Affordable and Rapid Paper-based Test Kits for Antimicrobial Susceptibility Assays

Students of the Indian Institute of Technology, Kharagpur were received the BIRAC-SRISTI Gandhian Young Technological Innovation Award-2017 for developing an Affordable and Rapid Paper-based Test Kits for Antimicrobial Susceptibility Assays.

Shantimoy Kar including team members Tarun Agarwal, Shubhanath Behera, Varun Varma developed this test kit under guidence of Dr. Suman Chakraborty and Prof. Tapas K. Maiti. At the present scenario, increasing drug resistance of the pathogenic microbes is a global threat to the human mortality. To meet this challenge, there is a need to develop a rapid antimicrobial susceptibility testing platform. The cur rent methodologies for detec ting antimicrobial susceptibility suffer from severe limitations, thereby negatively effecting patient's survival rates. These techniques are time consuming, labor intensive, require sophisticated infrastructures and skilled personnel; which collectively increase overall cost of the diagnosis. In this context, herein, a simple paper based microfluidics platform for easy and rapid execution of antimicrobial susceptibility assays is developed.

Device schematicsThe device consists of a paper-based platform which includes four different layers: a base layer, a bacterial suspension layer, a drug layer and a top layer containing a chromogenic substrate which changes color in accordance to the bacterial metabolic activities. The developed technology provides faster detection (~ 5-6 h) and multiplexing (upto 8 different samples could be analyzed) in comparison to the gold-standard stereotype laboratory practices. Moreover, portable nature and ease of fabrication method collectively make it more convenient for functioning at resource limited settings.

For this innovation Prof. Anil K Gupta Co-ordinator, SRISTI and Founder, Honey Bee Network, honored Shantimoy Kar and team Tarun Agarwal, Shubhanath Behera, Varun Varma, Department of Applied Technology, Indian Institute of Technology, Kharagpur, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

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