Low-cost, easy-to-use, in-house developed electric cell impedance sensing (ECIS) system for studying the dynamic behaviour of the biological cell

Student of Indian Institute of Technology (Banaras Hindu University), Varanasi, Uvanesh Kasiviswanathan won the award for research work of Low-cost, easy-to-use, in-house developed electric cell impedance sensing (ECIS) system for studying the dynamic behaviour of the biological cell. He carried their project work under the guidance of Prof. Neeraj Sharma, Dr Sanjeev Kumar Mahto.

Physiological properties of each and every living organism (either diseased or normal) changes randomly with the external environmental conditions. Thus, the continuous monitoring of these properties is crucial for both long and short term analysis of any particular in vivo models. Generally, a large number of animals are used as in vivo models to analyse and predict the effect of various synthesized/formulated moieties and moreover they are being sacrificed as and when required during the drug screening process. In addition, in the pre-clinical and clinical trials/stages such step leads to a huge failure rate not only due to differences in the in vitro and in vivo models selected but also because of the incompatibility issues concerning to the sensing devices utilized for both the models.

Thus, an improved measuring/screening platform that can interface with both the in vitro and in vivo models need to be developed for measuring the dynamic behaviour of any biological cell/system. This study has designed and fabricated a low-cost, easy-to-use, portable electric cell impedance sensing (ECIS) system that shows great potential for analysing the physiological parameters in real-time both for in vitro and in vivo models. It is important to note that our device, by any means neither affects nor influences the biological models being tested. Further, the experimental data can be correlated with the physiological parameters through a theoretical calculation of the lumped-elemental electrical parameters of cell-electrolyte interface and metal-electrolyte interface.

The Hon’ble Vice President of India, Shri M. Venkaiah Naidu awarded the Gandhian Young Technological Innovation (GYTI) Award to Uvanesh Kasiviswanathan, Indian Institute of Technology (Banaras Hindu University), Varanasi at the GYTI 2019 Awards function held at Vigyan Bhawan, New Delhi on July 06, 2019.

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