making it difficult to be used as an onsite method. A rapid, portable and automated technology for thalassaemia carrier screening is hence of significant importance. The present study has conclusively proven the distinct patterns observed on the drying of whole blood droplets for carrier and normal samples. Length of the radial cracks is significantly shorter for carrier samples as compared to normal ones. A sample whose average crack length is less than 800 microns can be classified as a carrier sample, whereas the ones with larger radial cracks are considered as normal. Identifying the carrier samples by this image analysis technique gave zero false-negative results.

 

 

 

 

 

 

 

 

 

 

 

These patterns can be further utilized to create a databank for automated classification of carrier samples, by employing appropriate techniques from computational pattern recognition and deep learning. The proposed method will examine the images of dried blood drops, extract its distinctive features and categorize as normal or carrier samples by comparing it with reference images stored in a databank. This automated process will remarkably increase the number of the total population screened for thalassaemia per year in the country and will reduce the burden on the state-run advanced health facilities along with a significant reduction in costs incurred for a screening of each sample.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Manikuntala Mukhopadhyay and Rudra Ray, Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Actin Mimetic ATP Driven Controlled Supramolecular Polymerization

Student of Jawaharlal Nehru Centre for Advanced Scientific Research, Ananya Mishra won the award for a research work of Actin Mimetic ATP Driven Controlled Supramolecular Polymerization. She carried her project work under the guidance of Prof. Subi J. George.

The need of supramolecular systems with increased complexity and structural control is growing in the direction of intriguing functions similar to their biological analogues like DNA and cells. The question, “How far can we push self-assembly?” is recognized as one of the biggest-challenges in supramolecular material science. This work describes a synthetic organic molecule, oligophenylene vinylene functionalized with dipicolyl ethylene diamine (OPVDPA), coming together and stacking on each other in a helical sense on electrostatic interaction with a biological cue, ATP.

This process is very close to events occurring in nature that notably help a cell to maintain its shape, i.e. actin, which undergoes ATP driven temporal polymerization and dynamic instability. The study has come closest in synthetically mimicking this natural process. We have employed the facets of supramolecular chemistry as the area of investigation in this study, which deals with the interplay of non-covalent interactions for self-assembly. Though in synthetic systems it is a fairly new field, most biological processes function are based on these principles. In this context, systems driven by ATP became an inspiration for the team to work further. These systems are uniquely size-controlled over kinetic regimes which allow fascinating stimuli responsiveness and adaptability that could not have been achieved in synthetic systems before. Since the stimulus, in this case, is one of the most ubiquitously present chemicals such as ATP, therefore the study is a benchmark for what can be achieved synthetically. Furthermore as mentioned earlier the prospect of functional accessibility also makes the work more interesting.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Ananya Mishra, Jawaharlal Nehru Centre for Advanced Scientific Research at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Pneumatic Damping Prosthetic Leg For Above-knee Amputees

Students of MES College of Engineering, Kuttipuram, Muhammed Janish and Abhijitnath won the award for a Pneumatic Damping Prosthetic Leg For Above-knee Amputees. They carried her project work under the guidance of Prof. Padmakumar K.

The prime focus of the project is to design cost-effective feedback based on the prosthetic leg for above-knee amputees. Currently, the majority of amputees in India depend on functionally low mechanical legs like Uni-axial knee, ReMotion knee, Jaipur limb, etc. As the cost of a high functional feedback-based leg is around 70000 dollars, therefore, mechanical prosthesis like Uniaxial Knee, ReMotion limb restricts to locks which transfer the load to the ground. The major default of the currently available prosthetics lies in the restricted application, where the patient cannot use it in a bent position when the load is acting normal to the ground, as the lock won’t be working and the patient will stumble.

Also, mechanical legs won’t give any walking assistance as they only provided support & drains more energy. A proportional solenoid valve has been incorporated to control the pneumatic damping system in a mechanical knee. Force sensor at the foot detects the pressure applied by the amputee and adjust the damping resistance at the knee which enables the proposed device to lock the knee joint at any angle and position correspondingly so the amputee can transfer the load to the ground even in a bent position of the leg. Compressed air inside the pistons absorb shock during the stance phase of walking and provide walking assistance during starting of the swing phase of walking and all these applications draw less energy.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Muhammed Janish and Abhijitnath MES College of Engineering, Kuttipuram at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Patient-specific spheroid-on-chip for cancer treatment: combinatory drug screening

Student of Indian Institute of Technology, Hyderabad, Sharanya Sankar and Viraj Mehta won the award for a Patient-specific spheroid-on-chip for cancer treatment: combinatory drug screening. They carried their project work under the guidance of Dr Subha Narayan Rath.

Screening tumor biopsies from cancer patients and finding the appropriate drug combinations to treat the disease at various stages has been a challenge owing to the failure of the in-vitro cancer models to recapitulate the native tissue microenvironment of tumors. The prominence of this work lies in the development of a personalized healthcare set-up for cancer diagnostics and treatment for a patient-specific tumor sample. We have developed a microfluidic platform with strategically placed U-shaped wells for screening the combinatory effect of drugs on tumor spheroids. Also, the optimal flow conditions similar to the in-vivo flow regimes have been simulated. This set-up has inlet ports to provide a continuous flow of media through it to mimic the tumor microenvironment in-vivo. The outlet ports would prevent the back-flow of the excess fluid and maintain the flow conditions inside the wells. The platform allows self-formation of tumor spheroids on passing the cancer cells through the inlet port. Due to the continuous flow of media, the conditions in the well would not be static as compared to the existing models and provide physiologically relevant data with accurate predictive results. Further, the chip can be re-used by sterilizing it through simple techniques making it cost-effective and affordable. Hence, patient-specific tumor samples can be tested in the chip paving a way to create personalized profiling of drugs and their concentration for the treatment. Till date, standard drug treatments are administered to patients suffering from cancer irrespective of their conditions. This system would be a customized set-up to treat individual patients for their specific conditions. This would be a quick and effective approach in treating the fast progressing life-threatening disease. This innovation would be an invaluable step for developing an affordable healthcare set-up for cancer diagnostics and treatment.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Sharanya Sankar and Viraj Mehta Indian Institute of Technology, Hyderabad at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Real Time Surrogate Visual Tracking of Lung Tumours for Effective Radiotherapy

Student of Indian Institute of Technology, Kanpur, Priya Singh, Darshan Ramesh Shet won the award for research work ofReal Time Surrogate Visual Tracking of Lung Tumours for Effective Radiotherapy. They carried their project work under the guidance of Prof. Venkatesh K Subramanian.

A cost-efficient solution to improve the accuracy of radiotherapy given to lung cancer patients. Radiotherapy is a common recourse for treating lung tumors, being considerably more localised than chemotherapy. It, however, faces the challenge of maintaining the focus of the radiation beam on the tumor. Due to physiological factors like respiratory motion, peristaltic motion, cardiac motion, coughing etc, the tumor and its surrounding tissue inside the thorax or abdomen can move dynamically, with a displacement of up to 3 cm. The result of such movement, if ignored during radiotherapy, is the exposure of surrounding healthy tissue and organs, causing severe damage to them.

This research provides a solution by real-time surrogate visual tracking of lung tumours in all the phases during radiotherapy. To achieve a precision simultaneous acquisition of two types of data was done for visual chest surface data and x-ray data of the tumour. To perform visual surface tracking, an array of 4 cameras in conjunction with an adequate number of visible markers were implemented to capture the time evolution of the surface motion. The x-ray tracking of the tumour is performed using a CT scanner. Using the time synchronised x-ray and visual surface tracking data sets, we have built a time and space correlation model of the surface of the chest with the x-ray tracker data using Machine Learning. The patient can be subjected to radiotherapy with beam steering (currently used in hospitals) directed by the surrogate measurements from the correlation model that we have developed. This provides a more accurate, and less expensive method to maintain the radiation focus than the standards used today. Any innovation in the medical field demands extensive trials before adoption. We are seeking the cooperation of SGPGI, Lucknow to provide the infrastructure and subjects for the calibration step.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Priya Singh, Darshan Ramesh Shet, Indian Institute of Technology, Kanpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.