Growth factor free strategy for therapeutic neo-vascularization

Student of Indian Institute of Technology, Madras Shivam Chandel and Abel Arul Nathan S won the award for a Growth factor free strategy for therapeutic neo-vascularization. They carried her project work under the guidance of Dr. Madhulika Dixit.

Endothelial progenitor cells (EPCs), a subset of circulating mononuclear cells are currently being studied as candidate cell sources for revascularization strategies. Increasing the number and/or improving the function of EPCs may be promising in the treatment of atherosclerotic disease, ischemia or Heart Failure. Current therapies for neo-vascularization are based on the administration of growth factors and nitric oxide donors. Administration of NO-donors has been promising but failed to promote neo-vascularization particularly in elderly and diabetic patients. Several clinical studies using growth factors have failed in phase II which successfully passed phase I, either due to their short half-lives or due to their harmful side effects. Studies have shown that application of fluid shear stress induces the differentiation of mononuclear cells to endothelial cells. Shear stress also enhances capillary blood flow and modulates the function and expression profile of angiogenic genes. However, the effect of shear stress on the circulating mononuclear cells is not well characterized. Hence, to study the effect of shear stress on the angiogenic potential of circulating mononuclear cells, a cone plate-based instrument assembly has been developed. This study focuses to enhance the angiogenic potential of mononuclear cells through ex-vivo preconditioning via application of shear stress.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Shivam Chandel and Abel Arul Nathan S, Indian Institute of Technology, Madras at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

 

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