An Automated Panipuri Vending Machine

Students of Tezpur University, Assam, Abhijit Nath, Saurav Jyoti Sarma and Chandeep S. Gogoi won the award for an Automated Panipuri Vending Machine. They carried their project work under the guidance of Er. Polash Pratim Dutta.

The focus of the PVM is to provide hygienic panipuri and to deliver it without consuming much time with a 24/7 service experience to the customers. This machine will work as a single unit, but it will contain various subunits for storing individual items such as hollow bread, different types of ingredients, various types of flavoured water and sauces too. These individual items can be replenished manually when required. The whole process starts with washing and boiling of the potatoes automatically. Then comes the mashing section where all the ingredients and the potatoes will be mashed for making the required paste that will be injected inside the hollow bread. A small heater is attached inside the system to keep the hollow breads fresh and crispy. Since various types of flavoured water will be stored, a refrigerating unit will be there to keep the flavoured water cool and fresh. All the processes will be controlled by a single control unit. This vending machine also has a processing unit which makes panipuri as per customer’s requirements. An interface unit (OLED screen) is there which allows a customer to choose the appropriate option and guided instruction for a transaction. Opening a new stall takes a lot of space but installing this machine will reduce the space requirement. The machine can be moved from one place to others where the electricity is available. It is very easy to install in places like malls, restaurants, luxury hotels, airports etc. This machine is believed to promote acceptability and ensure availability of this Indian Snack across the world.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Abhijit Nath, Saurav Jyoti Sarma and Chandeep S. Gogoi, Tezpur University, Assam, at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Manufacture of Micronutrient Fortified Rice Kernels through Extrusion Technology

Students of Indian Institute of Technology, Kharagpur, Dalbhagat Chandrakant Genu and Jayshree Majumdar won the award for a Manufacture of Micronutrient Fortified Rice Kernels through Extrusion Technology. They carried their project work under the guidance of Dr. H N Mishra.

Iron deficiency anaemia (IDA) has become a serious problem in India. National Family Health Survey (2015-16) revealed that almost half the population is affected (Children- 58.4%, Women – 53 %; Men-22.7 %) with anaemia. Fortification of staple food with essential micronutrients would be a key solution to alleviate the IDA. Being staple food, rice provides a unique opportunity for the micronutrient fortification which leads to address the prevalence of IDA among the affected population. Fortified rice kernels (FRK) have been developed by using rice broken (a byproduct of rice milling industry) and micronutrient premix (containing iron, folic acid and vitamin B12) in three different sizes (long, medium and small) using extrusion technology.

The FRK contains 280-425 mg of iron, 750-1250 µg of folic acid and 7.5 – 12.5 µg of vitamin B 12 per 100 g according to the Food Safety and Standards (Fortification of Foods) Regulation, 2016. Optimization of the extrusion process parameters such as die head temperature, barrel temperature, screw speed, feeder screw speed and feed moisture content were done to produce FRKs which resemble the natural rice in physical, nutritional, sensory & cooking characteristics. Drying process was standardized to avoid any fissure formation in the FRKs. The FRK, thus produced, is mixed with the natural rice in the ratio of 1:100 to obtain iron-fortified rice (IFR). Sensory study of rice dishes prepared using FRK (made by using Sona masuri Cv. rice) had shown a good resemblance with those of the natural rice dishes both in raw and cooked form. The iron losses during washing (1%), soaking (2%), cooking were negligible (8%). A pilot-scale facility of production capacity 100 kg FRK per day has been established at IIT Kharagpur, promoting the concept of “Make in India”.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Dalbhagat Chandrakant Genu and Jayshree Majumdar, Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Development of Process Technology for Manufacture of RTD Carbonated Grain Beverage

Students of Indian Institute of Technology, Kharagpur, Anjali Thakur and Pooja Pandey won the award for a Development of Process Technology for Manufacture of RTD Carbonated Grain Beverage. They carried their project work under the guidance of Dr. H N Mishra.

There is a huge demand for carbonated soft drinks amongst the consumers. Most of the available soft drinks typically contain artificial sweeteners, colors and harmful additives which lead to set of diseases like diabetes, obesity, teeth & bone damage, decrease in metabolism etc. Therefore, a cereal-based carbonated beverage mixed with adequate protein and energy can serve as a healthy alternative. Maize and Bengal gram were roasted at a temperature of 160-180C while finger millet at 80- 120C for 10-30 min. The optimized conditions for roasting of the maize, Bengal gram and ragi were 180C for 10 min, 180C for 27 min and 110C for 30 min; respectively were determined using face centred composite design (FCCD) and response surface methodology (RSM).

The formulation of the beverage premix was obtained using linear programming in the combination of 30g, 30g, 10g, 20g and 10g of roasted maize, Bengal gram, finger millet flours, sugar (powdered) and pea protein isolate, respectively. The formulated instant carbonated cereal beverage was high in protein and energy at low cost (Rs 10/100 g). The prepared carbonated grain-based drink was very much nutritious (16% protein and 390 Cal/ 100g energy). The final formulation obtained gave an adequate amount of iron (11.6 mg/100 g). The effect of carbonation was found best for 8% carbonation powder concentration with 1:4 beverage mix to water ratio. The sensory evaluation showed overall acceptability of 7.7. Unique features are as follows-

  • The formulated instant carbonated cereal beverage with high protein, energy and low cost in the form of dry powder is one of the unique features of the present beverage mix.
  • The prepared carbonated grain-based drink is very much nutritious (16% protein) and easily digestible. 
  • The final formulation obtained gave an adequate amount of iron (11.6 mg/100 g). 
  • The sensory evaluation showed overall acceptability of 7.7. 
  • The effect of carbonation was found best for 8% carbonation powder concentration with 1:4 beverage mix to water ratio. 
  • Dry beverage powder can be easily stored in sachets or sealed containers with maximum flexibility of transportation.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Anjali Thakur and Pooja Pandey, Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Audience response device for Deaf and mute classroom

Student of Indira Gandhi Delhi Technical University for Women(IGDTUW), Manasi Mishra won the award for a Audience response device for Deaf and mute classroom. They carried their project work under the guidance of Prof. S. RN Reddy.

Speaking and hearing plays an important role in effective teaching, individuals who lack these abilities faces an uphill battle. Quantum of work has focused on designing various approaches to teach deaf and mute students. However, it is equally important to assess whether students are following the course materials or there is a need to adjust the pace and methodology of teaching. Creating an active learning environment in D & M classroom is a tedious task as it becomes very difficult for a teacher to observe every student’s response at a time through sign language. The level of their enthusiasm and active engagements in the classroom can degrade due to being unheard or unnoticed. This scenario demotivates them to respond in classroom. This innovation can facilitate multiple classroom activities easily without the need for speaking or hearing such as performing quiz, aggregating & analyzing student’s responses, taking attendance, receiving student’s feedback & handling queries, assessment of every individual, Assistance for emergency or panic situation.

Real-time feedback will allow the lecturer to adapt the lecture during the presentation so as to achieve the maximum efficiency during the lecture & also to modify the future lectures based on the “lessons learned” from the past cases. Students whose performance is poor needs special attention; their performance can be shared automatically to their guardians via E-mail. In future it can also be integrated with the learning management system designed specially for deaf & mute students. This system is low cost, easy to use & configure, uses the light weight protocol for device to device communication, allows remote monitoring through the use of cloud computing technology, highly scalable, can be easily integrated with existing infrastructure.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Manasi Mishra, Indira Gandhi Delhi Technical University for Women(IGDTUW) at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Multifunctional Granulator (MFG) -A Multi functional device to prepare dried spherical granules

Student of Andhra University College of Pharmaceutical Sciences, Visakhapatnam, Rajendra Prasad Moturu won the award for a Multifunctional Granulator (MFG) -A Multifunctional device to prepare dried spherical granules. They carried their project work under the guidance of Prof. K.V. Ramana Murthy.

From the past drug discovery had made the new exploration in the field of R&D and Production. Even though most of the drugs are discovered, the way of presenting these drugs to the patients has not changed since the tablet dosage form is playing a key role in patient health care management, due to its patient compliance. The manufacturing process of the tablets dosage form is having more number of process steps like mixing, wet massing, granulation, drying, size separation, punching and it is a very tedious process depending upon preparation technique. The present new innovation “Multi-Functional- Granulator” can make a new trend in the production of granulation industries, as it is designed to be single equipment for all these steps. Multi-Functional- Granulator is well-designed equipment involving mixing, wet massing, granulation, drying and size separation of dried spherical granules.

By using this equipment we can see a 3-Dimensional mixing which is required for uniform mixing and wet massing. Granulation technique is also well designed as it is having a double granulation to form spherical granulation of selective size requirement. The next subsequent step in the process is to dry the spherical granules, this is achieved through more surface area in less space by passing hot air through spirally arranged trays. These granules are collected according to their sizes by using a size separation technique-“Sieve Analysis”. All these process steps described are performed within a single equipment therefore it reduces the cost, time, set up area/space, human intervention and it is one of the best equipment in the point of design and efficiency for granulation industries like Pharmaceuticals, API; Chemicals, Ayurvedic, New Chemical Entities (R&D), Fertilizers and Detergents.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Rajendra Prasad Moturu, Andhra University College Of Pharmaceutical Sciences, Visakhapatnam at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

A Simple, Non-invasive, Low Cost, Point of Care, Colorimetric Method, using Reactive Oxygen Species induced Lipid Peroxidative changes in Saliva, to Assess the Risk of Oral Pre-cancerous Lesions and Oral Squamous Cell Carcinoma in Chronic Smokers

Student of Greenwood High International School, Bengaluru, Nikhiya Shamsher won the award for research work of A Simple, Non-invasive, Low Cost, Point of Care, Colorimetric Method, using Reactive Oxygen Species induced Lipid Peroxidative changes in Saliva, to Assess the Risk of Oral Pre-cancerous Lesions and Oral Squamous Cell Carcinoma in Chronic Smokers. They carried their project work under the guidance of Aloysius D’Mello.

Smoking, the leading cause of oral cancer in India, kills over 5 people every hour. As high mortality is due to late diagnosis, early detection is vital. Free radical-induced lipid peroxidation (LP) is known to promote multistep oral carcinogenesis. Free radicals generated by smoking, damage polyunsaturated fatty acids releasing end-product Malondialdehyde (MDA). A simple, home-based test was devised to determine salivary Malondialdehyde to assess the early risk of oral pre-cancer and cancer. It was hypothesized that heavier smokers would exhibit a greater degree of salivary LP.

A highly sensitive QuitPuff reagent was formulated which when heated with saliva, produces a colour change, directly proportional to the amount of MDA. The MDA level was measured by matching the color change with a colorimetric Lipid Peroxidation Index (LPI) chart. QuitPuff was tested on 500 subjects and validated using UV Spectroscopy, the gold standard for the test. The mean LPI was consistently and significantly elevated (P & lt; 0.001) in smokers with oral pre-cancer and cancer (4.34), smokers who smoked more than 20 (4.12), between 10-20 (3.43) and less than 10 cigarettes per day (2.43) as compared to non-smokers (0.26). The mean LPI’s of the test and validation methods correlated. Spearman’s correlation indicated a significant positive association between colour changes and UV spectroscopy readings (r=0.93). QuitPuff detected the salivary MDA levels with 96% accuracy. Smokers exhibited a greater degree of salivary LP as compared to non-smokers, the heavier the smoker, greater was the degree of LP. QuitPuff has great potential as a point-of-care test for oral pre-cancer and cancer.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Nikhiya Shamsher, Greenwood High International School, Bengaluru at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Understanding Sequence-Disorder-Function Relationship of an Intrinsically Disordered Protein to Design Soil Salinity Sensor

Student of Indian Institute of Technology, Madras, Sneha Munshi won the award for research work of Understanding Sequence-Disorder-Function Relationship of an Intrinsically Disordered Protein to Design Soil Salinity Sensor. They carried their project work under the guidance of Dr Athi Narayanan N.

Soil is one of the important elements of our ecosystems which has been subjected to degradation due to both natural and man-made causes. Native rock weathering, low precipitation, high surface evaporation, wind, irrigation with saline water or disposal of solid waste severely affect the salinity of the soil. The statistical analysis revealed loss of 12 billion dollars of the agricultural crop every year and 3,230,000 km2 irrigated land has been affected globally. To handle these issues on time, soil salinity needs to be monitored routinely. Advancements have been made in recent years to explore intrinsically disordered proteins (IDPs) as biosensors. These are an essential part of proteome and do not possess any well-defined structure but still are functional.

These proteins are highly sensitive to temperature and solvent fluctuations. In current work, we have revealed the effect of increasing salt on the structure and stability of Cyt R DNA Binding Domain (DBD). We observed that Cyt R gradually attains secondary and tertiary structure with increasing salt concentration. Cyt R displays a graded increase in structure, stability and folding rate on increasing the osmolarity of the solution that mimics the non-specific screening by DNA phosphates. The gradual structural acquisition is observed for almost all basic salts like phosphate, sodium chloride, potassium chloride and sodium sulfate. This property of Cyt R can be exploited to be used as soil salinity sensor.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Sneha Munshi, Indian Institute of Technology, Madras at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Anemia meter

Student of Amrita Vishwa Vidyapeetham, Coimbatore, Jeethu Raveendran won the award for research work of Anemia meter. They carried their project work under the guidance of Dr T. G. Satheesh Babu.

Anaemia is a disorder that affects over one billion people worldwide. Typically, anaemia is detected by examining the haemoglobin/haematocrit values. Generally, these tests were conducted using a haematology analyzer, haematocrit centrifuge or spectrophotometer. These instruments are expensive, non-portable, and require operation by trained personnel; they are therefore unavailable in many low-resource settings. These tests are also expensive and are not affordable by the common man. This indicates a requirement of accessible and affordable technology for anaemia detection. A simple battery-powered microhaematocrit centrifuge system with commonly available materials like DC motor, polyethylene terephthalate (PET) sheet, mounting hub, and screws was fabricated.

The development of the system is as simple as it can be assembled by any nontechnical personnel and can be used as an electric toy. This portable system could be used as a replacement for commercial benchtop centrifuge which is bulky and expensive. The device can be used as a simple anaemia reader. The system also has been employed for the estimation of haematocrit and using the haematocrit values the haemoglobin levels were calculated. The main advantages of the device are its simplicity and low cost which make this a global solution for haematocrit estimation, anaemia detection and serum-based diagnostics in resource free settings.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Jeethu Raveendran, Amrita Vishwa Vidyapeetham, Coimbatore at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Economical Paper-Strip For Early Stage Mastitis Disease Detection In Cow

Students of Sri Venkateswara Veterinary University, Tirupati (SVVU), Harika Chappa, Avisek Barla, Navin V Narayanan, Sudip Chakraborthy and Ahila Yegappan won the award for research work of Economical Paper-Strip For Early Stage Mastitis Disease Detection In Cow. They carried their project work under the guidance of Prof Y. Hari Babu.

Mastitis is an inflammation of the mammary gland in animal’s udder that adversely affects the animal health, therefore, leading to an annual economic loss of around $35 billion worldwide and 7615.15 crores rupees in India. Currently, the disease is detected in clinical settings by expensive techniques and also in places, which are miles away from remote villages.
The microfluidic paper-based analytical device fabricated for mastitis disease diagnosis in cattle is highly economical i.e. as low as Rs. 1/-, portable, ecologically compatible and self-diagnostic. It will help farmers to screen and monitor the most economically devastating mastitis disease in the bovine species at an early stage. The detection time of disease using the proposed method is 15 minutes approximately with high accuracy and efficiency. The major indicators of mastitis disease are the somatic cells, whose deformities are envisioned based on the qualitative and quantitative detection done on a paper-strip method.

The unique combination of the reagent and dye achieve a cost-effective solution. A drop of milk is to be added to the reagent incorporated paper strip having desirable pore size with hydrophobic nature, and incubated for about 10 minutes. Through the natural capillary action, the milk reacts with the reagent and provided dye is to be added. It will show an instant change in colour. Colour intensity is the measure of the prevalence of mastitis disease, captured by mobile camera and quantified by software or is self-descriptive through the naked eye. This paper- strip can be used by farmers, dairy industries, veterinarians, the households and regulatory agencies as an indicator of the safety and suitability of raw milk for consumption by humans and also preventing zoonotic diseases. Farmers can negotiate a good price with the dairy industry based on milk quality information from paper-strip and enhance the quality of life. Affordable Paper-strip can be utilised by relatively untrained people and it ensures laymen terms to deliver the best information and is complete with easy-to-understand information and enhance dairy industry contribution to Indian GDP.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Harika Chappa, Avisek Barla, Navin V Narayanan, Sudip Chakraborthy and Ahila Yegappan, Sri Venkateswara Veterinary University, Tirupati (SVVU), at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Fighting resistance in cancer cells due to bacterial infections with modular drug platforms: An idea towards personalized medicine

Student of Indian Institute of Technology, Delhi, Rohini Singh won the award for research work of Fighting resistance in cancer cells due to bacterial infections with modular drug platforms: An idea towards personalized medicine. They carried their project work under the guidance of Prof. Shalini Gupta.

The motive of the study is to target intracellular bacterial infection in cancer and analyse the impact of bacterial presence on the efficacy of chemotherapeutic drug. We observed that bacteria have the capability to biotransform the anticancer drug which might affect its activity and it is the reason for resistance in cancer cells. We have developed multifunctional liposomes with dual capability to simultaneously target cancer and cancer cell internalized bacterial cells. The liposomes are encapsulated with doxorubicin and surface is functionalized with an antibacterial peptide sushi S3 which is used as drug delivery vehicle as a proof-of-concept in an in vitro model. A realistic in vitro cell model was created in which Huh-7 liver cancer cells were infected with Salmonella typhi. It has been observed that S. typhi has the potential to cause gall bladder and liver cancers.

The efficacy of the drug delivery platforms has been tested on S. Typhi- infected liver cancer (Huh-7) cell models. The presence of S. Typhi definitely decreased the efficacy of dox against Huh-7 cancer cells. The overall efficiency to kill cancer and bacteria got improved by approx. 70% than free anticancer drug/anticancer alone when both compounds were given in the liposomal form. The efficacy of the nano-formulations can be enhanced by conjugating specific ligands expressed on cancer cells such as folic acid. We envision that such combinatorial platforms would definitely give a new direction in targeting co-existing infections with synergistic effects and help in curbing the drug resistance problem.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Rohini Singh, Indian Institute of Technology, Delhi at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

A more accurate detection and intrinsic subtype classification of breast cancer using machine learning.

Student of Indian Institute of Technology, Kharagpur, Bikash Ranjan Samal won the award for research work of A more accurate detection and intrinsic subtype classification of breast cancer using machine learning.. They carried their project work under the guidance of Dr. Ranjit Prasad Bahadur.

Breast cancer is a heterogeneous and complex disease, with a high mortality rate. It is one of the predominant cancer types that affect millions of cases and cause thousands of deaths every year in India. The effective treatment and prognosis of breast cancer development relies largely on a correct classification and also help patients in avoiding improper chemotherapy and undergo its side effects. In our studies, we developed a classifier to distinguish the five intrinsic subtypes of breast cancer using microarray gene expression profile data. The model is based on supervised learning using a support vector machine algorithm for classification.

The genes required for acting as the important features for classification were identified with a greedy algorithm i.e. recursive feature elimination method via logistic regression. We identified a panel of 40 genes which serve as the important features for classifying the breast cancer intrinsic subtypes, using their gene expression profile data. The modelled classifier has an accuracy score of 93-96% and it is more than the previous method. It has good precision, recall and F score for prediction. This method uses a minimal number of genes as features, which indicates that lesser the number of features, lesser will be the number of gene probes that can be used in diagnostic chips to detect breast cancer and its subtype. In the identified panel of genes, it is found that some of them are involved directly in the cancer process which may act as prognostic signatures.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Bikash Ranjan Samal, Indian Institute of Technology, Kharagpur at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Proteasome Activation: A potential drug target for treatment of Parkinson’s Disease.

Students of Indian Institutes of Technology, Madras, Mohd Ahsan and P Chinmai won the award for research work of Proteasome Activation: A potential drug target for the treatment of Parkinson’s Disease. They carried their project work under the guidance of Prof. Sanjib Senapati.

Parkinson’s disease (PD), an age-dependent neurodegenerative disorder occupies a significant portion of the total disease burden of non-communicable diseases in our country. The accumulation of inclusion bodies/aggregation-prone proteins along with the loss of proteostasis eventually leads to death of neurons. Proteasome complex is known to be one of the key regulator of proteostasis in all the cells where the damaged and misfolded proteins are degraded. Recent studies have reported decreased proteasome function as a primary cause for many neurological diseases including PD. There are FDA approved inhibitors of proteasomal activity, however, development of proteasome activators is rarely looked at. One of the prime reason behind this is the complexity of human proteasome, limited understanding of the mechanism of activation. Hence, in our study, we exploited the archaeal proteasome complex through virtual screening and state-of-art molecular simulation techniques to decipher the mechanism of proteasomal activation by the HbYX motif (present in endogenous activators).

Results from our study showed that the extreme C-terminal residues (Tyr & Arg) of this motif directly participate in opening the central pore of the archaeal 20S complex. Arginine being the charged residue contributes more to the binding energy and tyrosine residue interacts with the N-terminal loop of each α subunit through a H-bond with the backbone of Gly19 (α subunit) side chain of Arg20 (α subunit). Thus, the dipeptide- Tyr-Arg is exploited as the initial lead for database screening followed by rigorous docking analysis. This extensive library screening resulted in three activator small molecules, working in both archaeal and human 20S complex. From our study we have successfully characterized the first lead chemical moieties as the potential proteasome activators. Hence, our results showed that the structurally simple archaeal 20S complex can serve as the ideal target for structure based drug-designing in order to find activators for the human 20S complex.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Mohd Ahsan and P Chinmai, Indian Institutes of Technology, Madras at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Production of effective and low cost dapsone-phytochemical hybrid candidate for use in multidrug therapy against Mycobacterium leprae

Student of Institute of Medical Sciences and Sum Hospital (IMS and Sum Hospital) Bhubaneswar, Shasank Sekhar Swain won the award for research work of Production of effective and low cost dapsone-phytochemical hybrid candidate for use in multidrug therapy against Mycobacterium leprae. They carried their project work under the guidance of Prof. Rabindra Nath Padhy, Prof. P. Sudhir Kumar.

Leprosy, the staggering infectious disease caused by the obligate intracellular Mycobacterium leprae continues to be the belligerent public health hazard for causation of high disability and eventual long-term morbidity, even treatment with ongoing multidrug therapy (MDT). From the vast ethnomedicinal records and ethnopharmacological investigations, phytochemicals are potent against infectious diseases; but, none of those has gone up to the pure-drug stage due to the lack of the desired drug-likeness values and the required pharmacokinetic properties. To overcome the drug-resistant problem, the improvement of the primary antileprosy sulfa drug, dapsone through chemical conjugation with a suitable phytochemical for reuse of dapsone in empiric antibacterial therapy is the primary goal. With various bioinformatics and chemoinformatics analysis, dapsone-phytochemical conjugates were synthesized adopting azo-dye coupling reaction, and structural interpretation was carried out by UV, FTIR, NMR, HPLC, LCMS, and SEM.

From the in vivo ‘mice-foot-pad-propagation’ study, the ‘dapsone-thymol’ hybrid product at the WHO recommended dose for dapsone, 0.01 % mg/kg reduced one-log bacilli-population in ‘dapsone-resistant’, and no bacilli were found in ‘dapsone-sensitive’ M. leprae infected mice foot-pad in three months of oral treatment. Additionally, from the in vitro host-toxicity study with cultured-human lymphocytes, it was confirmed that the dapsone-thymol conjugate was safe for oral administration up to 5,000 mg/L, since a minor number of dead cells were found under a fluorescent microscope. In conclusion, the newly synthesized ‘dapsone-thymol hybrid’ product could be used in a revised MDT in place of dapsone against M. leprae after successful validation in the clinical phase. Indeed, conjugation of a phytochemical with the obsolete drug could serve the new trend in current antibacterial drug development with resources and time saving through the ingenious combination of bioinformatics and medicinal chemistry tools.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Shasank Sekhar Swain, Institute of Medical Sciences and Sum Hospital (IMS and Sum Hospital) Bhubaneswar at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Design and development of interlock mechanism based bio-compatible, user-friendly and cost-effective elbow disarticulation prosthesis

Students of Indian Institute of Technology, Guwahati, Mrutyunjay Maharana and Bhabani Shankar Nayak won the award for research work of Anti-Pesticide Dermal Gel. They carried their project work under the guidance of Dr Sisir Kumar Nayak.

 

 

 

 

 

 

 

 

 

The upper limb amputation is a serious problem for human as it causes hindrance to various daily activities. Especially for the elbow amputation, it causes severe damage to the movement of the hand for a different common purpose. The available prosthetic elbow and disarticulation prosthesis are very costly and cannot be afforded by the common and economical backward people in India. By realizing the extreme requirement of elbow amputee people’s usability and affordability, the design and development are carried out for interlock mechanism-based bio-compatible, user-friendly and cost-effective elbow disarticulation prosthesis. There is no complicated electronics and motorized actuation involved therefore it makes this design simple. This design incorporates the internal slot mechanism which will provide an adequate motion of the artificial hand connected to the elbow joint. The joint is developed mechanically which helps the prosthesis to bring back sound gait of elbow and hand similar to the normal elbow. The design is very compact and not exposed outside of the hand so that normal clothing for the patient is not hampered. The design of an elbow joint incorporates a simple machining and manufacturing process for easy fabricated. Most importantly, the cost of the prosthetic joint is around Rs.1500-2000/unit by machining of a single unit. However, the cost can be further reduced by mass production. Since the innovation is focused on the mechanical linkage based low-cost prosthesis, this innovation will certainly benefit the elbow amputee people to bring back their normal hand gait cycle. Commercialization of this innovation is going to serve the majority of the elbow amputees. As the development is specified for a very unique group of specially-abled people, the implementation of this will have a positive impact on society.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Mrutyunjay Maharana and Bhabani Shankar Nayak, Indian Institute of Technology, Guwahati at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Development of improved biocatalysts for D-allulose production utilizing the low-cost agro-industrial residues

Student of Center Of Innovative and Applied Bioprocessing(CIAB) Punjab, Satya Narayan Patel won the award for research work of Development of improved biocatalysts for D-allulose production utilizing the low-cost agro-industrial residues. They carried their project work under the guidance of Dr Sudhir P. Singh.

D-allulose (D-psicose) is a C3 epimer of D-fructose. It is a rare sugar having 70% of the relative sweetness of table sugar. It exerts only 0.3% calories of table sugar. Consumption of this sugar is beneficial to human health in several ways i.e. anti-obesity, anti-diabetic, anti-oxidative, hypoglycemic, anti-dyslipidemic, and neuro-protective effects. It improves the texture of food materials with pleasant flavour through the Maillard reaction. The team has developed a novel enzyme- systems for the biosynthesis of D-allulose from D-fructose. A fusion of yeast Smt3 at the N-terminus of Agrobacterium tumefaciens D-allulose 3-epimerase improved thermal tolerance of this enzyme by several folds. This modified chimeric protein was covalently attached to the magnetic nanoparticles. This nanoparticle-enzyme conjugation system was demonstrated to be more thermo-stable and recyclable. Recently, we have discovered a novel gene encoding D-allulose 3- epimerase enzyme from the metagenomic information of a thermal aquatic habitat of extreme temperature. The protein sequence of this novel enzyme exhibits significant dissimilarity with any known protein in the public databases. This novel biocatalyst shows excessive thermal stability at 50-60 °C temperature, which is considerably higher than any D-allulose 3-epimerase enzyme known till date. These bio-catalytic systems have been used to bioprocess several agro-industrial wastes (e.g. fruit pomace, cabbage waste, banana pseudostem, and cane molasses) for the transformation of in-situ D-fructose into D-allulose.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Satya Narayan Patel, Center Of Innovative and Applied Bioprocessing(CIAB) Punjab at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

Towards Application of Helical Nanorobots for Biomedical Applications.

Students of Indian Institute of Science, Bangalore, Malay Pal, Debayan Dasgupta, Arijit Ghosh and Neha Somalwar won the award for a research work of Towards Application of Helical Nanorobots for Biomedical Applications. They carried her project work under the guidance of Prof. Ambarish Ghosh, Dr Deepak K Saini, Prof. Ramray Bhat.

Magnetically driven nanorobots have gained immense interest for biomedical applications because of its wide range of potential applications. The team is working on helical shaped magnetic nanorobots that can be internalised by the cells when incubated for around 24 hours. Subsequently, these internalised nanorobots can be actuated remotely inside the living cell by application of a rotating magnetic field. This novel technique of intracellular manipulation is completely benign to the living cells which has been confirmed from cell viability studies. Our work also confirms that these tiny nanorobots can promptly detect changes in local environment inside a living cell which is very promising for new studies in cell biology and new techniques for sensing of an intracellular matrix. Another important application of helical magnetic nanorobot is that it can sense viscosity of the surrounding environment with high Spatio-temporal resolution as it moves through the medium. This active measurement is much faster than conventional passive rheological technique. Along with its ability to be positioned in any arbitrary location within the fluid medium, it is now possible to find out local heterogeneities in the medium very easily. Any other parameter that causes a change in viscosity of the medium, for example, temperature, can also be measured using this active system. The current method can be applied to both Newtonian and Shear-thinning fluids which is an added advantage as most of the biological fluids are also shear thinning. Above two results suggest that helical magnetic nanorobot is an appropriate candidate for future biomedical applications. We are exploring further for other exciting features of the helical magnetic nanorobots. Hopefully, in a few years, we shall witness a paradigm shift in the biomedical industry with the help of these nanorobots.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Malay Pal, Debayan Dasgupta, Arijit Ghosh and Neha Somalwar, Indian Institute of Science, Bangalore at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.